Siderophores

05/08/2009 - "The host molecule lipocalin-2 exploits this by sequestering bacterial siderophores as a mechanism of protection against infection. "
10/01/2014 - "Recent studies also indicate the high potential of siderophores and its biosynthetic pathway to improve diagnosis and therapy of fungal infections."
08/01/2015 - "The roles of these siderophores in hvKP infection have not been optimally defined. "
06/01/2015 - "Uropathogenic Escherichia coli secrete siderophores during human infections. "
06/01/2015 - "The combination of siderophores produced by a pathogen can enable inter-bacterial competition, modulate host cellular pathways, and determine the bacterial "replicative niche" during infection. "

02/01/2013 - "Finally, immunizations with FhuD2 alone or FhuD2 formulated with hydroxamate siderophores were equally protective in a murine staphylococcal infection model, confirming the suitability and efficacy of apo-FhuD2 as a protective antigen, and suggesting that other class III SBPs might also be exploited as vaccine candidates."

01/01/2015 - "When subjected to iron starvation conditions, Pseudomonas bacteria synthesize pyoverdines, their primary siderophores, to acquire iron from the extracellular medium. "
06/01/2001 - "Fluorescent pseudomonads produce yellow-green siderophores when grown under conditions of iron starvation. "
02/01/2009 - "Our studies, and those of others, demonstrate that siderophores and analogs can be used for iron transport-mediated drug delivery ("Trojan Horse" antibiotics) and induction of iron limitation/starvation (Development of new agents to block iron assimilation). "
01/01/2014 - "Two transcription factors, the GATA-factor SreA and the bZip-factor HapX oppositely monitor iron homeostasis with HapX activating iron acquisition pathways (e.g., siderophores) and shutting down iron consumptive pathways (and SreA) during iron starvation conditions whereas SreA negatively regulates HapX and corresponding pathways during iron sufficiency. "
01/01/2013 - "Pseudomonads are characterized by the secretion of siderophores (e.g., pyoverdine), low-molecular weight compounds that chelate Fe3+ during iron starvation. "

03/01/2008 - "Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores."
03/01/2008 - "Taken together, this study reveals what we believe to be a previously unrecognized role of bacterial siderophores for hypoxia-independent activation of HIF-1 during infection with human pathogenic bacteria."
09/01/2014 - "Bacterial siderophores that evade or overwhelm lipocalin 2 induce hypoxia inducible factor 1α and proinflammatory cytokine secretion in cultured respiratory epithelial cells."

01/01/1999 - "Our study suggests that microbial siderophores may represent new-potential therapeutic molecules for the treatment of destructive inflammatory diseases involving excess MMP-2 activity, such as periodontitis."