Thiobarbituric Acid Reactive Substances

Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.

Also Known As:

Networked: 1293 relevant articles (54 outcomes, 130 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Steinberg, Jean Guillaume: 9 articles (01/2010 - 06/2002)
2.	Jammes, Yves: 9 articles (01/2010 - 06/2002)
3.	Wyse, Angela T S: 8 articles (12/2015 - 06/2003)
4.	Naito, Yuji: 8 articles (01/2014 - 04/2004)
5.	Yoshikawa, Toshikazu: 8 articles (01/2014 - 04/2004)
6.	Dal-Pizzol, Felipe: 8 articles (11/2013 - 08/2007)
7.	Manoharan, S: 8 articles (04/2006 - 12/2002)
8.	Rocha, João B T: 7 articles (04/2015 - 02/2002)
9.	Singh, Nirmal: 7 articles (09/2014 - 06/2011)
10.	Takagi, Tomohisa: 7 articles (01/2014 - 04/2004)

Related Diseases

1.	Body Weight (Weight, Body) 05/01/2015 - "Furthermore, the body weight gain and plasma TBARS concentration in mice fed a diet with the addition of catechins depends on the degree of epimerization of catechins and decreases with increasing content of catechins belonging to the (-) form (2S, 3R). " 07/01/2013 - "Body weights, anti-oxidant profile (GSH, GST, TBARS and protein carbonyls) in testis, testis weight, testicular LDH, sperm count and histopathology were conducted. " 06/01/2013 - "Animals exposed to contaminated soil presented a few significant alterations by comparison with control animals: TBARS and protein carbonyl levels increased, the relative weight of the kidneys increased, metabolic parameters (body weight gain, food intake, water consumption, urine and feces production) depressed and there was behavioral alteration. " 05/01/2013 - "Peak VO2 and anaerobic threshold normalized to body weight were significantly lower in MetS patients by 25 and 31%, respectively, and inversely correlated with serum TBARS (r = -0.49 and r = -0.50, respectively). " 07/01/2011 - "There was a significant increase in body weight (P < 0.05), BMI (P < 0.05), levels of TBARS (P < 0.0001), LH (P < 0.005) and carbonyls (P < 0.0001) and a significant decrease of levels of AC (P < 0.005) and GSH (P < 0.0001). "
2.	Hemolysis 01/01/2014 - "In two-year-old rats, preventive administration of the neiroglutam caused a significant reduction in the TBARS plasma concentration (34.5%, p < 0.05), increased SOD activity, and increased the time of acid-induced hemolysis of erythrocytes (40%, p < 0.05)." 07/15/2006 - "The impairment of redox status was indicated by increases in plasma thiobarbituric acid reactive substances and oxysterols and an increased blood susceptibility to in vitro free-radical-induced hemolysis. " 01/01/2005 - "Vit E treatment decreased elevated TBARS levels in plasma and RBC and also increased reduced RBC vit E levels, and prevented RBC membrane destruction and hemolysis. " 01/01/2005 - "A significant increase in %delta for COHbc in the <1.5 kg birthweight subgroup compared with those > or =1.5 kg, possibly indicative of hemolysis, was not matched by similar changes in %delta for TBARS or protein carbonyls, and may therefore not be a result of photo-oxidation. " 12/01/1997 - "Protein fragmentation takes place prior to significant hemolysis or lipid peroxidation, as evaluated by thiobarbituric acid-reactive substances measurements."
3.	Colitis 08/21/2014 - "Although the monotherapies were also effective in improvement of colitis markers, the combination therapy was much better in improvement of colon oxidative stress markers including FRAP, TBARS, and MPO. " 12/01/2011 - "The results indicated a significant reduction in NF-κB activity as well as the levels of IL-1β, TNF-α, TBARS, protein carbonyl, myeloperoxidase activity, and an improvement in antioxidant power of colitis in treated rats. " 09/01/2004 - "Lactulose treatment ameliorated DSS-induced colitis in a dose-dependent manner, and at 1000 mg/kg all of the parameters examined, except TBARS, were shown to improve significantly as compared to controls. " 09/01/2014 - "The analysis of the values of lipid peroxidation (LPO) obtained by substances that react with thiobarbituric acid (TBARS) showed a significantly increased LPO in the colitis group compared to the control groups (p < 0.001). " 04/01/2009 - "In both groups with colitis, higher values of tert butyl hydroperoxide-initiated-chemiluminescence and thiobarbituric acid-reactive substances in tissue and decreased total radical-trapping antioxidant potential (TRAP) levels in plasma were found. "
4.	Inflammation 06/01/1992 - "In the current studies, the confirmation of inflammation-mediated lipid peroxidation was proceeded further to include measurement of multiple parameters, including conjugated dienes, ketodienes, thiobarbituric acid reactive substances and fluorescent chromolipids. " 01/01/2013 - "The levels of TNF-α, TBARS, GSH and Nitrite were measured in the sciatic nerve as an index of inflammation & oxidative stress. " 01/30/2012 - "Dietary supplementation with ALA reduced MCD diet-induced hepatic lipid accumulation, hepatic inflammation, TBARS, 4-HNE, and plasma ALT and AST levels. " 12/01/2011 - "Although TP significantly decreased intestinal MPO levels and inflammation scores, it neither reverted intestinal TBARS and GSH levels nor ameliorated other histological parameters of the disease. " 01/01/1995 - "Basic antioxidative trace element status and inflammation are therefore not major determinants of TBARS levels in normal and in pathological conditions, despite of the frequent association of low serum Zn and mainly low serum Se with high TBARS levels."
5.	Neoplasms (Cancer) 01/01/2003 - "In addition, subjects affected by cancer exhibited a significant reduction in TBARS levels, were more anxious, had lower total B cells percentage and T helper/T suppressor ratio, and had a higher percentage of natural killer cells. " 11/01/2010 - "The study showed the highest concentration of TBARS in benign, and the lowest in malignant liver tumors. " 01/01/2012 - "The TBARS level was found to be significantly higher (p≤0.001) in all types of cancer patients when compared to controls, being aggravated in alcoholics with a smoking habit. " 01/01/2012 - "TBARS levels were found to be significantly decreased in both ascitic cancer cells compared to the baseline except for in the ascite I of MatLyLu cells. " 01/01/2011 - "Plasma and erythrocyte TBARS level was significantly elevated in the cervical cancer patients compared to normal. "

Related Drugs and Biologics

1.	Thiobarbituric Acid Reactive Substances
2.	Glutathione (Reduced Glutathione)
3.	Superoxide Dismutase
4.	Peroxidase (Myeloperoxidase)
5.	alpha-Tocopherol
6.	Blood Glucose (Blood Sugar)
7.	Catalase
8.	thiobarbituric acid
9.	Enzymes
10.	Ascorbic Acid (Vitamin C)

Related Therapies and Procedures

1.	Oral Administration
2.	Drug Therapy (Chemotherapy)
3.	Chronotherapy
4.	Transplants (Transplant)
5.	Aftercare (After-Treatment)