Advanced Glycation End Products

A heterogeneous group of compounds derived from rearrangements, oxidation, and cross-linking reactions that follow from non-enzymatic glycation of amino groups in PROTEINS; LIPIDS; or NUCLEIC ACIDS. Their accumulation in vivo accelerates under hyperglycemic, oxidative, or inflammatory conditions. Heat also accelerates the formation of advanced glycation end products (AGEs) such seen with the browning of food during cooking.

Also Known As:

Glycation End Products, Advanced; Advanced Glycation Endproducts; Advanced Maillard Reaction End Products; Glycation Endproducts, Advanced; Maillard Products; Maillard Reaction End Products; Maillard Reaction Products; Glycation Endproduct, Advanced; Lipids, Glycated; Product, Maillard Reaction; Products, Maillard; Products, Maillard Reaction; Reaction Products, Maillard; Advanced Glycation End Product; Advanced Glycation Endproduct; Advanced Maillard Reaction End Product; Glycated Lipids; Glycotoxins; Maillard Product; Maillard Reaction End Product; Maillard Reaction Product

Networked: 4609 relevant articles (63 outcomes, 374 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Takeuchi, Masayoshi: 100 articles (12/2022 - 06/2002)
2.	Yamagishi, Sho-ichi: 88 articles (11/2015 - 06/2002)
3.	Matsui, Takanori: 85 articles (08/2021 - 08/2005)
4.	Schalkwijk, Casper G: 65 articles (01/2022 - 01/2002)
5.	Yamagishi, Sho-Ichi: 54 articles (08/2021 - 02/2003)
6.	Yamagishi, S: 43 articles (03/2016 - 08/2000)
7.	Forbes, Josephine M: 39 articles (06/2022 - 11/2002)
8.	Uribarri, Jaime: 39 articles (03/2022 - 03/2003)
9.	Schmidt, Ann Marie: 39 articles (01/2022 - 09/2000)
10.	Cooper, Mark E: 38 articles (01/2020 - 10/2001)

Related Diseases

1.	Inflammation (Inflammations) 11/01/2023 - "The present study evaluated whether advanced glycation end products (AGEs) and their receptor (RAGE), known to mediate obesogenic diet-induced inflammation and pathological metabolic conditions, are involved in this behavioral change. " 01/01/2023 - "In addition to traditional mechanisms such as the production and accumulation of advanced glycation end products (AGEs), angiopathy, tissue glycation, oxidative stress, and systemic inflammation, recent studies have focused on programmed cell deaths (PCDs), especially the non-apoptotic ones, in diabetic pulmonary dysfunction. " 11/15/2021 - "Previous studies showed that advanced glycation end products (AGEs) up-regulated in diabetic patients and induced a series of cellular effects such as oxidative stress, inflammation, and autophagy. " 01/01/2019 - "In this study, we investigated the inhibitory effect of DMA on advanced glycation end product- (AGE-) induced inflammation in macrophages and macrophage-endothelial cocultures. " 01/01/2019 - "In addition, recent studies have suggested that the MR products, in particular "advanced glycation end products (AGEs)," contained in the diet may be involved in the development of chronic inflammation by acting as inflammatory components and affecting the gut microbiome. "
2.	Insulin Resistance 12/01/2017 - "We have previously shown that an isoenergetic low advanced glycation end products (AGEs) diet matched for macronutrient content improved insulin sensitivity compared to high AGE diet. " 01/01/2021 - "Furthermore, exercise improved metabolic insulin sensitivity by 21%, which paralleled rises in NOGD (p = 0.05) and decreases in soluble receptors for advanced glycation end products (condition effect: p = 0.01). " 06/21/2023 - "Of the many dietary influences that may play a role in aging-related decreased insulin sensitivity, advanced glycation end products (AGEs) appear particularly important. " 11/21/2022 - "α-Dicarbonyls and advanced glycation end products (AGEs) may contribute to the pathogenesis of insulin resistance by a variety of mechanisms. " 11/21/2022 - "Association of α-Dicarbonyls and Advanced Glycation End Products with Insulin Resistance in Non-Diabetic Young Subjects: A Case-Control Study."
3.	Hyperglycemia 03/01/2019 - "Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans." 01/01/2013 - "Biochemical and molecular studies showed that hyperglycemia induced activation of NF-κB, signaling and actions of advanced glycation end products and other inflammatory mediators play key roles in the expression of pathological genes. " 04/01/2010 - "In the present study, we tested whether exposure to advanced glycation end-products (AGEs) impairs vascular reactivity independently of hyperglycemia and examined the potential mechanisms responsible for diabetes and AGE-associated vascular dysfunction. " 11/04/2023 - "Accumulation of advanced glycation end products (AGEs) in hyperglycemia may impair cell function and worsen periodontal conditions. " 07/01/2023 - "Advanced glycation end products (AGEs) are mediators in the process of cellular dysfunction in response to hyperglycemia. "
4.	Type 2 Diabetes Mellitus (MODY) 01/01/2021 - "It is hypothesized that decreased advanced glycation end products (AGEs) levels could affect type 2 diabetes mellitus (T2DM) remission in newly diagnosed patients through the consumption of two healthy diets. " 05/01/2023 - "Dietary modulation of advanced glycation end products metabolism on carotid intima-media thickness in type 2 diabetes patients: From the CORDIOPREV study." 01/01/2023 - "Previous studies have reported that advanced glycation end products (AGEs) were related to cardiovascular events in type 2 diabetes. " 01/10/2022 - "The PubMed, Web of Science, LILACS, and Cochrane Library databases were searched, using the terms "type 2 diabetes," "advanced glycation end products" and "diet." Seven original studies were included in this review. " 01/01/2021 - "Preclinical studies have found impaired osteogenic differentiation to be associated with type 2 diabetes (T2DM), which is related to skeletal accumulation of advanced glycation end products (AGEs). "
5.	Diabetic Nephropathies (Diabetic Nephropathy) 09/01/2022 - "Advanced glycation end-product inhibitors and treatments related to epigenetics have also shown promise as potential diabetic kidney disease treatments in preclinical studies. " 03/28/2019 - "Previous studies have shown that accumulation of advanced glycation end products (AGEs) can be the cause of diabetic nephropathy (DN) in diabetic patients. " 01/01/2017 - "In this study, we explored whether DJC can ameliorate advanced glycation end products- (AGEs-) mediated cell injury and the precise mechanisms of DJC in treating diabetic nephropathy (DN). " 01/01/2017 - "A recent study demonstrated that advanced glycation end products (AGEs) play a role in monocyte infiltration in mesangial areas in diabetic nephropathy. " 01/01/2014 - "In our study, we hypothesized that receptors for advanced glycation end-products (RAGE) mediate endoplasmic reticulum (ER) stress to induce premature senescence via p21 signaling activation in diabetic nephropathy. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Receptor for Advanced Glycation End Products
3.	Cytokines
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	N(6)-carboxymethyllysine (carboxymethyllysine)
6.	pentosidine
7.	Antioxidants
8.	Streptozocin (Streptozotocin)
9.	Ligands
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Therapeutics
3.	Peritoneal Dialysis
4.	Glycemic Control
5.	Mediterranean Diet