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Cetirizine (Zyrtec)

A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.

Also Known As:

Zyrtec; P071; P 071; (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic Acid; AWD.pharma Brand of Cetirizine Dihydrochloride; Alerlisin; Aliud Brand of Cetirizine Dihydrochloride; Alpharma Brand of Cetirizine Dihydrochloride; Azupharma Brand of Cetirizine Dihydrochloride; Basics Brand of Cetirizine Dihydrochloride; Cetalerg; Ceterifug; Ceti TAD; Ceti-Puren; CetiLich; Cetiderm; Cetidura; Cetil von ct; Cetirigamma; Cetirizin AL; Cetirizin AZU; Cetirizin Basics; Cetirizine Dihydrochloride; Cetirlan; Dermapharm Brand of Cetirizine Dihydrochloride; Glaxo Wellcome Brand of Cetirizine Dihydrochloride; Krewel Brand of Cetirizine Dihydrochloride; Lacer Brand of Cetirizine Dihydrochloride; Lichtenstein Brand of Cetirizine Dihydrochloride; Menarini Brand of Cetirizine Dihydrochloride; Merck dura Brand of Cetirizine Dihydrochloride; P-071; Pfizer Brand of Cetirizine Dihydrochloride; Pfizer Consumer Healthcare Brand of Cetirizine Dihydrochloride; Reactine; Rodleben Brand of Cetirizine; Sanofi Synthelabo Brand of Cetirizine Dihydrochloride; TAD Brand of Cetirizine Dihydrochloride; UCB Brand of Cetirizine Dihydrochloride; UCB Pharma Brand of Cetirizine Dihydrochloride; United Drug Brand of Cetirizine Dihydrochloride; Virlix; Voltric; Wolff Brand of Cetirizine Dihydrochloride; Wörwag Brand of Cetirizine Dihydrochloride; Zetir; Zirtek; ct-Arzneimittel Brand of Cetirizine Dihydrochloride; Dihydrochloride, Cetirizine; Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-

Networked: 549 relevant articles (123 outcomes, 172 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperazines: 18
    - Hydroxyzine: 273
      - Cetirizine: 549
        levocetirizine: 159
        NCX 1512
        NCX 1514

Experts

1.	Chapman, Douglass: 5 articles (09/2006 - 11/2002)
2.	Nathan, Robert A: 4 articles (07/2014 - 11/2002)
3.	Kamei, Chiaki: 4 articles (10/2013 - 11/2003)
4.	Horak, Friedrich: 4 articles (05/2010 - 01/2004)
5.	Wilson, A M: 4 articles (01/2007 - 10/2000)
6.	Lipworth, B J: 4 articles (01/2007 - 10/2000)
7.	Kramer, Benjamin: 4 articles (07/2005 - 11/2002)
8.	Goindi, Shishu: 3 articles (09/2014 - 12/2013)
9.	Kaur, Amanpreet: 3 articles (09/2014 - 12/2013)
10.	Day, James H: 3 articles (01/2013 - 01/2004)

Related Diseases

1.	Urticaria (Hives) 04/01/2013 - "Double dose of cetirizine hydrochloride is effective for patients with urticaria resistant: a prospective, randomized, non-blinded, comparative clinical study and assessment of quality of life." 07/01/2001 - "The results of the present study suggest that cetirizine may represent an effective and safe pharmacologic therapy for chronic urticaria in preschool children. " 08/01/2008 - "Cetirizine as an initial treatment for chronic urticaria appears effective and safe. " 05/01/1991 - "The efficacy of cetirizine dihydrochloride, a new H1-antagonist claimed to have minimal sedative property was evaluated in 28 patients with chronic idiopathic urticaria. " 07/01/1988 - "The efficacy of cetirizine dihydrochloride, a new H1-antagonist with minimal sedative or anticholinergic side effects was evaluated in 30 patients with chronic idiopathic urticaria. "
2.	Rhinitis 12/01/1995 - "It is concluded that the amount of sulfidoleukotrienes produced by blood leukocytes in vitro may reflect the nasal hyperreactivity of the patient, and that cetirizine, which is highly effective in the treatment of allergic rhinitis, owes part of its effect to inhibition of sulfidoleukotriene releasability by blood leukocytes in children." 05/01/1995 - "Placebo-treated patients experienced a worsening of rhinitis symptoms from baseline throughout the study, whereas cetirizine-treated patients had a significant improvement in rhinitis symptoms at week 1, which was maintained after onset of the pollen season. " 08/01/1996 - "After 6 weeks of treatment, percentage of days without rhinitis or with only mild rhinitis symptoms was significantly greater in the cetirizine group in comparison with the placebo group (p < 0.0001, Mann-Whitney U test). " 01/01/1992 - "Cetirizine was significantly more effective than placebo in reducing the clinical symptoms of rhinitis near in 60% patients. " 04/01/1995 - "The efficacy of cetirizine was compared with that of previous pharmacologic therapy in patients with allergic rhinitis. "
3.	Seasonal Allergic Rhinitis (Hay Fever) 03/01/1990 - "Cetirizine at a single dose of 10 mg displayed equal efficacy in controlling hayfever symptoms but, in common with other studies, had a significantly greater incidence of drowsiness (p = 0.046)." 04/01/1997 - "Once-daily cetirizine effective in the treatment of seasonal allergic rhinitis in children aged 6 to 11 years: a randomized, double-blind, placebo-controlled study." 07/01/2015 - "FPNS and cetirizine were equally effective in treating fall seasonal allergic rhinitis during a 2-week head-to-head treatment investigation. " 05/01/1998 - "Cetirizine is well tolerated and effective in reducing symptoms of seasonal allergic rhinitis in patients undergoing controlled pollen challenge." 11/01/2002 - "The objective of this study was to evaluate the health-related quality of life (HRQL) effects, safety and efficacy of cetirizine in the treatment of seasonal allergic rhinitis, and impact on self-reported work/school-related productivity and activity impairment (WPAI). "
4.	Pruritus (Itching) 10/01/1993 - "The new H1-receptor antagonist, cetirizine, is eliminated primarily unchanged by renal excretion and is thus potentially useful for relief of pruritus in patients with hepatic dysfunction, in whom many H1-receptor antagonists are contraindicated. " 01/01/2012 - "An open clinical trial on the efficacy of cetirizine hydrochloride in the management of allergic pruritus in cats." 11/01/2002 - "The skin lesions and pruritus cleared quickly after the administration of cetirizine hydrochloride." 05/01/2004 - "The pruritus was satisfactorily reduced in 4/22 (18%) dogs that completed the trial with cetirizine. " 03/01/1990 - "In a double-blind and placebo-controlled study, 11 subjects underwent a conjunctival provocation test (CPT) with a grass pollen extract to determine the effect of cetirizine on allergen-induced itching and redness of the eye. "
5.	Perennial Allergic Rhinitis 01/01/1996 - "This study has shown an overall improvement in the symptoms of perennial allergic rhinitis in patients who were treated with ZYRTEC in conditions similar to those of usual medical practice by pediatricians and allergologists." 04/01/1992 - "A double-blind, placebo-controlled trial was undertaken to assess the safety and efficacy of once daily cetirizine in alleviating the symptoms of perennial allergic rhinitis. " 06/01/1999 - "[The efficacy of cetirizine in the treatment of perennial allergic rhinitis]." 06/01/2004 - "This study shows the cetirizine effectiveness in exerting anti-inflammatory activity by modulating cytokine pattern and by reducing inflammatory infiltration in children with perennial allergic rhinitis." 08/01/1996 - "This study is the first to demonstrate that an H1-blocker, cetirizine, can improve quality of life for patients with perennial allergic rhinitis."

Related Drugs and Biologics

1.	Loratadine (Alavert)
2.	Terfenadine (Seldane)
3.	Cetirizine (Zyrtec)
4.	ebastine (Kestin)
5.	Astemizole
6.	Histamine Antagonists (Antihistamines)
7.	fexofenadine (Allegra)
8.	Hydroxyzine (Vistaril)
9.	Histamine (Histamine Dihydrochloride)
10.	montelukast (Singulair)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Oral Administration
4.	Drug Prescriptions
5.	Subcutaneous Injections