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Loratadine (Alavert)

A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.

Also Known As:

Alavert; Claritin; Clarium; 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester; Sch-29851; Wyeth Brand of Loratadine; Loratadine Wyeth Brand; Sch 29851; Sch29851; 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester

Networked: 345 relevant articles (86 outcomes, 112 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Lu, Susan: 4 articles (11/2010 - 06/2002)
2.	Day, James H: 3 articles (01/2013 - 04/2009)
3.	Reiss, Theodore F: 3 articles (11/2009 - 06/2002)
4.	Yao, Ruji: 3 articles (05/2009 - 04/2009)
5.	Danzig, Melvyn: 3 articles (05/2009 - 04/2009)
6.	Nørgaard, Mette: 3 articles (03/2008 - 01/2006)
7.	Sørensen, Henrik Toft: 3 articles (03/2008 - 01/2006)
8.	Pedersen, Lars: 3 articles (03/2008 - 01/2006)
9.	Ratner, P: 3 articles (04/2004 - 03/2003)
10.	Hampel, F: 3 articles (04/2004 - 03/2003)

Related Diseases

1.	Seasonal Allergic Rhinitis (Hay Fever) 09/01/1994 - "Prophylactic loratadine therapy was effective in suppressing symptoms of seasonal allergic rhinitis and providing patients with symptom-free days throughout the pollen season." 12/01/1991 - "We conclude that loratadine and intranasal BDP were effective in the treatment of seasonal allergic rhinitis, but the spectrum of individual symptoms controlled was different for the 2 drugs." 12/01/1990 - "Thus loratadine is an effective and safe antihistamine when given once daily for the symptomatic relief of seasonal allergic rhinitis." 08/01/1989 - "Loratadine appears to be a simple, effective and safe therapy for seasonal allergic rhinitis." 05/01/2000 - "The primary objective of the study was to compare the safety and efficacy of TAA aqueous with loratadine in relieving the symptoms of seasonal allergic rhinitis. "
2.	Rhinitis 05/01/2014 - "The primary end point was the improvement in Rhinitis Quality of Life (RQLQ) global score at the fifth week of LP-33 consumption compared with placebo (in addition to loratadine). " 03/01/1987 - "Loratadine 40 mg once daily was effective and safe in the relief of symptoms of allergic rhinitis." 09/01/2001 - "This study revealed that loratadine syrup 5 mg or 10 mg once a day improved symptom scores of children with allergic rhinitis effectively and safely." 09/01/2001 - "Controlled clinical study of the efficacy of loratadine in Nigerian patients with allergic rhinitis." 01/01/2014 - "In this study, 24 patients suffering from persistent allergic rhinitis induced by house dust mites were treated either with acupuncture (n = 15) or with loratadine (n = 9). "
3.	Urticaria (Hives) 02/01/1990 - "We concluded that loratadine, 10 mg, once daily is a safe and effective treatment for symptomatic relief of chronic idiopathic urticaria." 12/01/1996 - "Safety and efficacy of loratadine in urticaria." 04/04/1994 - "This study aimed at evaluating loratadine efficiency versus placebo in the treatment of patients with chronic urticaria. " 01/01/2011 - "After an SBPCOC with loratadine, the patient developed generalized urticaria 90 minutes after intake. " 01/01/2005 - "OTC product: Loratadine for urticaria."
4.	Perennial Allergic Rhinitis 02/01/1989 - "Loratadine, a new nonsedating antihistamine, was evaluated for efficacy and safety in 228 patients with perennial allergic rhinitis. " 02/01/1989 - "Evaluation of the efficacy and safety of loratadine in perennial allergic rhinitis." 11/01/1997 - "In contrast, loratadine, a potent, nonsedating, histamine-1-receptor antagonist with activity in seasonal and perennial allergic rhinitis, has demonstrated effective control of asthma symptoms, improved pulmonary function, and long duration of action in patients with allergic bronchial asthma. " 05/01/1990 - "The study showed that compared with placebo both loratadine and clemastine were effective in relieving nasal and eye symptoms in patients with perennial allergic rhinitis. " 04/01/2009 - ": The combination of loratadine and betamethasone in an oral solution was safe and effective as initial short-term treatment for symptoms of severe perennial allergic rhinitis in school-aged children."
5.	Pruritus (Itching) 08/01/1991 - "Prophylactic administration of loratadine to 15% of our patients was not shown to be effective in diminishing the incidence of pruritus." 07/01/2000 - "Loratadine decreased the size of the wheals by 45% (P < 0.001, 25 children) and accompanying pruritus by 78% (P = 0.011, 12 children) at 15 min compared to placebo. " 01/01/1994 - "The aim of the study was to assess the therapeutic efficacy of loratadine on pruritus in patients with atopic dermatitis, considering the patients' sensation of itch. " 07/01/2005 - "These results indicate that loratadine may be effective in preventing pruritus associated with atopic dermatitis." 11/01/1989 - "Loratadine was particularly effective compared with placebo in relieving nasal discharge, sneezing, and itching/burning eyes. "

Related Drugs and Biologics

1.	Cetirizine (Zyrtec)
2.	Terfenadine (Seldane)
3.	montelukast (Singulair)
4.	Pseudoephedrine
5.	ebastine (Kestin)
6.	Astemizole
7.	Loratadine (Alavert)
8.	mizolastine (Zolim)
9.	Histamine Antagonists (Antihistamines)
10.	zafirlukast (Accolate)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Oral Administration
3.	Acupuncture Points (Acupuncture Point)
4.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
5.	Heterologous Transplantation (Xenotransplantation)