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Protein-Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)

Subscribe to New Research on Protein-Serine-Threonine Kinases

A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.

Also Known As:

Protein-Serine-Threonine Kinase; Serine Kinase; Serine-Threonine Kinases; Kinases, Serine-Threonine; Protein Kinases, Serine-Threonine; Serine-Threonine Protein Kinases; Protein-Serine Kinase; Protein-Threonine Kinase; Serine-Threonine Kinase; Threonine Kinase; Kinase, Protein-Serine; Kinase, Protein-Serine-Threonine; Kinase, Protein-Threonine; Kinase, Serine; Kinase, Serine-Threonine; Kinase, Threonine; Kinases, Protein-Serine-Threonine; Kinases, Serine-Threonine Protein; Protein Serine Kinase; Protein Serine Threonine Kinase; Protein Serine Threonine Kinases; Protein Threonine Kinase; Serine Threonine Kinase; Serine Threonine Kinases; Serine Threonine Protein Kinases

Networked: 1353 relevant articles (3 outcomes, 66 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Phosphotransferases: 30637
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9706
        Protein-Serine-Threonine Kinases: 1353
        Protein Kinase C: 4783
        rho-Associated Kinases: 1279
        AMP-Activated Protein Kinases: 1076
        Mitogen-Activated Protein Kinases: 952
        Proto-Oncogene Proteins c-akt: 945
        aurora kinase: 684
        Cyclin-Dependent Kinases: 639
        Glycogen Synthase Kinases: 435
        I-kappa B Kinase: 417
        DNA-Activated Protein Kinase: 314
        transforming growth factor-beta type II receptor: 293
        Ribosomal Protein S6 Kinases: 292
        integrin-linked kinase: 286
        eIF-2 Kinase: 244
        polo-like kinase 1: 241
        ataxia telangiectasia mutated protein: 226
        Activin Receptors: 225
        Calcium-Calmodulin-Dependent Protein Kinases: 215
        Mitogen-Activated Protein Kinase Kinases: 196
        myotonic dystrophy protein kinase: 196
        pyruvate dehydrogenase (acetyl-transferring) kinase: 148
        p21-Activated Kinases: 124
        Bone Morphogenetic Protein Receptors: 116
        Interleukin-1 Receptor-Associated Kinases: 108
        checkpoint kinase 2: 101
        Casein Kinases: 99
        TGF-beta type I receptor: 94
        Positive Transcriptional Elongation Factor B: 68
        MAP-kinase-activated kinase 2: 63
        Lim Kinases: 62
        TOR Serine-Threonine Kinases: 52
        Proto-Oncogene Proteins c-pim-1: 47
        3-phosphoinositide-dependent protein kinase: 45
        G-Protein-Coupled Receptor Kinases: 45
        Receptor-Interacting Protein Serine-Threonine Kinases: 42
        serum-glucocorticoid regulated kinase: 38
        NF-kappa B kinase: 35
        Dyrk kinase: 29
        MAP Kinase Kinase Kinases: 29
        Proline-Directed Protein Kinases: 26
        rat Snf1lk protein: 24
        PDZ-binding kinase: 16
        protein kinase P: 15
        SNF1-related protein kinases: 13
        hematopoietic progenitor kinase 1: 8
        PAS domain kinases: 7
        Phytochrome A: 7
        citron-kinase: 6
        MAP-kinase-activated kinase 3: 6
        tau-tubulin kinase: 6
        NIMA protein kinase: 5
        MAP-kinase-activated kinase 5: 4
        Proto-Oncogene Proteins c-bcr: 3
        germinal center kinases: 2
        HPr kinase: 1
        human CDC7 protein: 1
        mouse Lrrk2 protein: 1
        Oncogene Protein v-akt: 1
        phosphoenolpyruvate carboxylase kinase: 1
        vimentin kinase: 1
        60S ribosomal protein kinase
        actin kinase
        Amycolatopsis mediterranei PkmA protein
        Anabaena PknC protein
        Arabidopsis ADK1 protein
        Arabidopsis APK1A protein
        Arabidopsis APK2a protein
        Arabidopsis ASK10 protein
        Arabidopsis ATHLECRK protein
        Arabidopsis atpk1 protein
        Arabidopsis ATR protein
        Arabidopsis AtSR1 protein
        Arabidopsis AUR1 protein
        Arabidopsis AUR2 protein
        Arabidopsis AUR3 protein
        Arabidopsis BAK1 protein
        Arabidopsis BAM1 protein
        Arabidopsis BAM2 protein
        Arabidopsis BIK1 protein
        Arabidopsis Cak1at protein
        Arabidopsis CBRLK1 protein
        Arabidopsis CERK1 protein
        Arabidopsis CIPK1 protein
        Arabidopsis CIPK23 protein
        Arabidopsis CIPK3 protein
        Arabidopsis CRK5 protein
        Arabidopsis ER protein
        Arabidopsis extrasporogenous cells protein
        Arabidopsis GRIK1 protein
        Arabidopsis GRIK2 protein
        Arabidopsis LecRK2 protein
        Arabidopsis MAP3Kepsilon1 protein
        Arabidopsis OXI1 protein
        Arabidopsis PBS1 protein
        Arabidopsis PINOID protein
        Arabidopsis PKS4 protein
        Arabidopsis PKS5 protein
        Arabidopsis PR5K protein
        Arabidopsis RLK4 protein
        Arabidopsis RLK5 protein

Experts

1.	Kahle, Kristopher T: 9 articles (06/2008 - 01/2003)
2.	Lifton, Richard P: 9 articles (06/2008 - 01/2003)
3.	Shaw, Reuben J: 8 articles (08/2014 - 03/2004)
4.	Friedman, Eileen: 7 articles (07/2011 - 12/2003)
5.	Sen, Subrata: 7 articles (04/2011 - 03/2003)
6.	Marais, Richard: 6 articles (03/2013 - 06/2002)
7.	Lahn, Michael: 6 articles (06/2011 - 08/2007)
8.	Hebert, Steven C: 6 articles (06/2008 - 01/2003)
9.	Mukaida, Naofumi: 5 articles (12/2015 - 03/2005)
10.	Yu, Long: 5 articles (02/2015 - 06/2007)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2013 - "Previous studies have identified gene rearrangements in the microtubule-associated serine-threonine kinase (MAST) and NOTCH gene families in 5% to 7% of invasive breast cancers. " 10/01/2012 - "After reviewing this basic information, we will examine newer studies that demonstrate the pathophysiological consequences to SPAK and/or OSR1 disruption, discuss the development and analysis of genetically engineered mouse models, and address the possible role these serine/threonine kinases might have in cancer proliferation and migration." 02/01/2005 - "Recent studies indicate that dysregulation of the Akt/PKB family of serine/threonine kinases is a prominent feature of many human cancers. " 11/01/1997 - "All of the mutations in the present study occurred within the highly conserved serine/threonine kinase domain and represent the first report of such 'direct' TbetaR-II mutations in primary human tumors. " 11/01/2015 - "The serine/threonine kinase LKB1 is a well-characterized tumor suppressor that governs diverse cellular processes, including growth, polarity, and metabolism. "
2.	Insulin Resistance 04/09/1999 - "The current study investigated serine kinase activity toward IRS-1 in several models of insulin resistance. " 12/01/2012 - "These results indicate that activation of the serine kinase JNK contributes, at least in part, to oxidative stress-induced insulin resistance in isolated mammalian skeletal muscle." 03/06/2009 - "The serine/threonine kinase Akt is a focal point in signaling pathways that control cell tumorigenesis and insulin resistance. " 09/01/2002 - "Reversal of the impaired IR signaling by inhibitors of serine kinase activity suggests that serine kinase-mediated pathways may be involved in the insulin resistance. " 04/09/1999 - "Identification of enhanced serine kinase activity in insulin resistance."
3.	Melanoma (Melanoma, Malignant) 08/01/2009 - "Mutational profiling studies have shown that the majority of melanomas harbor activating mutations in the serine/threonine kinase BRAF at the V600E position. " 08/01/2015 - "The results suggest that serine/threonine kinases may be viable therapeutic targets for the treatment of canine malignant melanoma." 01/01/2015 - "Mutations in the serine/threonine kinase BRAF are found in more than 60% of melanomas. " 01/01/2015 - "MAP3K7 (known as TAK1), a serine/threonine kinase along the MAPK signaling pathway, was over-expressed in melanoma but decreased following ectopic expression of miR-377. " 04/01/2014 - "Vemurafenib is a small molecule inhibitor of the BRAF serine-threonine kinase recently approved by the United States Food and Drug Administration to treat patients with metastatic and unresectable melanomas that carry an activating BRAF (V600E) mutation. "
4.	Inflammation 01/08/2015 - "IRAK4, a serine/threonine kinase, plays a key role in both inflammation and oncology diseases. " 05/15/2012 - "Thus, the double-edged sword effect of inhibition of NF-κB via inhibition of both serine/threonine kinase and PTK by biochanin might show useful therapeutic value against activities of cells that lead to tumorigenesis and inflammation." 04/13/2012 - "Bcr is a serine/threonine kinase that is a critical regulator of vascular smooth muscle cell inflammation and proliferation. " 04/01/2010 - "The molecular mechanisms that contribute to this inflammation are still somewhat unclear, but several serine/threonine kinases are known to be involved. " 05/01/2002 - "Recent studies have implicated fatty acid-dependent activation of the serine kinase IKKbeta, which plays a key role in tissue inflammation, in the pathogenesis of insulin resistance. "
5.	Hematologic Neoplasms (Hematological Malignancy) 01/01/2015 - "The Pims are a small family of serine/threonine kinases with increased expression across the hematological malignancies. " 12/01/2012 - "Pim1 is a unique, constitutively active serine/threonine kinase, and is a potent oncogene overexpressed in a range of hematologic malignancies and solid cancers. " 06/01/2010 - "PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers." 11/12/2009 - "Pim-1, Pim-2, and Pim-3 are a family of serine/threonine kinases which have been found to be overexpressed in a variety of hematopoietic malignancies and solid tumors. " 06/01/2010 - "Here, we summarize the current knowledge about the role of PIM serine/threonine kinases for the pathogenesis and therapy of hematologic malignancies and solid cancers, and we highlight structural principles and recent progress on small molecule PIM kinase inhibitors that are on their way into first clinical trials."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Protein-Tyrosine Kinases (Tyrosine Kinase)
3.	6-pyruvoyltetrahydropterin synthase (PTPS)
4.	Insulin (Novolin)
5.	Sirolimus (Rapamycin)
6.	Protein Kinases (Protein Kinase)
7.	Tyrosine (L-Tyrosine)
8.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
9.	Glycogen Synthase (Synthase I)
10.	Transforming Growth Factor beta (TGF-beta)

Related Therapies and Procedures

1.	Caloric Restriction
2.	Therapeutics
3.	Phacoemulsification
4.	Drug Therapy (Chemotherapy)
5.	Radiotherapy