Anticardiolipin Antibodies

Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.

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Networked: 1878 relevant articles (14 outcomes, 173 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cervera, Ricard: 9 articles (02/2014 - 01/2003)
2.	Galli, Monica: 7 articles (06/2012 - 11/2002)
3.	de Godoy, José Maria Pereira: 7 articles (01/2010 - 01/2002)
4.	Khamashta, M A: 7 articles (10/2008 - 12/2001)
5.	Atsumi, Tatsuya: 6 articles (01/2014 - 12/2002)
6.	Espinosa, Gerard: 6 articles (11/2013 - 03/2003)
7.	Koike, Takao: 6 articles (06/2008 - 09/2002)
8.	Shoenfeld, Y: 6 articles (01/2007 - 05/2000)
9.	Glueck, Charles J: 5 articles (12/2015 - 12/2004)
10.	Khamashta, Munther A: 5 articles (11/2015 - 05/2002)

Related Diseases

1.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 09/01/2004 - "In this study we sought to assess (1) the diagnostic value of a combined search for anti-beta(2)-glycoprotein (abeta(2)-GPIs) and anticardiolipin antibodies (aCLs) in primary (APS I) and secondary (APS II) antiphospholipid syndrome and (2) the influence of the beta(2)-GPI preparation in the ELISA's results. " 03/01/2003 - "To test the feasibility of applying a mimetic (specific for a patient-derived prothrombotic anticardiolipin antibody [aCL]) to study the homologous, disease-associated aCL in patients with antiphospholipid syndrome (APS). " 05/01/2000 - "Eleven patients with antiphospholipid syndrome (study group) and 11 healthy controls, matched by maternal and gestational age (control group) were prospectively examined for the presence of anticardiolipin antibodies in the cord blood during labour, and amniotic fluid during vaginal or Caesarean delivery. " 05/01/2000 - "The aim of this study was to investigate whether, in patients with antiphospholipid syndrome, anticardiolipin antibodies pass from mother to offspring sera and amniotic fluid. " 06/01/1995 - "To study whether monoclonal anticardiolipin antibodies (aCL), derived from patients with antiphospholipid syndrome (APS), have similar pathogenic potential, we have employed an experimental model of antiphospholipid syndrome. "
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/01/2000 - "This study was conducted to determine the prevalence and clinical association of anticardiolipin antibodies (ACA) in serum of patients with systemic lupus erythematosus (SLE). " 11/01/1997 - "The study of anticardiolipin antibodies in cerebrospinal fluid was useful to detect active neuropsychiatric disease in systemic lupus erythematosus." 02/01/1995 - "The aim of the study was to investigate the frequency and clinical significance of anticardiolipin antibodies (aCL) in systemic lupus erythematosus (SLE). " 06/01/1993 - "The objective of this study is to determine whether patients with systemic lupus erythematosus (SLE) and anticardiolipin antibodies (ACA) have biochemical evidence of an ongoing prothrombotic state. " 02/01/1993 - "The aim of this study was to assess the relationship between the incidence and severity of valvular regurgitation and the presence of high levels of anticardiolipin antibodies in a group of patients with systemic lupus erythematosus. "
3.	Thrombosis (Thrombus) 05/01/2015 - "Role of anticardiolipin antibodies in the pathogenesis of prosthetic valve thrombosis: An observational study." 01/01/2010 - "In this study, we aimed to evaluate the importance of clinical and biochemical parameters including anticardiolipin antibodies on left ventricular thrombus formation after acute anterior MI. " 06/01/2005 - "The aim of the study was to investigate whether anti-beta-2-glycoprotein I (anti-beta2GPI) or anticardiolipin antibodies (ACA) are associated with an increased risk of thrombosis in patients persistently positive for LA. " 03/01/2003 - "Sixteen studies served to assess 28 associations between anticardiolipin antibodies and thrombosis: the odds ratio with 95% CI was significant in 15 cases. " 06/01/2000 - "The aim of this study was to assess prospectively the prevalence of anticardiolipin antibodies in patients with peripheral arterial thrombosis. "
4.	Stroke (Strokes) 10/01/2005 - "In the single study that found no increased risk for stroke, only anticardiolipin antibody was tested. " 03/01/2002 - "The purpose of the present prospective observational study was to assess whether or not the presence of anticardiolipin antibodies (aCL) in unselected first ischemic stroke patients is associated with adverse outcome. " 04/01/1996 - "In this study, only one patient without anticardiolipin antibodies developed a cerebrovascular accident. " 04/01/1991 - "Anticardiolipin antibodies: a study of frequency in TIA and stroke." 03/01/2014 - "Anticardiolipin antibodies are associated with cognitive dysfunction in stroke-free individuals."
5.	Spontaneous Abortion (Miscarriage) 08/01/1992 - "Relative risk of miscarriage in anticardiolipin antibody-positive patients compared with anticardiolipin antibody-negative patients was 1.3 (95% confidence interval 0.7 to 2.2; P = 0.4) in the combined study groups. " 01/01/2010 - "In conclusion, women who suffer from repeated miscarriages present with a high prevalence of anticardiolipin antibodies. " 01/01/2010 - "Prevalence of anticardiolipin antibodies in pregnancies with history of repeated miscarriages." 09/01/2006 - "To determine the association between the presence of anticardiolipin antibody (ACA) and history of recurrent spontaneous miscarriage. " 09/01/2006 - "Anticardiolipin antibody in women with recurrent spontaneous miscarriage."

Related Drugs and Biologics

1.	Lupus Coagulation Inhibitor (Lupus Anticoagulant)
2.	Antibodies
3.	Antiphospholipid Antibodies
4.	Immunoglobulin M (IgM)
5.	Antinuclear Antibodies
6.	Immunoglobulin G (IgG)
7.	Anticoagulants
8.	Immunoglobulins (Immunoglobulin)
9.	Autoantibodies
10.	Steroids

Related Therapies and Procedures

1.	Liver Transplantation
2.	Splenectomy
3.	Renal Dialysis (Hemodialysis)
4.	Plasmapheresis
5.	Amputation