Bacterial Meningitis

03/01/2012 - "Is adjunctive dexamethasone beneficial in patients with bacterial meningitis?"
03/01/2002 - "It is concluded that dexamethasone may be beneficial in some aspects of bacterial meningitis, in adults. "
04/01/1997 - "So, the modulating effect of dexamethasone on both inflammatory and neuroendocrine response may be beneficial in bacterial meningitis and can probably be, achieved with sufficiently high dose of dexamethasone w has not yet been specified. "
12/01/2002 - "Apart from dexamethasone, these treatment strategies hold major promise for the adjunctive therapy of acute bacterial meningitis in clinical practice."
06/01/1997 - "Apart from dexamethasone these agents hold major promise for the adjunctive therapy of bacterial meningitis in clinical practice."

01/01/1991 - "The third generation cephalosporin ceftriaxone was found to be very safe and effective when administered intramuscularly once a day in the treatment of the different types of acute bacterial meningitis. "
06/28/1985 - "Seven days of ceftriaxone therapy is as effective as ten days' treatment for bacterial meningitis."
10/19/1984 - "The volume of distribution and the plasma clearance of ceftriaxone in pediatric patients were threefold greater than those in adults, and ceftriaxone penetrated the inflamed meninges of infants and children with bacterial meningitis. "
05/01/1988 - "Ceftriaxone is a safe and effective antibiotic for the treatment of bacterial meningitis when administered once daily."
05/01/1986 - "Based on this preliminary experience, ceftriaxone, when given in a single daily dose, appears safe and effective in the treatment of bacterial meningitis in nonneonatal infants and children."

01/01/1989 - "Although the development of antibiotics was the main contributing factor in improving the prognosis for bacterial meningitis, it is suggested from our data that other factors such as improved general supportive care and carrying out of public health programs also played an important role in improving the overall prognosis for bacterial meningitis."
01/01/2013 - "Despite the fact that the prognosis of bacterial meningitis has been improved by the influence of antibiotics, this disease is still one of the significant causes of morbidity and mortality in children. "
01/01/1986 - "Early administration of antibiotics proved particularly effective in preventing purulent bacterial meningitis of newborn; this disease did not occur with any of the infants observed during the study period. "
09/01/2015 - "Prompt administration of antibiotics, adjunctive steroid therapy, and optimization of antibiotic delivery to cerebrospinal fluid (CSF) are factors associated with improved outcome of patients hospitalized for acute bacterial meningitis (ABM). "
07/01/2012 - "Nowadays, with the use of antibiotics, bacterial meningitis can often be cured."

09/01/1984 - "The study demonstrates that cefotaxime is effective in the treatment of acute bacterial meningitis."
09/01/1989 - "Based on this clinical study, cefotaxime is an effective and safe drug for the treatment of childhood bacterial meningitis."
05/01/1995 - "Cefotaxime is an effective and safe drug for the treatment of childhood bacterial meningitis."
07/01/1985 - "Cefotaxime was found to be as safe and effective as standard therapy for the treatment of bacterial meningitis in children."
07/01/1986 - "We conclude that cefotaxime has similar efficacy when compared with conventional therapy for the management of bacterial meningitis in pediatric patients."

01/01/2007 - "Outcomes following bacterial meningitis are significantly improved by adjunctive treatment with corticosteroids. "
01/01/2007 - "Corticosteroids were protective against short-term neurological sequelae in patients with bacterial meningitis high-income countries (RR 0.56, 95% CI 0.3 to 0.84); in low-income countries this RR was 1.09 (95% CI 0.83 to 1.45). "
01/01/2003 - "Adjuvant corticosteroids are beneficial in the treatment of children with acute bacterial meningitis. "
05/01/2012 - "To evaluate the efficacy of the association of corticosteroids and the standard treatment of bacterial meningitis in pediatric patients. "
01/01/2015 - "All randomised controlled trials (RCTs) or quasi-RCTs of adjunctive corticosteroids for treatment of neonates with bacterial meningitis. "

07/01/2009 - "Several vaccines are available (including the Haemophilus influenzae type B polysaccharide conjugate vaccine) that have proven effective in reducing the incidence of bacterial meningitis. "
05/30/2012 - "We discuss how improved pathogen surveillance, implementation of current vaccines, and development of novel vaccines may be expected to further reduce bacterial meningitis and related diseases in the future."
08/01/2014 - "Since there is no nationwide mass immunization program for common agents of bacterial meningitis in Iran, the result of this study can be used to improve the existing vaccines to cover the detected serotypes and consequently reduce the incidence of bacterial meningitis."
08/01/2014 - "In the present study in addition of evaluation of common etiological agents (Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae) in bacterial meningitis cases, we sero-grouped or serotyped the obtained agents in order to predict the usefulness of existing vaccines against bacterial meningitis. "
06/01/2000 - "New vaccines are under study to further control bacterial meningitis."

01/01/1981 - "Is the CSF lactate measurement useful in the management of children with suspected bacterial meningitis?"
01/01/2013 - "Repeat Lumbar Puncture: CSF Lactic Acid Levels are Predictive of Cure with Acute Bacterial Meningitis."
09/01/1981 - "Use of CSF lactate measurement for monitoring the efficacy of treatment is illustrated in a case of bacterial meningitis due to Pseudomonas aeruginosa. "
10/01/2015 - "CSF lactate for accurate diagnosis of community-acquired bacterial meningitis."
01/01/2014 - "A CSF lactate cutoff point of 3.0 mmol/l had a sensitivity of 95% [95% confidence interval (CI) 83-99%), specificity of 94% (95% CI 90-96%) and negative predictive value of 99.3% (95% CI 97.7-99.9%) for bacterial meningitis. "

12/01/2002 - "Genetic targeting and/or pharmacologic blockade of the implicated pathways may be a future strategy for therapeutic adjunctive measures to improve outcome and may hold substantial promise, in concert with antimicrobial agents, in humans with acute bacterial meningitis."
12/01/1997 - "Safe and effective agents with demonstrated efficacy as adjuvants to bactericidal antimicrobial agents in the therapy for bacterial meningitis in humans may improve the prognosis of this disease."
11/01/1993 - "The judicious use of safe and effective agents with demonstrated efficacy as adjuncts to bactericidal antimicrobial agents in the therapy for bacterial meningitis in humans may improve the prognosis of this disease."
10/01/1996 - "The purpose of this study was to develop a model of bacterial meningitis in young adult rats for assessing the efficacy of antimicrobial agents. "
04/01/2005 - "These findings suggest that combination therapy with MEPM and various antimicrobial agents tested in this study are useful in treating bacterial meningitis caused by BLNAR and PRSP."

07/01/1982 - "We conclude that cefuroxime is effective and safe for the treatment of childhood bacterial meningitis caused by any of these common organisms."
01/01/1983 - "The efficacy of cefuroxime in the treatment of bacterial meningitis in infants and children."
07/01/1992 - "Initial therapy of bacterial meningitis with cefuroxime: Experience in 167 children."
09/01/1984 - "An extended experience with cefuroxime therapy of childhood bacterial meningitis."
02/01/1984 - "Cefuroxime treatment of bacterial meningitis in infants and children."

04/01/2011 - "We then did a randomised, double-blind, placebo-controlled trial of oral glycerol in adults with bacterial meningitis. "
04/01/2011 - "First, in an open-label dose-finding study, 45 adult patients with symptoms, signs, and cerebrospinal fluid findings consistent with bacterial meningitis received either 50 mL, 75 mL, or 100 mL of glycerol four times a day for 4 days. "
04/01/2011 - "Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial."
08/01/2012 - "Glycerol appears harmful in adults with acute bacterial meningitis. "
04/01/2011 - "Oral glycerol therapy cannot be recommended as an adjuvant therapy in adults with bacterial meningitis in resource-poor settings with a high HIV prevalence. "

12/17/2014 - "To evaluate the efficacy of intracranial pressure (ICP)-targeted treatment, compared to standard intensive care, in adults with community acquired acute bacterial meningitis (ABM) and severely impaired consciousness, a prospectively designed intervention-control comparison study was performed. "
01/01/2014 - "To evaluate the efficacy of early intracranial pressure (ICP)-targeted treatment, compared to standard intensive care, in adults with community acquired acute bacterial meningitis (ABM) and severely impaired consciousness. "
10/01/2007 - "The aim of this 4-year, observational, single-center study was to identify prognostic factors and evaluate the need for intensive care in cases of bacterial meningitis. "
04/01/2009 - "Despite progress in antibiotic therapy and intensive care, childhood bacterial meningitis (BM) remains a devastating disease. "
01/01/2005 - "Bacterial meningitis is a medical emergency and is optimally managed in an intensive care environment. "

03/01/1981 - "The present study, in which 59 of 97 children received chemotherapy for presumptive bacterial meningitis and of whom only 40 were subsequently proved to have a bacterial aetiology, reflects this. "
09/01/1953 - "A study of intrathecal chemotherapy in bacterial meningitis."
01/01/2015 - "In some developing countries, bacterial meningitis has appropriate clinical management and chemotherapy is available. "
06/01/2014 - "Bacterial meningitis after chemotherapy is rare, but this could be progress to a serious condition. "
06/01/2011 - "Bacterial meningitis is a serious problem in pediatric clinics and, therefore, needs urgent and empirical chemotherapy. "

12/01/1988 - "The range of pretreatment LZM levels in bacterial meningitis was 7.2 to 65 mg/l and above 3 mg/l in all cases 48 h after treatment. "
06/01/1991 - "After treatment, one patient developed bacterial meningitis, and two developed MTX-induced interstitial pneumonitis, which was cured by steroid therapy. "
01/01/2015 - "After treatment of postoperative bacterial meningitis, he was discharged on the 26(th) postoperative day in good condition without any neurologic deficit. "
06/01/2008 - "We report an 11-day-old full-term male neonate with persistent positive CRP after treatment of bacterial meningitis, and who developed hydrocephaly at follow-up. "
11/13/2001 - "Low cerebrospinal fluid beta-amyloid 42 in patients with acute bacterial meningitis and normalization after treatment."

09/28/1985 - "In children with bacterial meningitis chloramphenicol alone given by intramuscular injection is as effective as chloramphenicol plus penicillin given intravenously."
08/01/1994 - "Ceftriaxone therapy of bacterial meningitis: cerebrospinal fluid concentrations and bactericidal activity after intramuscular injection in children treated with dexamethasone."
09/28/1985 - "367 children with cerebrospinal-fluid findings suggestive of bacterial meningitis were randomised to receive either chloramphenicol alone by intramuscular injection, or chloramphenicol plus penicillin by intravenous injection. "
03/01/1980 - "One explanation for the failure of cephalothin to cure patients with bacterial meningitis is that desacetylcephalothin, as in vivo metabolite that has less antibacterial activity than the parent drug, penetrates more efficiently into cerebrospinal fluid (CSF); In experimental pneumococcal meningitis in rabbits, the peak levels of cephalothin and desacetylcephalothin in CSF after an intramuscular injection of 250 mg of cephalothin/kg were, respectively, 1.43 +/- 4.9 microgram/ml (2.8% of peak serum level) and 1.69 +/- 0.57 microgram/ml (2.2% of peak serum level). "
05/30/1981 - "Fifty children with bacterial meningitis were treated with intramuscular injections of benzyl penicillin, probenecid given orally and chloramphenicol palmitate suspension given orally, and the outcome was evaluated prospectively. "

01/01/2012 - "There are many potential etiologic factors potentially involved in postimplantation bacterial meningitis; although some can be managed or eliminated, vaccination against the most prevalent causal organism, the streptococcus pneumoniae, seems to be a powerful tool against this uncommon but serious complication of cochlear implantation. "
06/01/2013 - "The aim of this study was to analyze the audiophonological performance of children before and after cochlear implantation for SNHL following bacterial meningitis. "
05/01/2004 - "The histologic evidence presented in this study does not support open communication between the middle and the inner ear as part of the pathogenesis of bacterial meningitis as a late complication after cochlear implantation. "
10/01/2014 - "Bacterial meningitis is a rare yet potentially life-threatening complication of cochlear implantation. "
09/01/2014 - "Most cochlear abnormalities may be successfully treated with cochlear implantation, but the presence of a cochlear malformation may increase the risk for intraoperative cerebrospinal fluid leakage and postoperative bacterial meningitis. "