Photosensitizing Agents (Photosensitizers)

Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.

Also Known As:

Networked: 894 relevant articles (60 outcomes, 80 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hamblin, Michael R: 18 articles (08/2015 - 06/2004)
2.	Pandey, Ravindra K: 16 articles (01/2013 - 01/2004)
3.	Chen, Yihui: 11 articles (01/2013 - 01/2004)
4.	Morgan, Janet: 9 articles (10/2014 - 09/2005)
5.	van Lier, Johan E: 8 articles (09/2015 - 01/2005)
6.	Mironov, A F: 8 articles (06/2015 - 03/2001)
7.	Olivo, Malini: 8 articles (02/2015 - 01/2002)
8.	Berg, Kristian: 8 articles (01/2014 - 03/2002)
9.	Hasan, Tayyaba: 7 articles (12/2012 - 06/2004)
10.	Choyke, Peter L: 6 articles (08/2015 - 01/2014)

Related Diseases

1.	Neoplasms (Cancer) 09/27/2011 - "Owing to the significantly enhanced intracellular trafficking of photosensitizers, our GO-PEG-Ce6 complex offers a remarkably improved cancer cell photodynamic destruction effect compared to free Ce6. " 01/01/2012 - "Photosensitizers gathering in mitochondria (like porphyrin derivatives used in this work) are more effective in tumor cell destruction. " 10/06/2005 - "Our present work demonstrates the utility of the first 124I-labeled photosensitizer as a "multimodality agent", which could further be improved by using more tumor-avid and/or target-specific photosensitizers." 05/01/1993 - "Laboratory work to better understand the mechanism of action of HpD also continues, as well as investigations into alternative photosensitizers with improved tumor localization, less cutaneous photosensitivity, and absorption peaks at deeper penetrating wavelengths of light. " 05/01/1988 - "Laboratory work to better understand HpD also continues, as well as investigations into alternative photosensitizers with improved tumor localization, less cutaneous photosensitivity, and absorption peaks at deeper penetrating wavelengths of light. "
2.	Carcinoma (Carcinomatosis) 03/01/1990 - "Verdins have been shown to be effective photosensitizers in a urothelial carcinoma model in rats. " 01/10/2011 - "Moreover, because two identical microstructures on a single chip were performed, the microchip can be used for examination simultaneously various cell lines (carcinoma and normal) or various photosensitizers." 03/07/2010 - "The mono- and di-substituted photosensitizers bearing one or two PEG linkers and up to three peptide sequences were found to be the most phototoxic toward human carcinoma HEp2 cells, while the tetra-NLS conjugates symmetrically substituted around the porphyrin ring accumulated the least within cells and were non-phototoxic. " 12/01/2002 - "The characteristic fluorescence decay times and spectroscopic features of the sensitizer aggregates measured in aqueous solution also could be observed in A431 human endothelial carcinoma cells administered with these photosensitizers. " 04/01/1999 - "Photodynamically induced effects in colon carcinoma cells (WiDr) by endogenous photosensitizers generated by incubation with 5-aminolaevulinic acid."
3.	Wounds and Injuries (Trauma) 03/01/2012 - "The studies indicated that use of various photosensitizers combined with laser irradiation led to improved wound outcomes. " 01/01/2013 - "Excessive accumulation of photosensitizers in inflamed areas, as occasionally found at chronic wounds and tumors due to inflammatory processes, leads to false-positive results in FD. " 06/01/2005 - "In the present study, anastomotic vessels and their patency were evaluated in two primate CNV laser-trauma models after PDT, by using two novel photosensitizers. " 01/01/2012 - "On the other hand, by interaction with non-DNA chromophores as endogenous photosensitizers, UVA induces formation of reactive oxygen species (ROS), which play a pivotal role as mediators of UVA-induced injuries in human skin. " 11/01/1997 - "The authors used a pigmented rabbit model to investigate two photosensitizers, tin ethyl etiopurpurin (SnET2) and tin octaethyl benzochlorin (BNZ 203), to determine their potential for creating ciliary body injuries during photodynamic therapy (PDT). "
4.	Necrosis 10/01/2007 - "Recent developments in photosensitizers and light delivery systems have substantially reduced treatment times and residual photosensitivity, while increasing the achievable depth of necrosis. " 08/01/2000 - "In the plasma membrane, a target for various photosensitizers, rescue responses, apoptosis and necrosis is initiated. " 06/01/1995 - "They are suitable models mimicking specific situations occurring in vivo and they allow study of the influence of physicochemical, photobiological and biochemical factors on the uptake of photosensitizers by tissues, their mechanisms of action and the subsequent photoinduced tumor necrosis. " 06/01/2003 - "Despite the age-old belief that most anti-cancer agents kill tumor cells by necrosis, recent findings have demonstrated that photosensitizers could also kill tumor cells by triggering genetically programmed series of events termed apoptosis. " 06/01/1990 - "The selective retention of photosensitizers by dimethylhydrazine-induced colonic tumors over adjacent normal tissue is small (2:1, tumor to normal), making the possibility of producing selective tumor necrosis with total sparing of normal tissue difficult. "
5.	Neoplasm Metastasis (Metastasis) 01/01/1985 - "The 46 post-operative skin metastases of breast carcinoma in 15 women were irradiated with no photosensitizers used. " 09/01/2007 - "The aim of this study was to test two photosensitizers, benzoporphyrin-derivative monoacid ring A (BPD-MA) and by 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX), for their potential use to treat bony metastases. " 12/01/2008 - "Taking into consideration substantial prevalence in clinical practice of drug-resistant tumors and angiogenesis-dependent character of metastasis process, further study and application of photosensitizers, conjugated with antibodies to VEGF, may help to improve the clinical outcomes."

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	Dihematoporphyrin Ether (Porfimer Sodium)
3.	hypericin
4.	Hematoporphyrin Derivative
5.	protoporphyrin IX
6.	temoporfin
7.	Liposomes (Liposome)
8.	chlorin
9.	Antibodies
10.	Micelles

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Lasers (Laser)
3.	Drug Therapy (Chemotherapy)
4.	Optical Fibers
5.	Radiotherapy