Interleukin-11 (Interleukin 11)

A lymphohematopoietic cytokine that plays a role in regulating the proliferation of ERYTHROID PRECURSOR CELLS. It induces maturation of MEGAKARYOCYTES which results in increased production of BLOOD PLATELETS. Interleukin-11 was also initially described as an inhibitor of ADIPOGENESIS of cultured preadipocytes.

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Networked: 573 relevant articles (30 outcomes, 102 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ernst, Matthias: 14 articles (10/2015 - 09/2005)
2.	Putoczki, Tracy L: 9 articles (10/2015 - 08/2012)
3.	Keith, J C: 9 articles (01/2005 - 02/2000)
4.	Dimitriadis, Evdokia: 6 articles (12/2015 - 02/2006)
5.	Judd, Louise M: 6 articles (01/2015 - 09/2005)
6.	Giraud, Andrew S: 6 articles (01/2015 - 09/2005)
7.	Elias, Jack A: 6 articles (12/2008 - 03/2003)
8.	Howlett, Meegan: 5 articles (01/2014 - 09/2005)
9.	Guise, Theresa A: 5 articles (12/2012 - 10/2003)
10.	Keith, James C: 5 articles (01/2011 - 01/2003)

Related Diseases

1.	Thrombocytopenia (Thrombopenia) 01/01/1998 - "IL-11 improved the platelet nadir counts and the recovery from thrombocytopenia at a dose of 50 micrograms/kg/day for 14 days. " 01/01/2000 - "Recombinant human interleukin-11 (rhIL-11) is a licensed biological therapeutic product in at least one country and is used to combat thrombocytopenia during chemotherapeutic regimens, as well as undergoing clinical trials for a range of other disorders. " 01/01/2011 - "Since IL-11 is used for patients with thrombocytopenia, we propose that IL-11 is a candidate cytokine clinically available for cardioprotection therapy." 01/01/2011 - "He was treated with IL-11 (3 mg per day) for thrombocytopenia. " 01/01/2011 - "We describe two cases of CLS after IL-11 administration in two males with thrombocytopenia. "
2.	Inflammation 03/01/2003 - "These studies demonstrated that chemokine receptor-2, transforming growth factor-beta(1), and IL-11 play an important role in the regulation of inflammation and remodeling in the IL-13-treated lung. " 01/01/2001 - "Information from these and other preclinical animal models, such as those involving interleukin 11, has led to human trials testing novel therapies for IBD and other diseases in which inflammation of the gut mucosa is an important component. " 10/01/2014 - "Consistent with this, model simulations suggest that periodic IL-11 therapy may result in prolonged low-grade (chronic) inflammation post treatment. " 10/11/2011 - "The combination of SF and OMT showed synergistic anti-inflammatory effect, and the activity was probably related to its modulation on inflammation-associated mediators, especially IL-11, CRP and INF-γ." 12/01/2008 - "Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production."
3.	Necrosis 03/01/1997 - "Protective effects of interleukin-11 in a murine model of ischemic bowel necrosis." 01/01/2015 - "Next, effects of IL-11/STAT3 signaling pathway were assessed in liver IRI, which showed IL-11 treatment significantly attenuated liver IRI, as evidenced by reduced hepatocellular function and hepatocellular necrosis/apoptosis. " 10/15/2012 - "Furthermore, HR IL-11 or PEGylated IL-11 decreased both necrosis and apoptosis in human proximal tubule (HK-2) cells in culture. " 10/15/2012 - "Significant reductions in renal tubular necrosis and neutrophil infiltration as well as tubular apoptosis were observed in mice treated with HR IL-11 or PEGylated IL-11. " 12/01/2002 - "These data indicate that following IR injury, IL-11 improves enterocyte survival by reducing necrosis and apoptosis."
4.	Neoplasms (Cancer) 10/01/2015 - "We review current strategies to interfere with IL-11 signaling and advocate that inhibition of IL-11 signaling may represent an emerging therapeutic opportunity for numerous cancers. " 10/01/2015 - "These include the capacity of IL-11 to stimulate survival and proliferation of cancer cells alongside angiogenesis of the primary tumor and of metastatic progenies at distant organs. " 10/01/2015 - "Accordingly, IL-11 signaling has recently been identified as a rate-limiting step for the growth tumors arising from the mucosa of the gastrointestinal tract. " 10/01/2015 - "In addition of its long recognized activities as a hemopoietic growth factor, IL-11 has an emerging role in epithelial cancer biology. " 05/01/2015 - "IL-11 intensity was assessed by immunohistochemistry in tumor specimens. "
5.	Mucositis 12/01/2002 - "IL-11 (100 microg/kg/twice daily subcutaneously) maintained intestinal weight, and reduced the severity of mucositis, as measured by villus area, crypt length, and mitotic count per crypt. " 12/01/2002 - "The aim of this study was to investigate the time-course and effect of interleukin-11 (IL-11) on apoptosis and intestinal morphometry as measures of mucositis. " 07/01/2000 - "In the current study, we evaluated a series of biologic and morphologic outcomes to determine their roles and sequence in the development of experimental radiation-induced mucositis and to evaluate the effects of IL-11 in attenuating them. " 12/01/2004 - "IL-11 has a significant mitigating effect on high-dose MTX induced intestinal mucositis in rat, and significantly increase the survival of the rats. " 12/01/2002 - "We conclude that IL-11 attenuated mucositis by maintaining intestinal weight and morphometry. "

Related Drugs and Biologics

1.	oprelvekin (Neumega)
2.	Cytokines
3.	Interleukin-10 (Interleukin 10)
4.	Messenger RNA (mRNA)
5.	Interleukin-11 Receptors (Interleukin 11 Receptor)
6.	Carboplatin (JM8)
7.	gemtuzumab (gemtuzumab ozogamicin)
8.	Intravenous Immunoglobulins (IVIG)
9.	Isoflurane
10.	Deamino Arginine Vasopressin (Desmopressin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Platelet Transfusion (Blood Platelet Transfusions)
3.	Stem Cell Transplantation
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Transplants (Transplant)