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Technetium Tc 99m Sestamibi (Cardiolite)

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A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.

Also Known As:

Cardiolite; Du Pont Brand of Technetium Tc 99m Sestamibi; Tc-99m-Methoxy-2-isobutylisonitrile; Technetium Tc 99m 2-Methoxy-2-methylpropylisonitrile; Technetium Tc 99m Sestamibi Chloride; Technetium-99m-Hexamibi; Technetium-99m-Sestamibi; 99mTc Hexamibi; 99mTc Sestamibi; Tc 99m Methoxy 2 isobutylisonitrile; Technetium 99m Hexamibi; Technetium 99m Sestamibi; Technetium Tc 99m 2 Methoxy 2 methylpropylisonitrile; 99mTc-Hexamibi; 99mTc-Sestamibi; Tc MIBI; Technetium(1+)-99Tc, hexakis(1-isocyano-2-methoxy-2-methylpropane)-, (OC-6-11)-

Networked: 730 relevant articles (28 outcomes, 139 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Rubello, D: 6 articles (09/2008 - 07/2000)
2.	Kao, C H: 6 articles (07/2001 - 09/2000)
3.	Ho, Y J: 6 articles (07/2001 - 09/2000)
4.	Tsai, S C: 6 articles (07/2001 - 09/2000)
5.	Mariani, Giuliano: 5 articles (10/2013 - 08/2003)
6.	Rubello, Domenico: 5 articles (10/2011 - 02/2005)
7.	Cuocolo, Alberto: 5 articles (12/2009 - 11/2004)
8.	Petretta, Mario: 5 articles (12/2009 - 11/2004)
9.	Pelizzo, M R: 5 articles (09/2007 - 07/2000)
10.	Assadi, Majid: 4 articles (01/2014 - 04/2010)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/01/2014 - "Primary accessory breast cancer is extremely rare, and the diagnostic efficacy of Tc-MIBI breast-specific γ imaging (BSGI) has not been reported elsewhere. " 03/01/2003 - "It can be concluded that there are indications that scintimammography with Tc-MIBI is superior to that with Tc-anti-CEA Fab' when these tests are used as screening tests for breast cancer. " 05/01/1996 - "Our study was aimed at investigating the efficacy of scintigraphy with 99mTc-Sestamibi (MIBI) as a support to mammography and US in the diagnosis and staging of breast cancer. " 08/01/2007 - "The aim of this study was to asses the accuracy of 99mTc-sestamibi scintimammography in patients with suspected recurrent breast cancer in the breast or loco regional tissues. " 10/01/2004 - "The aim of this study was to assess the utility of 99mTc-sestamibi scintimammography (SM) in patients with suspected primary or recurrent breast cancer. "
2.	Primary Hyperparathyroidism 06/01/1997 - "Technetium 99m sestamibi was recently introduced for the preoperative localization of abnormal parathyroid glands in patients with primary hyperparathyroidism with promising results. " 05/01/2005 - "This study was planned to investigate the efficacy of either 99mTc-sestamibi scan or ultrasonography in predicting the operative treatment in patients with primary hyperparathyroidism (PHPT). " 03/01/2002 - "A prospective study was performed to evaluate the efficacy of technetium-99m-sestamibi and technetium-99m-pertechnetate subtraction scanning and US for imaging parathyroid glands in primary hyperparathyroidism. " 01/01/2013 - "The objective of this study was to assess the utility of ultrasonography (US) and technetium-99m-sestamibi (MIBI) scans in locating ectopic parathyroid glands in previously unexplored patients who presented with primary hyperparathyroidism. " 02/01/2005 - "Radioguided surgery of primary hyperparathyroidism using the low-dose 99mTc-sestamibi protocol: multiinstitutional experience from the Italian Study Group on Radioguided Surgery and Immunoscintigraphy (GISCRIS)."
3.	Neoplasms (Cancer) 06/01/1999 - "Many clinical studies from different institutions and trials including a variety of malignancies indicate that both tumor uptake and clearance of 99mTc-Sestamibi are correlated with Pgp expression and may be used for the phenotypic assessment of multidrug resistance. " 09/01/1996 - "Additional 99mTc-sestamibi SPECT imaging of the primary tumor and superimposing of both studies excluded osseous tumor spread and less extensive surgery was performed. " 04/01/2015 - "A large number of thyroid cancers take up 99mTc-sestamibi (MIBI). " 07/01/2013 - "Technetium-99m-sestamibi (MIBI) is a radiopharmaceutical that has well-known tumor-seeking properties. " 06/01/2011 - "Positive accumulation of (99m) Tc-MIBI in tumors was observed in 76 patients (88.4%). "
4.	Parathyroid Neoplasms (Parathyroid Neoplasm) 06/01/1996 - "The aim of the study was to assess the efficacy of parathyroid imaging with 99m Tc-MIBI for preoperative localization of parathyroid adenomas and to compare that method with the high-resolution ultrasonography. " 02/01/2008 - "Forty patients with PHPT, positive to preoperative localization studies (ultrasonography evaluation and (99)Tc-MIBI scan) for a single parathyroid adenoma, were randomly allotted into two groups. " 04/01/1996 - "Preoperative localization of parathyroid adenoma by technetium Tc 99m sestamibi delayed washing-out scanning and high-resolution ultrasound was compared with a historical institutional experience of surgical intervention without preliminary localization studies. " 04/01/2015 - "Parathyroid adenoma localization with 99mTc-sestamibi SPECT/CT: a meta-analysis." 04/01/2014 - "In addition, we discuss the use of scanning with technetium Tc 99m sestamibi, the PTH assay, and cervical ultrasonography in the workup of a parathyroid adenoma. "
5.	Carcinoma (Carcinomatosis) 10/01/1995 - "The aim of this study was to evaluate the usefulness of scintimammography using 99mTc-sestamibi as a complementary technique to mammography for the detection of breast carcinoma to improve mammography's sensitivity and specificity. " 07/01/2003 - "[Examination of regional limph nodes in penile carcinoma by 99M Tc-MIBI scintigraphy]." 05/01/2003 - "99mTc-sestamibi uptake and histological malignancy grade in invasive breast carcinoma." 09/01/2000 - "Technetium-99m tetrofosmin (Tc-TF) a thallium-201 (Tl-201) and technetium-99m methoxy-isobutyl-isonitrile (Tc-MIBI) competitor, being used as a new radiopharmaceuticalfor myocardial imaging was assessed to understand its value in detecting esophageal carcinoma (Eso-Ca). " 04/01/2000 - "99m Tc MiBi has emerged as a new imaging technique for primary breast carcinomas. "

Related Drugs and Biologics

1.	technetium Tc 99m 1,2- bis(bis(2- ethoxyethyl)phosphino)ethane (Myoview)
2.	P-Glycoprotein
3.	Adenosine
4.	Technetium (Technetium 99m)
5.	Hormones
6.	technetium 99m (N- (dithiocarbamato)- 2- aminomethyl- 15- crown- 5)(N,N- bis(2- (3- ethoxypropyl)phosphino)ethyl)methoxyethylamine
7.	hydroxide ion
8.	Nisoldipine
9.	Methylene Blue (Methylthioninium Chloride)
10.	Complement System Proteins (Complement)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Enzyme Replacement Therapy
4.	Parathyroidectomy
5.	Aftercare (After-Treatment)