Leukemic Infiltration

A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukemia show various degrees of infiltration, depending upon the type of leukemia. The degree of infiltration may vary from site to site. The liver and spleen are common sites of infiltration, the greatest appearing in myelocytic leukemia, but infiltration is seen also in the granulocytic and lymphocytic types. The kidney is also a common site and of the gastrointestinal system, the stomach and ileum are commonly involved. In lymphocytic leukemia the skin is often infiltrated. The central nervous system too is a common site.

Also Known As:

Networked: 80 relevant articles (8 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Leukemia
2.	Lymphoma (Lymphomas)
3.	Cicatrix (Scar)
4.	Residual Neoplasm
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)

Experts

1.	Sata, Tetsutaro: 2 articles (01/2006 - 05/2003)
2.	Dewan, M Zahidunnabi: 2 articles (01/2006 - 05/2003)
3.	Ito, Mamoru: 2 articles (01/2006 - 05/2003)
4.	Yamamoto, Naoki: 2 articles (01/2006 - 05/2003)
5.	Kubuki, Yoko: 2 articles (01/2006 - 05/2003)
6.	Mori, Naoki: 2 articles (01/2006 - 05/2003)
7.	Terashima, Kazuo: 2 articles (01/2006 - 05/2003)
8.	Okayama, Akihiko: 2 articles (01/2006 - 05/2003)
9.	Perdomo, Tatiana: 1 article (01/2015)
10.	Valluri, Kartik: 1 article (01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Leukemic Infiltration:

1.	Interferon-alpha (Interferon Alfa)FDA Link 12/01/1997 - "The patient initially responded well to interferon alfa therapy and showed regression of skin lesions and diminished lymphocytosis, but 4 years later, she developed massive lymphadenopathy and leukemic infiltration of the breast. "
2.	Lorazepam (Ativan)FDA LinkGeneric 06/01/1987 - "Our hypothesis is that eradication of hepatic leukemic infiltration by ALL remission therapy resulted in an improvement in microsomal metabolism of antipyrine and lorazepam."
3.	Interleukin-2 (IL2)IBA 07/01/1993 - "These findings suggest that: (a) maximum GVL effect after BMT with ABM is concentrated in the early post-transplant period possibly because of minimal residual disease during this time; (b) an increase in the NK activity induced by IL-2 therapy may not predict for an improved GVL effect; and (c) for optimum GVL effect, BM with minimal leukemic infiltration should be activated with IL-2 before BMT."
4.	Hydroxyurea (Hydrea)FDA LinkGeneric 01/01/2002 - "This case demonstrates that hydroxyurea can be used effectively to decrease blast cell count and resolve leukemic infiltration of both lungs in patients with acute myeloblastic leukemia."
5.	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 07/01/1989 - "We investigated whether an indirect nuclear terminal deoxynucleotidyl transferase (TdT) immunofluorescence (IF) assay on single cells present in the cerebrospinal fluid (CSF) is more effective than conventional cytomorphology for early detection or exclusion of (minimal) meningeal leukemic infiltration in patients with a TdT+ malignancy. "
6.	Antipyrine (Phenazone)FDA Link 06/01/1987 - "Our hypothesis is that eradication of hepatic leukemic infiltration by ALL remission therapy resulted in an improvement in microsomal metabolism of antipyrine and lorazepam."
7.	Methotrexate (Mexate)FDA LinkGeneric 07/01/2002 - "The presumptive diagnosis of leukemic infiltration of the optic nerves was made, and urgent radiotherapy, intrathecal methotrexate, and intravenous daunorubicin were instituted. " 11/01/1979 - "Maintenance-therapy consisted of 6-mercaptopurine, cyclophosphamide and methotrexate i.v. Before treatment only 24% of patients showed normal EEG-findings, whereas 57% presented sly induced by leukemic infiltrations and partly due to the impaired clinical state. "
8.	Dacarbazine (DIC)FDA LinkGeneric 04/01/1989 - "Three months after admission, she died of DIC and pulmonary insufficiency due to leukemic infiltration." 12/31/1984 - "The in vivo bioassays of brains, and the histologic examinations of the livers of leukemic mice show that DM-COOK and DTIC prevent leukemic infiltration in these organs at dosages devoid of cytotoxic effects for peritoneal tumor cells. "
9.	Carbon MonoxideIBA 01/01/2014 - "Histologic analyses revealed that massive leukemic infiltrations were closely packed in dense sheets that effaced the normal architecture of spleen and thymus in mice transplanted with AML1/ETO + KRAS co-transduced cells. " 01/01/2015 - "Appendix pathology described leukemic infiltration with co-expression of myeloperoxidase and CD68, consistent with myeloid sarcoma of the appendix. "
10.	Alkaline PhosphataseIBA 01/01/1975 - "The juvenile type of chronic myelogenous leukemia (CML) is characterized by hemorrhagic diathesis, hepatosplenomegaly, generalized enlargement of lymph nodes, reduced erythro- and thrombopoiesis, leukemic infiltration of bone marrow, and decreased activity of leukocyte alkaline phosphatase. " 11/01/1983 - "[The effect of leukemic infiltration of the liver on levels of alkaline phosphatase in the serum, serum transaminases and serum protein]."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 09/01/1990 - "Although otologic involvement by leukemic infiltration was supposed to be unusual, increasing number of cases have been reported in recent years, probably due to the advance of chemotherapy, improved remission rate and longer survival of leukemic patients. " 01/01/2012 - "Five months later leukemic infiltration of the bone marrow was detected and systemic chemotherapy was reintroduced. " 11/01/1997 - "These patients were resistant to apoptosis, poor responsed to chemotherapy and associated with adverse prognostic features, such as high WBC counts, local leukemic infiltrations. " 03/01/1993 - "Although peripheral nervous system dysfunction in ALL is often attributed to leukemic infiltration or chemotherapy, a diligent search with electrophysiologic evaluation should be considered and may suggest alternative diagnoses." 01/01/1992 - "Bilateral wedge biopsy of the testes was performed in 16 boys at the end of chemotherapy and leukemic infiltration was shown in none of them. "
2.	Transplants (Transplant) 11/01/1978 - "Histologic study of eyes used as donor material for corneal transplant revealed one instance of massive leukemic infiltration with leukemic keratic precipitates on the fellow eye. " 07/01/2007 - "In all of the retrieved leukemic grafts, rat spermatogenesis was destroyed and only leukemic infiltration was detected. " 11/01/2007 - "Recruitment of activated T cells to host target tissues or sites of leukemic infiltration (graft-versus-leukemia [GVL]) is likely mediated by chemokine receptor-ligand interactions. " 07/01/1993 - "These findings suggest that: (a) maximum GVL effect after BMT with ABM is concentrated in the early post-transplant period possibly because of minimal residual disease during this time; (b) an increase in the NK activity induced by IL-2 therapy may not predict for an improved GVL effect; and (c) for optimum GVL effect, BM with minimal leukemic infiltration should be activated with IL-2 before BMT."
3.	Catheters 03/01/1993 - "During a second chemotherapy-induced complete remission, a subcutaneous nodule appeared at the scar of a recently removed Hickman catheter, which when biopsied revealed leukemic infiltration of the dermis and hypodermis. " 01/01/1987 - "We describe a patient with myelomonocytic leukemia who demonstrated striking leukemic infiltration in the scar of a recent Hickman catheter placement. "
4.	Radiotherapy 02/01/1999 - "Criteria for inclusion were 1) no evidence of intracranial leukemic infiltration by computed axial tomography (CT) or magnetic resonance imaging scan (MRI), 2) no evidence of leukemic infiltration on ophthalmologic examination, and 3) no previous radiotherapy to the brain. " 10/01/1974 - "[Radiotherapy of extramedullary foci of leukemic infiltration in acute leukosis]." 02/01/1999 - "The value of brain radiotherapy for leukemic patients with cranial nerve palsies in the absence of radiological evidence of leukemic infiltration is not well defined. " 01/01/1981 - "Formal pathogenesis is attributed to combined chemo- and radiotherapy in parallel to leukemic infiltration of vascular walls and partial obstruction of lumina by tumor emboli. " 07/01/2002 - "The presumptive diagnosis of leukemic infiltration of the optic nerves was made, and urgent radiotherapy, intrathecal methotrexate, and intravenous daunorubicin were instituted. "
5.	Hematopoietic Stem Cell Transplantation 01/01/2009 - "Leukemic infiltration of the lung following allogeneic hematopoietic stem cell transplantation."