Cyclotrons

Devices for accelerating charged particles in a spiral path by a constant-frequency alternating electric field. This electric field is synchronized with the movement of the particles in a constant magnetic field.

Also Known As:

Networked: 311 relevant articles (8 outcomes, 44 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Laskin, Julia: 15 articles (06/2016 - 02/2003)
2.	Li, Zhili: 11 articles (01/2020 - 12/2012)
3.	Qin, Xuzhen: 7 articles (07/2014 - 12/2012)
4.	Qiu, Ling: 7 articles (07/2014 - 12/2012)
5.	Guo, Shuai: 6 articles (06/2015 - 12/2012)
6.	Han, Fei: 5 articles (01/2021 - 09/2017)
7.	Wang, Yanmin: 5 articles (01/2016 - 08/2013)
8.	Liu, Hui: 5 articles (07/2014 - 12/2012)
9.	Yang, Zhibo: 5 articles (04/2011 - 03/2008)
10.	Futrell, Jean H: 5 articles (05/2006 - 02/2003)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2005 - "Finally, a calculated catchment size of 567,000 people would support the use of a PET center with cyclotron The use of PET for the staging of cancer appears to be cost effective in most jurisdictions in Canada." 01/01/1978 - "Improvement in beam current performance of the biomedical cyclotron at Memorial Sloan-Kettering Cancer Center." 02/01/2014 - "Design study of electron cyclotron resonance-ion plasma accelerator for heavy ion cancer therapy." 02/01/2014 - "A study on prevention of an electric discharge at an extraction electrode of an electron cyclotron resonance ion source for cancer therapy." 05/01/2001 - "More cyclotrons could thereby deliver quantities useful for clinical cancer trials."
2.	Glioma (Gliomas) 08/01/2020 - "Phase 1 and 2 clinical trials have been performed for recurrent malignant gliomas using accelerator-based neutron sources, and now fortunately, a cyclotron-based neutron generator has been approved as a medical device by Japanese regulatory authority, as the world's first accelerator-based BNCT system for medical use. " 09/01/2001 - "Twenty patients with Grade 2/4 (n = 7) and Grade 3/4 (n = 13) gliomas according to the Daumas-Duport classification were treated on a prospective institutional protocol at Massachusetts General Hospital/Harvard Cyclotron Laboratory between 1993 and 1996. " 01/01/2021 - "This study aimed to assess the safety and efficacy of accelerator-based BNCT (AB-BNCT) using a cyclotron-based neutron generator (BNCT 30) and 10B-boronophenylalanine (SPM-011) in patients with recurrent malignant glioma (MG) (primarily glioblastoma [GB]). " 04/01/1981 - "The combination of cyclotron fast-neutron radiotherapy with BCNU chemotherapy was compared to 137Cs gamma photon radiotherapy combined with BCNU in the 36B-10, F-344 rat-transplanted glioma model. " 06/01/2014 - "[(11)C] methionine (MET) is an amino acid tracer with low accumulation in normal brain which can detect low grade gliomas, but its short 20 min half life has limited its use to imaging sites with their own cyclotron. "
3.	Alzheimer Disease (Alzheimer's Disease) 08/01/2020 - "In order to investigate the protective effects of Rhodiola crenulata extract on Alzheimer's disease, a brain metabolomics study in rats was conducted by high performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry. " 08/01/2020 - "Brain metabolomics study for the protective effects of Rhodiola crenulata extract on Alzheimer's disease by HPLC coupled with Fourier transform-ion cyclotron resonance mass spectrometry." 01/15/2021 - "Rhodiola crenulata protects against Alzheimer's disease in rats: A brain lipidomics study by Fourier-transform ion cyclotron resonance mass spectrometry coupled with high-performance reversed-phase liquid chromatography and hydrophilic interaction liquid chromatography." 03/20/2019 - "A metabolomic strategy based on accurate mass and isotopic fine structures (IFSs) by dual mode combined-Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) was established to explore the effects of Rhodiola crenulata extract (RCE) on Alzheimer disease (AD) in rats. "
4.	Sarcoma (Soft Tissue Sarcoma) 09/01/1988 - "Between November 1980 and June 1981, 14 patients with soft-tissue sarcoma were entered into a prospective randomized trial comparing the efficacy of megavoltage photon irradiation with cyclotron-generated fast neutrons as post-operative adjuvant therapy. " 04/01/1989 - "The results of fast neutron therapy of soft tissue sarcoma at the cyclotron of Louvain-la-Neuve are reviewed. " 10/01/1987 - "Seventy-nine patients with soft tissue sarcoma were treated with fast neutron therapy at the Hammersmith Hospital, MRC Cyclotron Unit. " 12/01/1985 - "Between March 1978 and October 1983, 65 patients with locally advanced soft tissue sarcomas were treated at the cyclotron of Louvain-la-Neuve. " 08/01/1987 - "Investigations in proton beam therapy of cancer patients have been initiated at the Cyclotron Laboratory, Harvard University, Cambridge, USA, since 1974 using a proton beam with the energy of 160 MeV for fractionated irradiation of uveal melanoma (899 cases), chordoma and chondrosarcoma of the base of the skull (96), sarcoma of the soft tissues and bones (79), prostatic cancer, head and neck tumors, etc. (altogether 1331 patients had been irradiated by June, 1986). "
5.	Glioblastoma (Glioblastoma Multiforme) 01/01/2021 - "This study aimed to assess the safety and efficacy of accelerator-based BNCT (AB-BNCT) using a cyclotron-based neutron generator (BNCT 30) and 10B-boronophenylalanine (SPM-011) in patients with recurrent malignant glioma (MG) (primarily glioblastoma [GB]). "

Related Drugs and Biologics

1.	Radioisotopes (Radionuclides)
2.	Helium
3.	Titanium
4.	Vanadium-48
5.	Lipids
6.	Ammonia
7.	Proteins (Proteins, Gene)
8.	Peptides (Polypeptides)
9.	Ions
10.	Protons (Proton)

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Radiotherapy
4.	Imaging Phantoms
5.	Boron Neutron Capture Therapy