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Desogestrel

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A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.

Also Known As:

13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol; Cerazette; Marvelon; Org-2969; Organon Brand of Desogestrel; 13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol; Org 2969; Org2969; alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17; 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17alpha)-

Networked: 239 relevant articles (19 outcomes, 52 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Norsteroids: 12
    - Norpregnanes: 1
      - Norpregnenes
        Desogestrel: 239
        3-keto-desogestrel: 111
        NuvaRing: 17
        Oviol: 10
        ethinyl estradiol-desogestrel combination: 2

Experts

1.	Helmerhorst, Frans M: 5 articles (01/2014 - 05/2002)
2.	Grimes, David A: 5 articles (01/2013 - 01/2009)
3.	Lopez, Laureen M: 5 articles (01/2013 - 01/2009)
4.	Merki-Feld, Gabriele S: 4 articles (01/2015 - 01/2013)
5.	Remorgida, Valentino: 4 articles (12/2014 - 06/2007)
6.	Ferrero, Simone: 4 articles (12/2014 - 06/2007)
7.	Lidegaard, Øjvind: 4 articles (10/2014 - 01/2009)
8.	Rosendaal, Frits R: 4 articles (01/2014 - 05/2002)
9.	Rosing, J: 4 articles (06/2012 - 07/2000)
10.	Helmerhorst, F M: 4 articles (01/2009 - 08/2002)

Related Diseases

1.	Hirsutism 11/01/1991 - "Oral contraceptive containing desogestrel in the maintenance of the remission of hirsutism: monthly versus bimonthly treatment." 01/01/1989 - "Short-term treatment of hirsutism related to micropolycystic ovary syndrome with a combination type oral contraceptive containing desogestrel." 01/01/1993 - "Desogestrel's low androgenicity accounts for low incidences of acne and hirsutism. " 01/01/1985 - "Twenty women suffering from a polycystic ovary syndrome (PCO) accompanied by hirsutism were given a low-dose oral contraceptive combination containing 0.150 mg desogestrel plus 0.030 mg ethinylestradiol for 8 months. " 10/01/2000 - "The BMD before and after 12 months of treatment showed no statistically significant difference between the patients of group 1 and those of group 2, suggesting that both ethinylestradiol plus desogestrel, and ethinylestradiol and desogestrel plus spironolactone daily for 12 months at the given doses do not affect the BMD of the treated women, while the addition of spironolactone improves the efficacy of hirsutism treatment."
2.	Acne Vulgaris 01/01/1986 - "Acne improved significantly in both groups, desogestrel/EE showing greater improvement. " 01/01/1986 - " Although acne improved in both groups, the improvement was greatest among cases receiving a desogestrel-containing OC. " 07/01/1996 - " The percentage of women with moderate/severe acne decreased significantly with Marvelon at Center B (p = 0.002) and with Diane in Centers A (p = 0.014) and B (p = 0.004). " 07/01/1996 - "The decrease in percentage of severe/moderate acne was statistically significant with Marvelon in Center B (P = 0.002) and with Diane in Centers A (P = 0.014) and B (P = 0.004). " 07/01/1996 - "In Center B, a consistent and significant decrease in mean acne score was observed with Marvelon after three and six treatment cycles (P < .05 and P < .01) and with Diane after six treatment cycles (P < .001). "
3.	Hemorrhage 11/01/2014 - "Intraoperative data showed no significant differences between the two groups for cervical dilatation time (p = 0.160), while in the desogestrel group we found a significant reduction of operative time (p = 0.020), infusion volume (p = 0.012), and severity of bleeding (p = 0.004). " 01/01/2015 - "Despite the increased contraceptive efficacy of a desogestrel-only pill compared with a traditional POP, POPs are still not widely used due to an unpredictable bleeding pattern. " 08/01/1991 - "The study results suggest that Marvelon offers an effective and acceptable method of postponing withdrawal bleeding for three weeks for most regular users of this contraceptive." 08/01/1991 - "This study investigated the ability of a monophasic sub-50 oral contraceptive, containing desogestrel and ethinylestradiol, to postpone withdrawal bleeding in normal healthy women. " 01/01/2013 - "However, the desogestrel progestin-only pill caused more bleeding problems, although this difference was not statistically significant. "
4.	Azoospermia 11/01/2002 - "Azoospermia was achieved in 8/10 and 8/12 men in the 150 micro g and 300 micro g desogestrel groups. " 06/01/2002 - "Azoospermia was achieved by a higher proportion of men in the 300 microg desogestrel group: 28/28 men versus 22/31 men (P < 0.05). " 11/01/2002 - "These data demonstrate that the combination of oral desogestrel with depot testosterone is an effective regimen for suppression of spermatogenesis in African as in Caucasian and Chinese men, with azoospermia achieved in a total of 83/98 (85%) men." 06/01/2002 - "This combination of oral desogestrel with depot testosterone maintains physiological testosterone concentrations with consistent suppression of spermatogenesis to azoospermia in both Caucasian and Chinese men and therefore has many of the properties necessary for a contraceptive preparation for men." 06/01/2002 - "Oral desogestrel with testosterone pellets induces consistent suppression of spermatogenesis to azoospermia in both Caucasian and Chinese men."
5.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/01/1985 - "Lipid metabolic studies in women with a polycystic ovary syndrome during treatment with a low-dose desogestrel-ethinylestradiol combination." 01/01/1985 - "Twenty women suffering from a polycystic ovary syndrome (PCO) accompanied by hirsutism were given a low-dose oral contraceptive combination containing 0.150 mg desogestrel plus 0.030 mg ethinylestradiol for 8 months. " 01/01/2012 - "The aim of this study was to examine the therapeutic effects of an ethinyl estradiol (EE) and desogestrel (DSG) combination pill in polycystic ovary syndrome (PCOS). " 01/01/2012 - "Effects of ethinyl estradiol and desogestrel on clinical and metabolic parameters in Indian patients with polycystic ovary syndrome." 08/01/2010 - "A prospective randomized trial was conducted to compare efficacy of a drospirenone-containing combined oral contraceptives (COC) with desogestrel-containing COC in women with polycystic ovary-syndrome (PCOS) not desirous of child-bearing. "

Related Drugs and Biologics

1.	Ethinyl Estradiol (Estinyl)
2.	Levonorgestrel (Plan B)
3.	Testosterone (Sustanon)
4.	Oral Contraceptives
5.	drospirenone
6.	Combined Oral Contraceptives
7.	Hormones
8.	Diane
9.	testosterone undecanoate
10.	Org 31710

Related Therapies and Procedures

1.	Contraception (Birth Control)
2.	Injections
3.	Ovulation Inhibition
4.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
5.	Transdermal Patch