Annexin A4

Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.

Also Known As:

Networked: 63 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Trapasso, Francesco: 3 articles (01/2021 - 01/2013)
2.	Kimura, Tadashi: 3 articles (01/2015 - 11/2009)
3.	Ueda, Yutaka: 3 articles (01/2015 - 11/2009)
4.	Naka, Tetsuji: 3 articles (04/2014 - 11/2009)
5.	Serada, Satoshi: 3 articles (04/2014 - 11/2009)
6.	Campiglia, Pietro: 2 articles (01/2021 - 05/2016)
7.	Boye, Theresa Louise: 2 articles (01/2020 - 11/2017)
8.	Nylandsted, Jesper: 2 articles (01/2020 - 11/2017)
9.	Simonsen, Adam Cohen: 2 articles (01/2020 - 11/2017)
10.	Nagano, Kazuya: 2 articles (01/2018 - 04/2012)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2012 - "Up-regulated HSPB1 and Annexin A4 may play many important roles in the pathogenesis of colorectal cancer." 01/01/2021 - "Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma." 10/01/2008 - "Annexin A2, annexin A4 and VDAC appear as potential markers of interest for colorectal cancer diagnosis and, presumably, therapy. " 01/01/2012 - "Compared with normal colorectal mucosa, protein abnormal expression of 65 spots varying more than 1.5 times were found in 2-DE gels from colorectal cancer samples (P<0.05); forty-two proteins were up-regulated and 23 were down-regulated; twelve protein spots were identified using mass spectrometry, of which 8 were up-regulated, including HSPB1 and Annexin A4, while 4 were down-regulated, the results being consistent with Western blot findings. " 08/01/2007 - "The results revealed that Tiam1 transfection in colorectal cancer cells could upregulate the expression of Fascin-1, heat shock protein 27 (HSP27), high-mobility group box 1 (HMGB1), glutathione S-transferase omega 1 (GSTO1) and downregulate the expression of annexin IV. These differentially expressed proteins may be directly or indirectly regulated by Tiam1 and be helpful in studying mechanisms that lead to the function of Tiam1. "
2.	Neoplasms (Cancer) 05/01/2023 - "HOXD-AS1 may upregulate Annexin A4 by sponging miR-203a-5p in OSCC to promote cancer cell invasion and migration." 01/01/2019 - "Considering that annexin A4 (ANXA4) enhances tumor invasion, we aimed to explore the functional role of ANXA4 in trophoblast cells and to examine the underlying mechanism. " 01/01/2016 - "The role of annexin A4 in cancer." 07/20/2015 - "Annexin A4 and cancer." 06/01/2013 - "The levels of annexin A4 transcripts were higher in 14 chemoresistant tumors than those in 26 chemosensitive tumors (P = .013). "
3.	Carcinoma (Carcinomatosis) 06/01/2013 - "This study showed that overexpression and nuclear localization of annexin A4 are related to chemoresistance and poor survival in patients with serous papillary ovarian carcinomas. " 06/01/2013 - "The aim of this study was to examine the expression and cellular localization of annexin A4 in serous ovarian carcinomas. " 09/01/2016 - "We adopted immunohistochemical and western blot to detect annexin A4 expression in TNBC and para-carcinoma tissues, and to explore the relationship between abnormal expression of annexin A4 and clinicopathological features of TNBC patients. " 06/01/2013 - "We evaluated the expression of annexin A4 with real-time polymerase chain reaction in 40 ovarian serous carcinoma tissues. " 10/01/2011 - "Finally, we found reduced expression of annexin IV coincident with decreased NME1 expression in a panel of different carcinoma cell lines. "
4.	Neoplasm Metastasis (Metastasis) 07/12/2019 - "Overall, reactivation of the miR-203/annexin A4 axis may represent a new strategy for overcoming metastasis of GC." 07/01/2016 - "Cox proportional hazards regression analysis revealed that annexin A4 was an independent prognostic predictor for both early recurrence/metastasis (HR = 1.519, p = 0.032) and overall survival (HR = 1.827, p = 0.009) after surgical resection. " 01/01/2021 - "Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma." 12/08/2017 - "The interaction between annexin A4 and NF-kB p50 promoted cell proliferation, adhesion, invasion, metastasis ability and autophagy, and inhibits apoptosis, Lewis y enhanced this interaction. " 01/01/2015 - "The results were validated using a further independent set of specimens and this showed a significant association between the staining score for annexin 4 and HPA and the time to metastasis; independently (annexin A4: Chi square 11.45, P = 0.0007; HPA: Chi square 9.065, P = 0.0026) and in combination (annexin 4 and HPA combined: Chi square 13.47; P = 0.0002). "
5.	Ovarian Neoplasms (Ovarian Cancer) 09/01/2020 - "Annexin A4 (ANXA4) is one of the annexin family with high expressions found in gastric, liver, lung, colorectal and ovarian cancers. " 12/08/2017 - "Annexin A4 and Lewis y antigen expression in various subtypes of ovarian cancer tissues was detected by immunohistochemistry, and the relation between their expression was examined. " 06/01/2013 - "Annexin A4 study in ovarian cancer has been primarily focused on clear cell carcinoma, which exhibits strong resistance to chemotherapy. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	HSP27 Heat-Shock Proteins
3.	HMGB1 Protein (HMG1)
4.	Glutathione Transferase (Glutathione S-Transferase)
5.	Annexins
6.	Carrier Proteins (Binding Protein)
7.	Annexin A2 (Annexin II)
8.	Phospholipids (Phosphatides)
9.	Cathepsin D
10.	Calcium

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)