Complement Factor H (Factor H)

An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

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Networked: 708 relevant articles (12 outcomes, 64 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zipfel, Peter F: 34 articles (11/2014 - 03/2002)
2.	Skerka, Christine: 20 articles (11/2014 - 02/2007)
3.	Frémeaux-Bacchi, Véronique: 16 articles (01/2016 - 03/2004)
4.	Pickering, Matthew C: 15 articles (04/2014 - 08/2002)
5.	Klein, Barbara E K: 13 articles (02/2015 - 09/2007)
6.	Klein, Ronald: 13 articles (02/2015 - 09/2007)
7.	Meri, Seppo: 13 articles (02/2014 - 10/2002)
8.	Iyengar, Sudha K: 11 articles (11/2015 - 09/2007)
9.	Dragon-Durey, Marie-Agnès: 11 articles (06/2015 - 03/2004)
10.	Marconi, Richard T: 11 articles (04/2012 - 06/2003)

Related Diseases

1.	Macular Degeneration (Age-Related Maculopathy) 11/14/2006 - "Polymorphisms in the complement factor H gene (CFH) are associated with a significantly increased risk for, or protection against, the development of age-related macular degeneration (AMD). " 09/01/2007 - "Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration." 01/01/2015 - "This study was aimed to confirm whether I62V and Y402H polymorphisms of complement factor H (CFH) were risk factors for age-related macular degeneration (AMD). " 02/01/2013 - "To study associations between severity stages of early and late age-related macular degeneration (AMD) and genetic variations in age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) and to investigate potential interactions between smoking and ARMS2. " 01/01/2013 - "The purpose of the study was to determine serum complement factor H (CFH) levels in patients of age related macular degeneration (AMD) and examine its association with CFH Y402H polymorphism. "
2.	Inflammation 06/01/2015 - "2-Hydroxypropyl-β-cyclodextrin is as effective in reducing Aβ and inflammation in the complement factor H knockout (Cfh(-/-)) mouse that shows advanced ageing and has been proposed as an AMD model. " 03/01/2013 - "Main genetic polymorphisms associated with risk of AMD development and progression were found to be genes that regulate inflammation especially in complement factor H gen (1q31 locus) and 10q26 locus (PLEKHAI/ARMS2/HTRA1). " 01/01/2013 - "Here we ask if 670 nm exposure has the same ability in an aged mouse model of AMD, the complement factor H knockout (CFH(-/-)) where inflammation is a key feature. " 04/01/2012 - "We conclude that under physiological conditions, Factor H may be important in controlling the inflammation which might arise from C1q deposition on apoptotic cells." 02/01/2012 - "Thus, factor H may be important in controlling the inflammation, which might arise from C1q deposition on apoptotic cells."
3.	Hemolytic-Uremic Syndrome 09/01/2003 - "Successful (?) therapy of hemolytic-uremic syndrome with factor H abnormality." 02/01/2001 - "Several recent studies have established an association between abnormalities of complement factor H (FH) and the development of hemolytic uremic syndrome (HUS). " 06/01/2014 - "Complement factor H-antibody-associated hemolytic uremic syndrome: pathogenesis, clinical presentation, and treatment." 05/01/2014 - "Anti-factor H autoantibody-associated hemolytic uremic syndrome: the earlier diagnosed and treated, the better." 04/01/2012 - "[A case of anti-factor H autoantibody-associated hemolytic uremic syndrome]."
4.	Lung Neoplasms (Lung Cancer) 09/01/2004 - "In this study, we examine the expression of factor H, an inhibitor of complement activation, and factor H-like protein 1 (FHL-1), its alternatively spliced form, in lung cancer. " 04/01/2012 - "Cigarette smoking strongly modifies the association of complement factor H variant and the risk of lung cancer." 10/01/2010 - "Factor H is elevated in bronchoalveolar lavage and sputum from lung cancer patients. " 10/01/2010 - "There was a significantly higher concentration of factor H in bronchoalveolar lavage samples from lung cancer patients. " 10/01/2010 - "Complement factor H is elevated in bronchoalveolar lavage fluid and sputum from patients with lung cancer."
5.	Glomerulonephritis 06/20/2006 - "Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice." 04/01/2014 - "Familial C3 glomerulonephritis has been associated with rearrangements affecting the complement factor H-related (CFHR) genes. " 11/01/2013 - "We also showed that FHL-1 (factor H-like protein 1) was present in the patient with aHUS and absent in the patient with glomerulonephritis. " 07/01/2012 - "Association of a novel complement factor H mutation with severe crescentic and necrotizing glomerulonephritis." 01/01/2012 - "C3 glomerulonephritis associated with a missense mutation in the factor H gene."

Related Drugs and Biologics

1.	Complement System Proteins (Complement)
2.	Immunoglobulin G (IgG)
3.	Proteins (Proteins, Gene)
4.	Autoantibodies
5.	Antigen-Antibody Complex (Immune Complex)
6.	Complement C3b (C3bi)
7.	Complement 3d Receptors (Complement Receptor 2)
8.	Propidium (Propidium Iodide)
9.	ofatumumab
10.	Complement Factor B (Factor B)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Plasmapheresis
3.	Transplants (Transplant)
4.	Plasma Exchange
5.	Photochemotherapy (Photodynamic Therapy)