Hematoporphyrin Derivative

A complex mixture of monomeric and aggregated porphyrins used in the photodynamic therapy of tumors (HEMATOPORPHYRIN PHOTORADIATION). A purified component of this mixture is known as DIHEMATOPORPHYRIN ETHER.

Also Known As:

Networked: 504 relevant articles (13 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jain, Viney: 3 articles (07/2011 - 01/2002)
2.	Chekulayev, Vladimir A: 3 articles (11/2008 - 06/2004)
3.	Chekulayeva, Lyudmila V: 3 articles (11/2008 - 06/2004)
4.	Shevchuk, Igor N: 3 articles (11/2008 - 06/2004)
5.	Smolle-Jüttner, F M: 3 articles (10/2001 - 01/2001)
6.	Tomaselli, F: 3 articles (10/2001 - 01/2001)
7.	Maier, A: 3 articles (10/2001 - 01/2001)
8.	Pinter, H: 3 articles (10/2001 - 01/2001)
9.	Sharma, R K: 3 articles (08/2000 - 03/2000)
10.	Muralidhar, K: 2 articles (07/2011 - 06/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/09/2008 - "Porphyrin conjugate 2 was more tumor selective than the hematoporphyrin derivative and accumulated to a significantly greater extent in tumors. " 01/01/1983 - "The efficacy of 99mTc-labeled hematoporphyrin derivative in localizing neoplasms has been investigated with tumor-bearing animal models. " 08/01/2006 - "The object of the present study was the ultrafast photodynamic processes of hematoporphyrin derivative (HPD) for diagnosis and therapy of cancer. " 06/01/1985 - "[Studies on the distribution of a hematoporphyrin derivative (Jiguang No 3) in tumor tissue and organs and its correlation with photodynamic effects]." 03/01/1985 - "Tissue biodistribution studies with tritiated hematoporphyrin derivative, given with doses of 10 and 20 mg per kg of HpD, showed higher concentrations of the dye in the liver, kidneys and spleen than in the tumor at 48 hr after administration of the dye.(ABSTRACT TRUNCATED AT 250 WORDS)"
2.	Carcinoma (Carcinomatosis) 02/01/1979 - "Photoradiation, with the use of hematoporphyrin derivative (Hpd) activated by visible light in the red region of the spectrum, was an effective treatment for controlling local and regional chest wall recurrences of breast carcinoma. " 05/01/1988 - "[Pathologic study on the treatment-effect of hematoporphyrin derivative in carcinoma of the gastric cardia]." 04/01/1985 - "Hairless mice with subcutaneously transplanted Lewis Lung carcinomas were used to study the effects of treatments with hematoporphyrin derivative (HPD) administered by intratumoral injection, followed by exposure to red light. " 08/16/1993 - "Human bladder transitional carcinoma cells, clone T24, were incubated with hematoporphyrin derivative and subsequently exposed to red light. " 03/01/1984 - "Cystoscopic fluorescence detector for photodetection of bladder carcinoma with hematoporphyrin derivative."
3.	Urinary Bladder Neoplasms (Bladder Cancer) 04/01/1990 - "Subcellular localization of hematoporphyrin derivative in bladder tumor cells in culture." 11/01/1988 - "Photodynamic effect in an experimental bladder tumor treated with intratumor injection of hematoporphyrin derivative." 05/01/1984 - "Blood flow in transplantable bladder tumors treated with hematoporphyrin derivative and light." 03/01/1984 - "Giant cell formation in bladder tumor cells following hematoporphyrin derivative-sensitized photoirradiation." 03/01/1984 - "Cellular binding of hematoporphyrin derivative in human bladder cancer cell lines: KK-47."
4.	Atherosclerotic Plaque (Atheroma) 01/01/1989 - "The efficacy of 111In-labeled hematoporphyrin derivative (HPD) in localizing and detecting atheromas had been investigated with 10 atherogenic New Zealand white rabbits. " 12/01/1986 - "Uptake of hematoporphyrin derivative by atheromatous plaques: studies in human in vitro and rabbit in vivo." 01/01/1989 - "Scintigraphic detection of atherosclerotic plaques in rabbits with 111In-labeled hematoporphyrin derivative." 12/01/1986 - "In five patients undergoing surgical vascular procedures, specimens containing atheromatous plaques were removed and immediately incubated in autologous oxygenated blood at 37 degrees C with hematoporphyrin derivative at a clinically relevant concentration for 2 hours. " 12/01/1986 - "Hematoporphyrin derivative, a photosensitive material used to identify and treat neoplastic tissue in humans, has been found to localize in atheromatous plaques in animals and has recently been found in postmortem human atherosclerotic plaques. "
5.	Lung Neoplasms (Lung Cancer) 01/01/1983 - "Hematoporphyrin derivative in the diagnosis and treatment of lung cancer." 12/01/1982 - "Hematoporphyrin derivative in the detection and localization of radiographically occult lung cancer." 10/20/1986 - "[Evaluation of the combined procedure of Hp-D (hematoporphyrin derivative) phototherapy and radiation therapy in advanced lung cancer]." 07/25/1986 - "[Indication and evaluation of effectiveness of the HpD (hematoporphyrin-derivative) phototherapy in lung cancer]." 06/01/1985 - "Early detection of lung cancer by means of hematoporphyrin derivative fluorescence and laser photoradiation."

Related Drugs and Biologics

1.	Dihematoporphyrin Ether (Porfimer Sodium)
2.	1-phenyl-3,3-dimethyltriazene (PDT)
3.	Photosensitizing Agents (Photosensitizers)
4.	Argon
5.	temoporfin
6.	Glutathione Peroxidase
7.	Hematoporphyrins
8.	Porphyrins
9.	chlorin
10.	Superoxides (Superoxide)

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Lasers (Laser)
3.	Dye Lasers
4.	Phototherapy (Light Therapy)
5.	Aftercare (After-Treatment)