HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Etodolac (Lodine)

A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ankylosing SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).

Also Known As:

Lodine; AY-24,236; AY-24236; Etodolac, (+-)-Isomer; Etodolac, (-)-Isomer; Etodolac, (S)-Isomer; Etodolac, Monosodium Salt; Etodolac, Monosodium Salt, (+-) Isomer; Etodolac, Monosodium Salt, (S)-Isomer; Etodolic Acid; Ramodar; Ultradol; AY 24,236; AY 24236; AY24,236; AY24236; Acid, Etodolic; Pyrano(3,4-b)indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-

Networked: 270 relevant articles (50 outcomes, 90 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Indoles: 95
    - Indoleacetic Acids: 268
      - Etodolac: 270
        5-hydroxyetodolac
        6-hydroxyetodolac glucuronide
        etodolac glucuronide
- Heterocyclic Acids
  - Indoleacetic Acids: 268
    - Etodolac: 270

Experts

1.	Inoue, Naoki: 5 articles (07/2012 - 06/2003)
2.	Carson, Dennis A: 4 articles (10/2015 - 01/2004)
3.	Kato, Rina: 4 articles (12/2013 - 05/2005)
4.	Udagawa, Yasuhiro: 4 articles (12/2013 - 05/2005)
5.	Hasegawa, Kiyoshi: 4 articles (12/2013 - 05/2005)
6.	Kyoi, Takashi: 4 articles (07/2012 - 04/2009)
7.	Ito, Sunao: 4 articles (07/2012 - 04/2009)
8.	Nogawa, Masaki: 4 articles (07/2012 - 04/2009)
9.	Tajima, Koyuki: 4 articles (07/2012 - 04/2009)
10.	Benish, Marganit: 4 articles (04/2011 - 03/2010)

Related Diseases

1.	Pain (Aches) 01/01/1983 - "At the end of the study, patients treated with etodolac showed significant improvement from baseline values in seven of ten clinical variables, namely, painful joints, swollen joints, articular index, pain intensity, morning stiffness, and investigator's and patient's overall assessments. " 01/01/1991 - "In addition, the etodolac-treated patients had significant improvement according to the patients' and physician's global evaluations, pain intensity, number of swollen joints, and grip strength. " 05/01/2000 - "It was concluded that gait performances improved because of less hip pain and thus a greater range of motion after etodolac intake." 01/01/1990 - "Data are presented from four representative studies that showed the analgesic activity of etodolac in postsurgical pain models. " 01/01/2009 - " proportion of participants with at least 50% pain relief was 41% with 100 mg and 44% with 200 mg. Remedication was needed by about 60% with etodolac 200 mg or 400 mg over 6 to 8 hours, compared with almost 80% with placebo.Adverse"
2.	Osteoarthritis 01/01/1989 - "The efficacy of etodolac (600 mg/day) and placebo were compared in a 4-week double-blind, parallel-group study involving 104 patients with osteoarthritis of the knee and 106 with osteoarthritis of the hip. " 01/15/1999 - "Etodolac administration for 8 days improved ground reaction forces in dogs with osteoarthritis of the hip joint. " 01/15/1999 - "To assess the efficacy of etodolac in improving hind limb function in dogs with osteoarthritis of the hip joint. " 01/15/1999 - "Efficacy of etodolac for the treatment of osteoarthritis of the hip joints in dogs." 01/01/1993 - "Worldwide experience with the conventional formulation of etodolac (300 mg b.i.d.) was reviewed in 12 randomized, double-blind, parallel-group studies in patients with osteoarthritis (OA) of the hip or knee. "
3.	Rheumatoid Arthritis 02/01/1997 - "Short and longterm safety and efficacy of etodolac in a wide range of dosages in patients with rheumatoid arthritis (RA) are summarized. " 02/01/1997 - "Etodolac Study 326 Rheumatoid Arthritis Investigators Group." 02/01/1997 - "Low dose etodolac in rheumatoid arthritis: a review of early studies." 01/01/1993 - "One study included 174 patients with rheumatoid arthritis (RA): 58 received etodolac SR 400 mg once daily (q.d.), 59 received etodolac SR 600 mg q.d., and 57 received etodolac 200 mg twice daily (b.i.d.). " 01/01/1993 - "A meta-analysis was done with the data from two studies that provided the first efficacy and safety results for the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis (RA). "
4.	Postoperative Pain 01/01/2009 - "To assess the analgesic efficacy of etodolac in single oral doses for moderate and severe postoperative pain. " 01/01/2009 - "Randomised, double blind, placebo-controlled trials of single dose orally administered etodolac (any formulation) in adults with moderate to severe acute postoperative pain. " 08/01/1999 - "This double-masked, parallel-group, randomized study compared the analgesic efficacy and tolerability of a single investigational 1200-mg dose of extended-release etodolac with those of a single 400-mg dose of extended-release etodolac and twice-daily doses of conventional etodolac 200 and 400 mg and placebo given 8 hours apart in 237 patients with moderate or severe postoperative pain following surgical removal of > or = 2 impacted third molars. " 01/01/2009 - "Single dose oral etodolac for acute postoperative pain in adults." 01/01/2004 - "Oral etodolac, a COX-2 inhibitor, reduces postoperative pain immediately after fast-track cardiac surgery."
5.	Hyperalgesia 06/04/2004 - "Etodolac alleviated heat-evoked hyperalgesia in the CCI rats and the increase in number of TRAP-positive multinucleated osteoclasts on the CCI-side was abrogated, however, it did not inhibit the decrease of BMC and BMD on the CCI-side. " 06/04/2004 - "The aim of the present study was to determine whether etodolac can alleviate heat-evoked hyperalgesia and investigate its possible protective effects on osteoporosis induced by chronic constriction injury (CCI) in rats. " 01/01/2011 - "We previously reported that etodolac attenuates allodynia in a mouse model of neuropathic pain by a COX-2-independent mechanism [N. " 04/01/2009 - "Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain." 04/01/2009 - "These findings suggest that the mechanisms of inhibition of mechanical allodynia by etodolac and pregabalin are different and demonstrate that in contrast to other COX inhibitors, etodolac is effective against mechanical allodynia in a mouse neuropathic pain model."

Related Drugs and Biologics

1.	Naproxen (Naprosyn)
2.	Piroxicam (Feldene)
3.	Diclofenac (SR 38)
4.	Etodolac (Lodine)
5.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
6.	Acetaminophen (Paracetamol)
7.	Aspirin (Acetylsalicylic Acid)
8.	3- (cyclopropylmethoxy)- 4- (4- methylsulfonylphenyl)- 5,5- dimethylfuranone
9.	Indomethacin (Indometacin)
10.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)

Related Therapies and Procedures

1.	Oral Surgery (Maxillofacial Surgery)
2.	Oral Administration
3.	Thoracotomy
4.	Obstetrical Anesthesia
5.	Vasectomy (Vas Occlusion)