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Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)

Subscribe to New Research on Glycosylphosphatidylinositols

Compounds containing carbohydrate or glycosyl groups linked to phosphatidylinositols. They anchor GPI-LINKED PROTEINS or polysaccharides to cell membranes.

Also Known As:

Glycosyl-Phosphatidylinositol; Glycosylphosphatidylinositol; Gly-PtdIns; Glycoinositol Phospholipid Membrane Anchor; Glycosyl-Phosphatidylinositol Membrane Protein Anchors; Glycosylated Phosphatidylinositols; Glycosylphosphatidylinositol Linkage; PI-Glycan; Anchors, GPI Membrane; Anchors, Glycosylphosphatidylinositol; Glycan, Phosphatidylinositol; Glycosyl Phosphatidylinositol; Glycosyl Phosphatidylinositol Membrane Protein Anchors; Linkage, Glycosylphosphatidylinositol; Membrane Anchors, GPI; PI Glycan; Phosphatidylinositols, Glycosylated; GPI Membrane Anchors; Glycosylphosphatidylinositol Anchors; Phosphatidylinositol Glycan

Networked: 556 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gowda, D Channe: 16 articles (02/2012 - 09/2002)
2.	Kinoshita, Taroh: 15 articles (12/2015 - 04/2002)
3.	Murakami, Yoshiko: 13 articles (12/2015 - 12/2002)
4.	Brodsky, Robert A: 9 articles (06/2015 - 05/2005)
5.	Krishnegowda, Gowdahalli: 8 articles (06/2009 - 07/2003)
6.	Seeberger, Peter H: 7 articles (01/2016 - 11/2002)
7.	Luzzatto, Lucio: 7 articles (04/2013 - 09/2002)
8.	Ferguson, Michael A J: 6 articles (03/2012 - 12/2002)
9.	Selvaraj, Periasamy: 5 articles (01/2016 - 01/2004)
10.	Kamena, Faustin: 5 articles (01/2016 - 04/2008)

Related Diseases

1.	Malaria 07/01/2003 - "Immune responses directed at glycosylphosphatidylinositol (GPI) anchors of Plasmodium falciparum may offer protection against symptomatic malaria. " 03/01/1996 - "In this study we demonstrate that glycosylphosphatidylinositol (GPI) of malaria parasite origin directly increases cell adhesion molecule expression in purified HUVECs in a dose- and time-dependent manner, resulting in a marked increase in parasite and leukocyte cytoadherence to these target cells. " 01/01/2016 - "Human C1-Inhibitor Suppresses Malaria Parasite Invasion and Cytoadhesion via Binding to Parasite Glycosylphosphatidylinositol and Host Cell Receptors." 12/01/2013 - "The key protozoan parasite Plasmodium falciparum causes malaria through glycosylphosphatidylinositols (GPIs), which induce the host immune response mainly via TLR2 signalling. " 12/01/2012 - "Merozoite surface protein 2 (MSP2) is an abundant glycosylphosphatidylinositol (GPI)-anchored protein of Plasmodium falciparum, which is a potential component of a malaria vaccine. "
2.	Neoplasms (Cancer) 11/01/2002 - "To strengthen the efficacy of the prodrug-activating system, the enzyme has been engineered to be secreted or glycosylphosphatidylinositol (GPI) anchored to the extracellular membrane of tumor cells, resulting in an enhanced bystander effect by facilitating diffusion of the active drug through extracellular, rather than intracellular, activation. " 01/01/2014 - "Generation of a monoclonal antibody against the glycosylphosphatidylinositol-linked protein Rae-1 using genetically engineered tumor cells." 10/07/2011 - "Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion." 06/01/2011 - "Expression of CD24, a glycosyl phosphatidylinositol (GPI)-linked sialoglycoprotein and cancer stem cell marker, is associated with metastatic progression in multiple cancer types, yet the role of CD24 in this process remains unclear. " 10/01/2005 - "[Glycosylphosphatidylinositol-anchored protein and cancer]."
3.	Infection 08/01/2002 - "Recent studies show that glycosylphosphatidylinositol (GPI) functions as the dominant parasite toxin in the context of infection. " 10/01/2009 - "Here we establish that despite its type II transmembrane topology and carboxy-terminal glycosylphosphatidylinositol (GPI) anchor, BST2 represents a bona fide target of K5 that is downregulated during primary infection by and reactivation of KSHV. " 04/01/2008 - "The Candida albicans gpi7/gpi7 null mutant strain (Deltagpi7), which is affected in glycosylphosphatidylinositol (GPI) anchor biosynthesis, showed a reduced virulence following systemic infection of C57BL/6 mice. " 05/01/2005 - "falciparum glycosylphosphatidylinositols (PfGPIs) can induce NOS expression in immune and endothelial cells and are sufficient to reproduce the major effects of parasite infection. " 03/01/2004 - "Furthermore, engineered CEACAMs appended to glycosylphosphatidylinositol anchors partitioned with TX-100-resistant lipid rafts, but cells bearing these raft-associated CEACAMs were not hypersensitive to MHV infection. "
4.	Breast Neoplasms (Breast Cancer) 10/01/2011 - "Cluster of differentiation 24 (CD24) is a small glycosylphosphatidylinositol-linked cell surface molecule that is expressed in a variety of human carcinomas, including breast cancer. " 06/01/2015 - "We converted the breast cancer HER-2 antigen to a glycosylphosphatidylinositol (GPI)-anchored form and incorporated GPI-HER-2 onto VLPs by a rapid protein transfer process. " 01/01/2013 - "PI-PLC treatment released both TFPIα and TFPIβ from the breast cancer cell membrane and increased TF activity on the cell surface, showing TF-FVIIa inhibitory activity of the glycosylphosphatidylinositol- (GPI-) anchored TFPI. " 05/15/2006 - "We have investigated the involvement of MT4-MMP, a glycosylphosphatidylinositol-anchored protease, in breast cancer progression. " 05/07/2013 - "In this study, we have evaluated the efficacy of 4TO7, a highly tumorigenic murine mammary tumor cell line, expressing glycosyl phosphatidylinositol (GPI)-anchored form of cytokine molecules alone or in combination with the costimulatory molecule B7-1 as a model for potential cell or membrane-based breast cancer vaccines. "
5.	Urinary Bladder Neoplasms (Bladder Cancer) 05/01/2010 - "In order to improve the efficacy of TEXs, we investigated whether exosomes derived from glycosyl-phosphatidylinositol-anchored interleukin 2 (GPI-IL-2) gene-modified bladder cancer cells can increase the antitumor effects. " 01/01/2008 - "To investigate cell division cycle 91-like 1 (CDC91L1; also called phosphatidylinositol glycan class U, PIG-U) expression in bladder cancer at both the mRNA and protein levels, and to study its clinical and prognostic significance, as CDC91L1 was recently identified as a new oncogene in human bladder cancer and its role in the biological behaviour of bladder cancer is largely unknown. " 01/01/2010 - "Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI) anchored protein expressed not only in prostate but also in pancreas and bladder cancer as shown by immunohistochemistry and mRNA analysis. "

Related Drugs and Biologics

1.	CD80 Antigens
2.	Vaccines
3.	Dexamethasone (Maxidex)
4.	Interleukin-2 (IL2)
5.	Protein Kinases (Protein Kinase)
6.	Insulin (Novolin)
7.	PPAR gamma
8.	NF-kappa B (NF-kB)
9.	Hormones
10.	rosiglitazone (Avandia)

Related Therapies and Procedures

1.	Immunotherapy
2.	Platelet Transfusion (Blood Platelet Transfusions)
3.	Erythrocyte Transfusion
4.	Intravenous Injections