Hepatocyte Growth Factor (Growth Factor, Hepatocyte)

Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.

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Networked: 2860 relevant articles (104 outcomes, 285 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nakamura, Toshikazu: 98 articles (04/2015 - 01/2002)
2.	Matsumoto, Kunio: 74 articles (01/2015 - 01/2002)
3.	Nakamura, T: 35 articles (01/2014 - 01/2000)
4.	Morishita, Ryuichi: 33 articles (01/2014 - 03/2002)
5.	Matsumoto, K: 26 articles (08/2006 - 01/2000)
6.	Laterra, John: 21 articles (04/2013 - 01/2002)
7.	Kaneda, Yasufumi: 21 articles (01/2013 - 07/2002)
8.	Sawa, Yoshiki: 20 articles (12/2013 - 05/2002)
9.	Mizuno, Shinya: 20 articles (01/2012 - 03/2004)
10.	Jiang, Wen G: 19 articles (01/2015 - 09/2003)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2009 - "As naked hepatocyte growth factor gene therapy via the hepatic artery proved simple, safe, and effective in larger animals with cirrhosis, this therapy may be clinically applicable." 02/01/2004 - "Hepatocyte growth factor ameliorates progression of interstitial fibrosis in rats with established renal injury." 10/01/2011 - "Several studies have shown that hepatocyte growth factor (HGF) ameliorates renal interstitial fibrosis, but the mechanism is not fully clear. " 04/01/2005 - "Previous studies demonstrated that hepatocyte growth factor (HGF) improved lung fibrosis in murine models, whereas molecular mechanisms whereby HGF improved lung fibrosis have yet to be fully understood. " 12/01/2010 - "Although hepatocyte growth factor (HGF) improved renal fibrosis in various models, the molecular mechanisms involved are not yet fully understood. "
2.	Ischemia 10/01/2015 - "Clinical Safety and Preliminary Efficacy of Plasmid pUDK-HGF Expressing Human Hepatocyte Growth Factor (HGF) in Patients with Critical Limb Ischemia." 08/01/2002 - "Hepatocyte growth factor ameliorates renal hemodynamic disorder after ischemia/reperfusion." 09/01/2011 - "This study was conducted in an attempt to use blood flow scintigraphy with 99mTc-hexakis-2-methyoxy-isobutylisonitrile (99mTc-MIBI) for the evaluation of the angiogenic effect of hepatocyte growth factor (HGF) plasmid in a rat model of hind limb ischemia. " 01/01/2011 - "However, in the present study, we investigated the therapeutic effects of hepatocyte growth factor modified hucMSCs (HGF-hucMSCs) in ischemia/reperfusion-induced AKI rat models. " 05/01/2010 - "Although hepatocyte growth factor (HGF) is also a potent angiogenic growth factor in animal models of ischemia, their characteristics are not the same in clinical trials. "
3.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2009 - "We previously reported successful therapy of liver cirrhosis in rats using the hepatocyte growth factor gene. " 03/01/2010 - "Administration of exogenous hepatocyte growth factor (HGF) may be potentially useful for the treatment of liver fibrosis. " 03/01/2000 - "Hepatocyte growth factor gene therapy may have the potential to be useful for the treatment of patients with liver cirrhosis." 01/01/2015 - "Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation." 08/01/2014 - "In this study, we demonstrate that hepatocyte growth factor (HGF), an antifibrotic factor in the process of pulmonary, renal and liver fibrosis, is a negative regulator of cardiac fibroblast transformation in response to transforming growth factor‑β1 (TGF‑β1). "
4.	Wounds and Injuries (Trauma) 10/01/2007 - "Hepatocyte growth factor (HGF) and its receptor are expressed in various regions of the brain and have protective effects against excitotoxic injuries. " 03/01/2010 - "Hepatocyte growth factor ameliorates progression of interstitial injuries in tubular epithelial cells." 02/02/2008 - "Hepatocyte growth factor (HGF) ameliorates liver injuries in hepatectomized cholestatic rats. " 03/27/2006 - "Hepatocyte growth factor (HGF) has been implicated in protection against several types of cell injuries. " 12/01/2010 - "[Study on bone marrow mesenchymal stem cells transfected with adenovirus hepatocyte growth factor gene promoting wounds repair in diabetic rats]."
5.	Inflammation 03/21/2008 - "Hepatocyte growth factor (HGF) ameliorates both acute and chronic inflammation in a multitude of organ systems through modulating NFkappaB activity; nevertheless, the exact molecular mechanism remains uncertain. " 04/01/2006 - "Evidence suggests that hepatocyte growth factor (HGF) ameliorates inflammation in animal models of renal disease, implying that HGF might inhibit specific components of the inflammatory response. " 01/01/2015 - "Recent genetic studies indicate that gene variants of an inflammation-related molecule, hepatocyte growth factor (HGF), are associated with an increased susceptibility for developing KC. " 06/16/2015 - "In this issue of Immunity, Komarowska et al. (2015) describe an autocrine loop that is initiated by cardiac-expressed hepatocyte growth factor to direct T cells into the heart during inflammation and cardiac transplant rejection." 04/01/2015 - "Hepatocyte growth factor: A regulator of inflammation and autoimmunity."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Collagen
4.	Protein Isoforms (Isoforms)
5.	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	Messenger RNA (mRNA)
8.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
9.	Transforming Growth Factor beta1 (TGF beta 1)
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Intramuscular Injections
3.	Ligation
4.	Microspheres (Microsphere)
5.	Total Parenteral Nutrition