Gastric Outlet Obstruction

The hindering of output from the STOMACH into the SMALL INTESTINE. This obstruction may be of mechanical or functional origin such as EDEMA from PEPTIC ULCER; NEOPLASMS; FOREIGN BODIES; or AGING.

Also Known As:

Networked: 554 relevant articles (53 outcomes, 50 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Neoplasms (Cancer)
4.	Vomiting
5.	Pancreatic Neoplasms (Pancreatic Cancer)

Experts

1.	Maetani, Iruru: 9 articles (04/2014 - 10/2005)
2.	Baron, Todd H: 6 articles (11/2015 - 01/2002)
3.	Isayama, Hiroyuki: 6 articles (01/2015 - 08/2007)
4.	Song, Ho-Young: 6 articles (10/2013 - 03/2002)
5.	Kang, Dae Hwan: 5 articles (01/2016 - 02/2007)
6.	van Hooft, Jeanin E: 5 articles (11/2015 - 05/2009)
7.	Tada, Minoru: 5 articles (01/2015 - 04/2012)
8.	Nakai, Yousuke: 5 articles (01/2015 - 04/2012)
9.	Ito, Yukiko: 5 articles (01/2015 - 04/2012)
10.	Kogure, Hirofumi: 5 articles (01/2015 - 04/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gastric Outlet Obstruction:

1.	nitinolIBA 08/01/2011 - "Safety and efficacy of a new non-foreshortening nitinol stent in malignant gastric outlet obstruction (DUONITI study): a prospective, multicenter study." 09/07/2010 - "A newly designed big cup nitinol stent for gastric outlet obstruction." 03/01/2002 - "Malignant gastric outlet obstructions: treatment by means of coaxial placement of uncovered and covered expandable nitinol stents." 09/07/2010 - "To find out whether a newly designed big cup nitinol stent is suitable for treatment of patients with gastric outlet obstruction resulting from gastric cancer. " 03/01/2002 - "To assess whether coaxial placement of uncovered and covered expandable nitinol stents overcomes the disadvantages of the increased migration rate seen with covered stents and the tumor ingrowth seen in uncovered stents in the treatment of malignant gastric outlet obstructions. "
2.	AntralIBA 01/01/2014 - "A polypoid lesion of approximately 25mm in diameter was detected in the antral area of the stomach, which prolapsed through the pylorus into the duodenal bulbus, and subsequently caused gastric outlet obstruction, as revealed by upper gastrointestinal endoscopy of the patient. " 09/01/2013 - "Gastric antral web: a rare cause of gastric outlet obstruction treated with endoscopic therapy." 03/01/2013 - "Antral web is a rare cause of gastric outlet obstruction in neonate. " 06/06/2011 - "[Prepyloric antral web--a rare cause of gastric outlet obstruction]." 01/01/2009 - "A case of gastric outlet obstruction secondary to antral web in a preterm infant born at 25 weeks gestation is reported. "
3.	CausticsIBA 10/01/2005 - "The literature on gastric outlet obstruction following ingestion of corrosives is reviewed briefly. " 10/01/2011 - "With improvement in science and technology, the spectrum of gastric outlet obstruction has changed from peptic ulcer disease to corrosives and malignant diseases. " 02/01/1988 - "Fifteen patients developed gastric outlet obstruction due to ingestion of corrosives, while another had midgastric stenosis due to formalin intake. "
4.	Pancrelipase (Creon)FDA Link 01/01/2015 - "This report suggests that pancrelipase may be beneficial in the treatment of patients with gastric outlet obstruction. " 01/01/2015 - "Pancrelipase allowed gastric contents to be evacuated in a short period of time in a patient with gastric outlet obstruction." 01/01/2015 - "Pretreatment of gastric outlet obstruction with pancrelipase: Report of a case." 01/01/2015 - "We treated a patient with advanced gastric cancer and gastric outlet obstruction with pancrelipase to aid in the removal of gastric contents. "
5.	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 07/01/2012 - "Furthermore, in vivo administration of NS-398 in gastric outlet obstruction significantly improved gastric emptying. "
6.	BariumIBA 06/01/2011 - "Barium study revealed complete/near-complete gastric outlet obstruction in all patients. " 02/01/2007 - "Gastric outlet obstruction was strictly defined to include patients with clinical delayed gastric emptying supported by symptoms, barium swallow studies, persistent air-fluid level and dilated conduit on radiography, or endoscopic or surgical intervention to improve gastric drainage. " 10/01/1995 - "The diagnosis of gastric outlet obstruction was based on clinical presentation, an upper gastrointestinal barium study, and/or an inability during upper endoscopy to intubate the second portion of the duodenum. " 12/01/1994 - "Upper GI endoscopy and barium studies confirmed the diagnosis of functional gastric outlet obstruction. " 01/01/2012 - "Barium meal revealed herniation of the stomach through the gastric wall causing gastric outlet obstruction. "
7.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 04/01/2004 - "Both have been shown to reduce the risk of symptomatic ulcers and ulcer complications (perforation, gastric outlet obstruction, bleeding) by about 50% compared to classical NSAIDs used at their maximum therapeutic doses. " 07/01/2000 - "The aim of this study was to assess the rate of upper gastrointestinal (UGI) ulcer complications (bleeding, perforation, or gastric outlet obstruction) associated with celecoxib, a specific COX-2 inhibitor, compared with the rate associated with nonspecific, nonsteroidal anti-inflammatory drugs (NSAIDs). " 08/15/1995 - "To investigate whether concurrent administration of misoprostol reduces the occurrence of serious upper gastrointestinal complications, such as perforation, gastric outlet obstruction, or bleeding, in patients with rheumatoid arthritis who are receiving nonsteroidal anti-inflammatory drugs (NSAIDs). " 09/28/2002 - "The probability of developing a symptomatic, uncomplicated or complicated (perforation, gastric outlet obstruction, bleeding) gastroduodenal ulcer is significantly lower with a COX-2 selective inhibitor (Celecoxib, rofecoxib) than with a traditional NSAIDs, with a reduction in absolute risk of around 1-1.5 for 100 patient-years in clinical trials. "
8.	celecoxib (Celebrex)FDA Link 07/01/2000 - "The aim of this study was to assess the rate of upper gastrointestinal (UGI) ulcer complications (bleeding, perforation, or gastric outlet obstruction) associated with celecoxib, a specific COX-2 inhibitor, compared with the rate associated with nonspecific, nonsteroidal anti-inflammatory drugs (NSAIDs). " 09/28/2002 - "The probability of developing a symptomatic, uncomplicated or complicated (perforation, gastric outlet obstruction, bleeding) gastroduodenal ulcer is significantly lower with a COX-2 selective inhibitor (Celecoxib, rofecoxib) than with a traditional NSAIDs, with a reduction in absolute risk of around 1-1.5 for 100 patient-years in clinical trials. "
9.	Alprostadil (Muse)FDA LinkGeneric 05/01/2013 - "Study of the case and of available literature showed an association between the total dose of prostaglandin E1 administered and duration of treatment and the development of gastric outlet obstruction. " 05/01/2013 - "We conclude that if patients are treated with a prostaglandin E1 infusion, careful monitoring for symptoms and signs of gastric outlet obstruction is required." 09/18/1993 - "Prostaglandin E1 and gastric outlet obstruction in infants." 08/20/1992 - "We evaluated all neonates who received prostaglandin E1 in our hospital between October 1, 1989, and September 30, 1991, for clinical, radiologic, or pathological evidence of acute gastric-outlet obstruction. " 08/20/1992 - "After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication. "
10.	Misoprostol (Cytotec)FDA LinkGeneric 01/01/1996 - "Recently, the Misoprostol Ulcer Complications Outcomes Safety Assessment trial demonstrated that misoprostol also reduces the most serious complications of NSAID-induced ulcers, namely bleeding, perforation, and gastric outlet obstruction." 12/01/2007 - "Full-dose misoprostol reduced bleeding, perforation or gastric outlet obstruction due to NSAID-induced ulcers, but misoprostol was poorly tolerated and associated with frequent adverse effects. " 08/15/1995 - "To investigate whether concurrent administration of misoprostol reduces the occurrence of serious upper gastrointestinal complications, such as perforation, gastric outlet obstruction, or bleeding, in patients with rheumatoid arthritis who are receiving nonsteroidal anti-inflammatory drugs (NSAIDs). "

Therapies and Procedures

1.	Stents 10/01/2004 - "Uncovered stents are technically feasible and effective for most malignant gastric outlet obstructions. " 07/01/2010 - "Large-diameter stent placement may be clinically effective in gastric outlet obstruction cases with a high risk of stent migration as a result of mild obstructions or unusual obstruction location." 10/01/2001 - "Peroral intubation of a self-expanding coil stent using a long delivery system is a safe and effective palliative technique for unresectable malignant gastric outlet obstruction, and significantly improves the quality of life of patients." 01/01/2015 - "Secondary gastroduodenal stent placement might be effective for managing first stent dysfunction in malignant gastric outlet obstruction. " 10/01/2013 - "Additional gastroduodenal stent placement is technically feasible and clinically effective for patients with recurrent gastric outlet obstruction after stent placement."
2.	Palliative Care (Palliative Medicine) 08/01/1998 - "Endoscopic palliative treatment may be effective in the management of malignant gastric outlet obstruction. " 09/01/2007 - "Palliative care of malignant gastric outlet obstruction symptoms is critical for improved quality of life. " 01/01/2007 - "The paucity of evidence from large randomized trials may however have influenced the results and therefore a trial of sufficient size is needed to determine which palliative treatment modality is optimal in (sub)groups of patients with malignant gastric outlet obstruction." 01/01/2014 - "In the palliative treatment of malignant gastric outlet obstruction, both covered and uncovered SEMSs are safely and effective. " 01/01/2014 - "Palliative treatment of gastric outlet obstruction in terminal patients: SEMS. "
3.	Gastric Bypass (Roux-en-Y Gastric Bypass) 08/01/2005 - "We present a case of gastric outlet obstruction due to TB that was treated successfully with a minimally invasive approach, without the need for a gastric bypass." 09/01/2008 - "In conclusion, our gasless, laparoscopy-assisted gastrojejunostomy procedure appears to be both safe and effective in patients with gastric outlet obstruction." 11/01/2012 - "Although endoscopic stenting is increasingly performed, surgical gastrojejunostomy (GJ) is still considered the gold standard for relief of malignant gastric outlet obstruction (GOO). " 04/01/2014 - "Endoscopic stenting versus operative gastrojejunostomy for malignant gastric outlet obstruction-a systematic review and meta-analysis of randomized and non-randomized trials." 09/01/2013 - "This and a previous study from the authors' institution show that PSPG is a good alternative for palliative bypass in the setting of malignant gastric outlet obstruction over classic gastrojejunostomy."
4.	Balloon Dilation 05/01/1996 - "The aim of this study is to identify factors that will predict which patients with benign gastric outlet obstruction will not respond to endoscopic balloon dilation, in a long-term observation. " 07/01/2014 - "Her course was complicated by recurrent episodes of radiation-induced gastric outlet obstruction requiring balloon dilations. " 12/16/2010 - "Endoscopic pyloric balloon dilation has been shown to be a safe procedure in treating gastric outlet obstruction in older children and adults. " 04/01/2010 - "There are no reports on endoscopic balloon dilation (EBD) for caustic-induced gastric outlet obstruction (GOO) in the acute or subacute phase. " 01/16/2010 - "Endoscopic balloon dilation for benign gastric outlet obstruction in adults."
5.	Vagotomy 05/01/1996 - "The good results obtained after antrectomy with selective vagotomy encourage us to use it as the main procedure for gastric outlet obstruction. " 05/01/2005 - "One child with gastric outlet obstruction underwent vagotomy and antrectomy and 1 had vagotomy and pyloroplasty. " 11/01/1997 - "The patient who had gastric outlet obstruction had vagotomy and antrectomy. " 07/01/1994 - "A patient with a previous vagotomy and pyloroplasty was evaluated for symptoms of gastric outlet obstruction. " 01/01/1993 - "During the last 100 years, since Cesar Roux (1857-1934) began utilizing his "Loop-en-Y" procedure for gastric outlet obstruction, this technique fell into disfavour but later, with the vagotomy, it was adapted for multiple applications. "