Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)

A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.

Also Known As:

Networked: 447 relevant articles (4 outcomes, 50 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Delivoria-Papadopoulos, Maria: 8 articles (08/2011 - 02/2005)
2.	Zhang, Li-Cai: 5 articles (11/2015 - 04/2005)
3.	Klemm, Dwight J: 5 articles (04/2014 - 07/2006)
4.	Ashraf, Qazi M: 5 articles (08/2011 - 12/2006)
5.	Wang, Wei: 4 articles (12/2014 - 06/2007)
6.	Garat, Chrystelle V: 4 articles (04/2014 - 07/2006)
7.	Reusch, Jane E B: 4 articles (04/2014 - 04/2010)
8.	Mishra, Om Prakash: 4 articles (08/2011 - 12/2006)
9.	Huang, Chao-Ching: 4 articles (02/2009 - 12/2003)
10.	Chang, Ying-Chao: 4 articles (02/2009 - 12/2003)

Related Diseases

1.	Anoxia (Hypoxia) 05/30/2007 - "The aim of the present study was to understand the importance of neuronal nuclear Ca(2+) in the role of CaM KIV activation and CREB protein phosphorylation associated with hypoxia. " 06/01/2006 - "In this study, we show that hypoxia increases eNOS gene expression through the binding of phosphorylated cAMP-responsive element binding (CREB) protein (pCREB) to the eNOS gene promoter. " 01/01/2002 - "Previous studies have shown that hypoxia results in increased phosphorylation of CREB protein that mediates gene expression including that of the pro-apoptotic gene bax. " 04/01/2008 - "Several putative cis-acting elements including SP1, hypoxia inducible factor (HIF), cAMP-response element binding protein, T-cell factor/lymphocyte enhancer factor 1 (TCF/LEF1), AP1 and the signal transducer and activator of transcription-6 (STAT6) are found in the 5' flanking region of SNAP-25 gene. " 02/01/2008 - "By using this system, the transcriptional activator cyclic-AMP-response-element-binding protein (CREB) was phosphorylated at Ser-133 and the hypoxia-inducible factor-1alpha (HIF-1alpha) was hydroxylated at Asn-803 in E. "
2.	AIDS-Related Complex (ARC) 03/05/2010 - "In this study we tested the hypothesis that altered cAMP response element binding (CREB) protein induction and activity-regulated cytoskeletal-associated gene (Arc) expression may underlie the suppression of hippocampal neurogenesis and memory impairment associated with early sensorimotor deprivation. " 08/01/2015 - "CREB (cAMP-response element-binding protein) signaling, Arc and brain-derived neurotrophic factor, which play important roles in synaptic plasticity and adaptive cellular stress responses, were up-regulated in response to DNP, and DNP-treated mice exhibited improved performance in a test of learning and memory. " 01/01/2014 - "Arc is regulated by the transcription factor cAMP response element binding protein, which is upregulated with and necessary for fear extinction. " 01/01/2013 - "Both the activity of neurons, which was evaluated by immunohistochemical detection for phosphorylated-cAMP response element binding protein (pCREB), and NPY mRNA levels in the caudal ARC were higher at 0.5 hr after lights on than the other two time points, while pCREB-positive cell numbers in the rostral ARC remained unchanged throughout the experimental period. " 10/01/2005 - "During this period, there was a time-dependent increase in phosphorylation of cAMP response element-binding protein (CREB) in the dorsal hippocampus and amygdala and increased synthesis of activity-regulated cytoskeletal-associated protein (Arc) in the dorsal hippocampus, amygdala, frontal cortex and occipital cortex. "
3.	Lymphoma (Lymphomas) 05/01/2007 - "Although it has been proposed that exposure to lithium up-regulates brain-derived neurotrophic factor (BDNF), B-cell leukaemia/lymphoma 2 protein (Bcl-2) and cyclic AMP-response element-binding protein (CREB), and these molecules are involved in the neuroplastic actions and clinical efficacy of the drug, the several lines of evidence suggest that the lithium-induced up-regulation of these molecules has not been consistently confirmed. " 07/01/2012 - "We investigated the effect of VPA (200 mg/kg, every 12 h) in sleep deprivation (SD) rats (72 h), the manic-like animal model, focusing on the N-methyl-D: -aspartic acid (NMDA) receptor and signaling mediators of synaptic plasticity such as extracellular signal-regulated protein kinase (ERK), cAMP response element-binding protein (CREB), B cell chronic lymphocytic leukemia/lymphoma 2 (BCL2), and brain-derived neurotrophic factor (BDNF). "
4.	Neuralgia (Stump Neuralgia) 10/01/2014 - "The present study aims to elucidate the cyclic AMP response element-binding protein (CREB)-mediated upregulation of Cdk5 and its functional significance in rats with neuropathic pain induced by chronic constriction injury (CCI) in the sciatic nerve. " 07/01/2013 - "The aim of the present study was to determine whether the cAMP response element binding protein (CREB) contributes to neuropathic pain during development stage. " 04/25/2005 - "Few studies have explored the relationship between ERK and cAMP response-element binding protein (CREB) in neuropathic pain after nerve injury, such as chronic constriction injury (CCI) of the sciatic nerve. " 01/01/2014 - "The cyclic AMP response element-binding protein (CREB) plays an important role in neuropathic pain. " 07/01/2013 - "Intrathecal administration of cyclic AMP response element-binding protein-antisense oligonucleotide attenuates neuropathic pain after peripheral nerve injury and decreases the expression of N-methyl-D-aspartic receptors in mice."
5.	Ischemia 09/01/2008 - "Our previous studies have demonstrated that pharmacological activation of the cAMP response element-binding protein (CREB) signaling pathway, before hypoxic-ischemia protected against neuronal injury in neonatal rats. " 02/01/2009 - "We examined whether rapid, intermediate, and delayed IP against hypoxic-ischemia (HI) could be induced in neonatal brain, and if so, whether the IP involved phosphorylation of cAMP response element-binding protein (pCREB) after HI. " 12/01/2007 - "These results suggest that reduced nNOS is involved in ischemia-induced hippocampal neurogenesis by up-regulating iNOS expression and cAMP response element-binding protein phosphorylation." 07/01/2001 - "In isolated, perfused adult rat hearts, global ischemia increased the phosphorylation of cAMP response element-binding protein (CREB) relative to control levels, and this phosphorylation was reversed with reperfusion. " 08/02/1999 - "The phosphorylation of cAMP response element binding protein (CREB) in the rat brain was examined immunohistochemically at 3.5 h, 12 h, 24 h and 48 h of recirculation after focal ischemia induced by occlusion of the middle cerebral artery for 1.5 h. "

Related Drugs and Biologics

1.	Brain-Derived Neurotrophic Factor (BDNF)
2.	DNA (Deoxyribonucleic Acid)
3.	CREB-Binding Protein
4.	Estrogens (Estrogen)
5.	Activating Transcription Factor 1
6.	Lithium
7.	Iron
8.	Chelating Agents
9.	A-factor (Streptomyces)
10.	Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1.	Ligation
2.	Spinal Injections
3.	Electroacupuncture
4.	Heterologous Transplantation (Xenotransplantation)
5.	Therapeutics