Fungal Meningitis

01/01/2008 - "Fungal meningitis was suspected and treated with amphotericin B. "
04/01/1983 - "When fungal meningitis is present, a course of amphotericin B should be initiated and the CSF sterilized prior to the placement of the permanent extracranial shunt. "
09/01/2015 - "Fungal meningitis remains a severe and often lethal infection requiring aggressive antifungal therapy and in refractory cases the use of intrathecal amphotericin B (AmB). "
01/01/1983 - "It may be the drug of choice for Petriellidium boydii infections and it is an attractive alternative to amphotericin B for intrathecal administration to patients with fungal meningitis. "
01/01/2012 - "This trial compared the use of fluconazole versus amphotericin B (plus 5-fluorocytosine if fungal meningitis present). "

03/01/1988 - "Fluconazole holds promise as the sole or adjunctive therapy for fungal meningitis."
06/15/2002 - "Although fluconazole plays an integral role in treatment of fungal meningitis, its role in the treatment of histoplasmosis is hampered by reduced activity and potential development of resistance. "
01/27/1994 - "Fluconazole is useful in the common forms of fungal meningitis--namely, coccidioidal and cryptococcal meningitis. "
01/01/2012 - "This trial compared the use of fluconazole versus amphotericin B (plus 5-fluorocytosine if fungal meningitis present). "
01/01/2004 - "This study compared the use of fluconazole with amphotericin B (5-Fluorocytosine added if fungal meningitis present). "

09/01/1977 - "Miconazole appears promising as a treatment of fungal meningitis, but trials of longer duration might prevent relapse."
07/01/1978 - "Miconazole therapy for fungal meningitis."
09/01/1977 - "Twelve patients with fungal meningitis (ten cases were due to Coccidioides immitis, two were from Cryptococcus neoformans) were treated with brief courses of intravenous (IV) miconazole. "
09/01/1977 - "Treatment of fungal meningitis with miconazole."
07/01/1978 - "Miconazole is apparently an effective fungistatic drug of low toxicity and is a potentially useful agent in the treatment of systemic mycoses and fungal meningitis, in particular."

04/01/1995 - "We give an overview of the antifungal agents currently available for clinical use and their utility in the treatment of fungal meningitis."
05/01/2006 - "For the Finland lecture, I will briefly discuss the development of the Mycoses Study Group, provide an overview of the currently available antifungal agents, and describe advances and lessons related to the treatment and management of cryptococcal meningitis (the most common form of fungal meningitis), 3 important endemic mycoses (namely, blastomycosis, histoplasmosis, and coccidioidomycosis), candidemia and invasive candidiasis (the most common forms of nosocomial fungal disease), and invasive aspergillosis (the most common form of invasive mould disease). "
04/01/1995 - "Because of the problems associated with use of amphotericin B, newer azole antifungal agents have been developed, some of which are efficacious in the therapy of fungal meningitis. "

11/01/2011 - "In this study, we investigate whether Aspergillus or Candida DNA can be detected in cerebrospinal fluid (CSF) samples from patients suspected of fungal meningitis using real-time PCR assay. "

02/01/2015 - "Exserohilum rostratum caused a multistate fungal meningitis outbreak following iatrogenic inoculation of contaminated methylprednisolone in the United States. "
09/01/2013 - "The recent case reports of fungal meningitis after application of epidural methylprednisolone caused warning in the medical community. "
06/27/2013 - "Relapse of fungal meningitis associated with contaminated methylprednisolone."
04/01/2013 - "Multiple outbreaks have been linked to compounding pharmacies, including a recent outbreak of fungal meningitis related to contaminated methylprednisolone, exposing > 14,000 patients in multiple states. "
03/01/2013 - "A real-time PCR assay for rapid detection and quantification of Exserohilum rostratum, a causative pathogen of fungal meningitis associated with injection of contaminated methylprednisolone."

03/01/2015 - "We aimed to validate the diagnostic accuracy of CSF BDG measurements for fungal meningitis among patients exposed to contaminated methylprednisolone acetate (MPA). "
04/01/2013 - "outbreak of fungal meningitis related to contaminated methylprednisolone acetate. "
02/01/2015 - "Exserohilum rostratum was the major cause of the multistate outbreak of fungal meningitis linked to contaminated injections of methylprednisolone acetate produced by the New England Compounding Center. "
12/01/2013 - "The recent outbreak of fungal meningitis related to contaminated methylprednisolone acetate injections represents an important cause of morbidity and continues to be a significant public health problem in the United States. "
09/27/2013 - "On October 1, 2012, the Department of Defense (DoD) learned of a multistate outbreak of fungal meningitis in persons who received injections of methylprednisolone acetate (MPA) from a single compounding pharmacy. "

11/01/1987 - "In our institution, all 10 culturally proven cases of fungal meningitis, for which the lactic acid concentration in the CSF was available, were found to have an elevated lactic acid concentration (range 3.2 to 13.3 mmol per L vs normal range 0.8 to 2.8 mmol per L). "
11/01/1987 - "Use of cerebrospinal fluid lactic acid concentration in the diagnosis of fungal meningitis."
12/01/2001 - "The concentration of lactate in the CSF was elevated in the group of patients with bacterial meningitis (average = 46.2 mg/dL), fungal meningitis (average = 27.3 mg/dL) and in the AIDS group (average = 23.5 mg/dL). "
11/01/1987 - "This case prompted us to review the use of lactic acid as an indicator of fungal meningitis and compare it to other more commonly used nonspecific indicators of fungal meningitis, notably the concentrations of glucose and protein, and the number of leukocytes in CSF. "
09/01/2006 - "Pathological decrease of the CSF/serum glucose ratio or increased lactate concentration indicates bacterial or fungal meningitis or leptomeningeal metastases. "

01/01/2013 - "Epidural steroids recently attracted world attention due to medication contamination resulting in many cases of fungal meningitis. "
12/19/2012 - "Fungal meningitis from injection of contaminated steroids: a compounding problem."
01/01/2015 - "Neurological adverse events numbering 131, including 41 cases of arachnoiditis, have been identified by the FDA, and 700 cases of fungal meningitis following injection of contaminated steroids. "

01/01/2012 - " The examination of the cerebrospinal fluid showed the low glucose level, high mononuclear cell count, and highβ-D glucan level, the findings of which supported the diagnosis of fungal meningitis. "
11/01/1987 - "This case prompted us to review the use of lactic acid as an indicator of fungal meningitis and compare it to other more commonly used nonspecific indicators of fungal meningitis, notably the concentrations of glucose and protein, and the number of leukocytes in CSF. "
09/01/2006 - "Pathological decrease of the CSF/serum glucose ratio or increased lactate concentration indicates bacterial or fungal meningitis or leptomeningeal metastases. "

06/01/2015 - "Estimated deaths and illnesses averted during fungal meningitis outbreak associated with contaminated steroid injections, United States, 2012-2013."
03/01/2015 - "Our results suggest that CSF BDG measurements are highly sensitive and specific for the diagnosis of fungal meningitis associated with contaminated MPA injections. "
07/01/2014 - "In September 2012, a single case report sparked an investigation into a nationwide outbreak of fungal meningitis due to contaminated injectable drugs. "
12/01/2013 - "In 2012 the medical community in the United States faced an unprecedented outbreak of fungal meningitis caused by Exserohilum rostratum associated with injections of contaminated lots of methyprednilsone acetate. "
02/05/2013 - "Early clinical observations in prospectively followed patients with fungal meningitis related to contaminated epidural steroid injections."

07/01/2002 - "Among HIV negative subjects, ten cases of fungal meningitis (3 with Candida albicans and 7 with Cryptococcous neoformans) were noted at our end and nine of them had immunocompromised status (3 cases of renal transplant on immunosuppressives, 3 cases neonates/infant and 2 diabetic subjects. "
08/27/2003 - "Another patient died of fungal meningitis 10 days after transplantation with a functioning graft. "

05/01/2008 - "The authors discuss the challenges in diagnosing fungal meningitides and the risks of initiating HAART therapy in those with possible undiagnosed underlying opportunistic infections. "

03/01/1984 - "The identity of these critical structures and the histopathologic characteristics of bacterial labyrinthitis, fungal meningitis, syphilis of the inner ear, otosclerosis, presbycusis, genetically determined degenerations, trauma, intoxications, inflammatory, autoimmune and idiopathic disorders are presented in terms of their relevance for cochlear implantation."

08/27/2003 - "Another patient died of fungal meningitis 10 days after transplantation with a functioning graft. "