HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Protein Tyrosine Phosphatases

Subscribe to New Research on Protein Tyrosine Phosphatases

An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.

Also Known As:

PTPase; Phosphotyrosyl Protein Phosphatase; Protein-Tyrosine Phosphatase; Phosphatase, Phosphotyrosine; Phosphatase, Phosphotyrosyl Protein; Phosphatase, Protein-Tyrosine; Phosphatase, Tyrosyl Phosphoprotein; Phosphatases, Protein Tyrosine; Phosphoprotein Phosphatase, Tyrosyl; Protein Phosphatase, Phosphotyrosyl; Protein Tyrosine Phosphatase; Tyrosine Phosphatases, Protein; Phosphotyrosine Phosphatase; Protein-Tyrosine-Phosphatase; Tyrosyl Phosphoprotein Phosphatase; Protein-tyrosine-phosphate phosphohydrolase

Networked: 965 relevant articles (8 outcomes, 90 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Esterases: 217
      - Phosphoric Monoester Hydrolases: 1062
        Protein Tyrosine Phosphatases: 965
        prostatic acid phosphatase: 698
        Dual-Specificity Phosphatases: 151
        SH2 Domain-Containing Protein Tyrosine Phosphatases: 5
        phosphotyrosine phosphatase eta: 2
        Receptor-Like Protein Tyrosine Phosphatases: 2
        human EYA1 protein: 1
        mouse Eya1 protein: 1
        Non-Receptor Protein Tyrosine Phosphatases: 1
        Arabidopsis At3g52180 protein
        Arabidopsis EYA protein
        Arabidopsis PHS1 protein
        C elegans EAK-4 protein
        C elegans EAK-6 protein
        C elegans EGG-3 protein
        C elegans eya-1 protein
        C elegans IDA-1 protein
        C elegans lip-1 protein
        C elegans myotubularin-9 protein
        C elegans SDF-9 protein
        Drosophila EDTP protein
        Drosophila Kek1 protein
        Drosophila Mop protein
        Drosophila Pez protein
        Drosophila PTP-ER protein
        Drosophila Ptp10D protein
        Drosophila Ptp52F protein
        Drosophila stg protein
        Hirudo medicinalis HmLAR1 protein
        Hirudo medicinalis HmLAR2 protein
        human ACP1 protein
        human B59 protein
        human DDSP protein
        human EYA2 protein
        human EYA3 protein
        human FAM82A2 protein
        human HISPPD2A protein
        human prostatic acid phosphatase (248-286)
        human PTP4A1 protein
        human PTP4A2 protein
        human PTP4A3 protein
        human PTPLA protein
        human PTPLB protein
        low-molecular-mass dual-specificity phosphatase-2
        mouse Acp1 protein
        mouse CDC14A protein
        mouse Cdkn3 protein
        mouse Eya2 protein
        mouse MKP2 protein
        mouse Ptp4a1 protein
        mouse Ptp4a2 protein
        mouse Ptp4a3 protein
        mouse Ptpcd-1 protein
        mouse PTPIP51 protein
        mouse Ptpla protein
        Mycobacterium tuberculosis MptpA protein
        Nostoc protein-tyrosine phosphatase
        rat Acp1 protein
        rat PRL-3 protein
        rat Ptp4a1 protein
        rat PTPIP51 protein
        rat PTPLA protein
        S cerevisiae CDC14 protein
        S cerevisiae LTP1 protein
        S cerevisiae MIH1 protein
        S cerevisiae MSG5 protein
        S cerevisiae PPS1 protein
        S cerevisiae Ptp2 protein
        S cerevisiae PtpB protein
        S cerevisiae Siw14 protein
        S cerevisiae YGR203w protein
        S pombe FLP1 protein
        S pombe pyp1 protein
        S pombe pyp2 protein
        S pombe pyp3 protein
        S pombe Stp1 protein
        Salmonella typhimurium sptP protein
        Streptococcus pneumoniae CpsB protein
        Xenopus Eya1 protein
        Xenopus eya3 protein
        Xenopus FRIED protein
        Xenopus PTPX1 protein
        Xenopus PTPX10 protein
        Yersinia enterocolitica yop51 protein
        Yersinia yopH protein
        zebrafish eya1 protein
        zebrafish Pez protein

Experts

1.	Lombroso, Paul J: 12 articles (03/2015 - 03/2007)
2.	Neel, Benjamin G: 10 articles (01/2015 - 04/2002)
3.	Mustelin, Tomas: 10 articles (05/2013 - 01/2002)
4.	Tremblay, Michel L: 9 articles (03/2012 - 12/2005)
5.	Scharl, Michael: 8 articles (10/2015 - 12/2009)
6.	Brady-Kalnay, Susann M: 8 articles (01/2015 - 03/2002)
7.	Xu, Jian: 8 articles (07/2014 - 05/2008)
8.	Tartaglia, Marco: 8 articles (08/2012 - 10/2002)
9.	Song, Gwan Gyu: 7 articles (08/2013 - 03/2012)
10.	Lee, Young Ho: 7 articles (08/2013 - 03/2012)

Related Diseases

1.	Insulin Resistance 12/01/2001 - "These studies provide the first demonstration that endogenous PTPase activity, including PTP1B, is increased in om adipose tissue and may contribute to the relative insulin resistance of this fat depot. " 12/01/2008 - "This signaling is countered by protein tyrosine phosphatases (PTPases), which reportedly are associated with insulin resistance that can be reduced by regulation of PTPases. " 06/06/2005 - "Knock-down of LAR protein tyrosine phosphatase induces insulin resistance." 05/16/2005 - "[The role of protein tyrosine phosphatase (PTP-1B) in insulin resistance]." 07/01/2002 - "PTPase activity does not rise in activity as a result of insulin resistance and nutritionally induced diabetes."
2.	Diabetes Mellitus 02/01/2014 - "Biochemical, epidemiological and experimental evidence suggests that cytosolic low molecular weight protein-tyrosine phosphatase (cLMWPTP) genetic variability may have a role in the clinical manifestations of diabetes mellitus. " 03/01/2011 - "The study has been designed to investigate downstream mechanisms in the PTPase inhibition mediated attenuation of diabetes mellitus and hypercholesterolemia-induced vascular endothelial dysfunction. " 03/01/2006 - "The study has been designed to investigate the effect of Bis-(maltolato) oxovanadium (BMOV), an inhibitor of protein tyrosin phosphatase (PTPase), in diabetes mellitus and hyperhomocysteinemia induced vascular endothelial dysfunction. " 03/01/2011 - "Mechanism of attenuation of diabetes mellitus and hypercholesterolemia induced vascular endothelial dysfunction by protein tyrosine phosphatase inhibition." 08/01/2007 - "Insulinoma-associated protein (IA)-2 beta, an inactive member of the protein-tyrosine phosphatase (PTP) family, is a major autoantigen in type-1 diabetes mellitus. "
3.	Shock 11/01/1992 - "We could demonstrate a correlation between the dose of stress stimuli effective in increasing PTPase activity and p56lck activation using heat shock and Hg2+ as stress stimuli. " 01/01/2015 - "Herein, we provide new contribution to the mechanisms involved in keratinocytes response to hyperosmotic shock showing, for the first time, the participation of Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP) activity in this event. " 04/01/1995 - "Protein-tyrosine phosphatase is also induced by heat shock and chemical stress, whereas COX-2 is not. " 11/01/1992 - "The heavy metal Hg2+ and heat shock stimulated PTPase activity at an optimal dose, whereas the oxidant phenylarsine oxide (PAO) was only marginally stimulatory. " 12/01/2014 - "The population study was composed of 61 RA patients under different therapies and 52 healthy controls, whereas the antigens tested were MTB lipoarabinomannan (ManLAM), MAP heath shock protein 70, and MAP protein tyrosine phosphatase. "
4.	Experimental Arthritis 12/01/2008 - "Inhibition of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 reduces the severity of collagen-induced arthritis." 06/01/2014 - "Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats." 06/01/2014 - "To study the expression level of peptidylarginine deiminase 4 (PADI4) and protein tyrosine phosphatase nonreceptor type 22 (PTPN22) in the synovium of rat model of collagen-induced arthritis, and to explore their possible therapeutic role in rheumatoid arthritis. "
5.	Glioma (Gliomas) 09/30/2014 - "Protein tyrosine phosphatase PTPRZ-B is a transmembrane signaling molecule that is found to be strongly up-regulated in glioma specimens. " 09/30/2014 - "Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility." 08/01/2014 - "Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility." 01/01/2013 - "Using mapping arrays to screen for genomic alterations in gliomas, we recently identified alterations of the protein tyrosine phosphatase receptor type kappa gene (PTPRK) that correlate to patient outcomes. " 12/01/2011 - "Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is an interaction partner of 14-3-3β, which correlates with the grade of malignancy in gliomas. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Protein-Tyrosine Kinases (Tyrosine Kinase)
3.	6-pyruvoyltetrahydropterin synthase (PTPS)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	bisperoxo(1,10- phenanthroline)oxovanadate(1- )
6.	Vanadium
7.	Potassium
8.	oxodiperoxo(pyridine- 2- carboxylate)vanadate(V)
9.	Protein Tyrosine Phosphatases
10.	protein-arginine deiminase

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Therapeutics
3.	Catheters
4.	Caloric Restriction
5.	Radiotherapy