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Bacillary Angiomatosis

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A reactive vascular proliferation that is characterized by the multiple tumor-like lesions in skin, bone, brain, and other organs. Bacillary angiomatosis is caused by infection with gram-negative Bartonella bacilli (such as BARTONELLA HENSELAE), and is often seen in AIDS patients and other IMMUNOCOMPROMISED HOSTS.

Also Known As:

Angiomatosis, Bacillary; Angiomatosis, Bacillary Epithelioid; Angiomatoses, Bacillary; Angiomatoses, Bacillary Epithelioid; Angiomatoses, Epithelioid; Bacillary Angiomatoses; Bacillary Epithelioid Angiomatoses; Bacillary Epithelioid Angiomatosis; Epithelioid Angiomatoses; Epithelioid Angiomatoses, Bacillary; Epithelioid Angiomatosis; Epithelioid Angiomatosis, Bacillary; Angiomatosis, Epithelioid

Networked: 72 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Kaposi Sarcoma (Kaposi's Sarcoma)
2.	Infection
3.	Acquired Immunodeficiency Syndrome (AIDS)
4.	Cat-Scratch Disease
5.	Pyogenic Granuloma

Experts

1.	Kempf, Volkhard A J: 2 articles (01/2011 - 01/2005)
2.	Melter, Oto: 1 article (05/2015)
3.	Hruby, Miroslav: 1 article (05/2015)
4.	Sternbersky, Jan: 1 article (05/2015)
5.	Zamboch, Kamil: 1 article (05/2015)
6.	Flodr, Patrik: 1 article (05/2015)
7.	Orsag, Jiri: 1 article (05/2015)
8.	Klicova, Anna: 1 article (05/2015)
9.	Tkadlec, Jan: 1 article (05/2015)
10.	Zadrazil, Josef: 1 article (05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bacillary Angiomatosis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 06/01/2002 - "It is essential to recognize bacillary angiomatosis, as it can be cured with antibiotics." 09/01/2010 - "Bacillary angiomatosis can be treated with oral antibiotics." 01/01/1992 - "It is important to be able to diagnose bacillary angiomatosis correctly because prompt treatment with antibiotics is potentially life-saving." 01/01/1994 - "The usefulness of making such a diagnosis resides in the sensitivity of bacillary angiomatosis to antibiotics, emphasing the need to carefully look for the presence of bacterial clusters when atypical angioproliferative lesion appears in patients with AIDS." 10/01/1996 - "Accurate diagnosis of this infection is important because 1) bacillary angiomatosis is commonly mistaken for Kaposi sarcoma, 2) it is effectively treated with inexpensive antibiotics, and 3) undiagnosed and/or untreated bacillary angiomatosis may lead to overwhelming disseminated infection and death."
2.	Erythromycin (Erycette)FDA LinkGeneric 11/01/1989 - "With erythromycin therapy, the lesions of bacillary (epithelioid) angiomatosis cleared, while those of Kaposi's persisted. " 01/27/1999 - "The bacillary angiomatosis responded to 6 months of therapy with oral erythromycin." 06/01/1994 - "Caused by Rochalimaea henselae, bacillary angiomatosis is easily treated, when diagnosed early, with erythromycin. " 03/01/1990 - "Bacillary angiomatosis usually responds readily to treatment with oral erythromycin, 250 to 500 mg, taken four times a day for 2 weeks to 1 month. " 05/01/1989 - "Acquired immunodeficiency syndrome-related bacillary vascular proliferation (epithelioid angiomatosis): rapid response to erythromycin therapy."
3.	DNA (Deoxyribonucleic Acid)IBA 02/21/2013 - "In this work we develop an answer to this challenge by creating a multiplexed one-pot detection system for KSHV DNA and DNA from a frequently confounding disease, bacillary angiomatosis. " 12/01/1999 - "No case of bacillary angiomatosis harboured HHV-8 DNA. " 10/01/1999 - "Absence of Kaposi's sarcoma-associated herpesvirus DNA in bacillary angiomatosis-peliosis lesions." 09/01/1992 - "To further investigate the lesion, polymerase chain reaction DNA amplification and sequencing was performed, and the lesion was found to contain DNA sequences identical to those previously established for the agent of bacillary angiomatosis. " 12/01/1999 - "This finding might be useful in the distinction of bacillary angiomatosis from Kaposi's sarcoma, because lesions from patients with Kaposi's sarcoma almost always contains HHV-8 DNA."
4.	Clarithromycin (Biaxin)FDA LinkGeneric 09/01/1998 - "Clarithromycin therapy for bacillary peliosis did not prevent bacillary angiomatosis." 09/01/1993 - "The polyps were histologically typical for bacillary angiomatosis and complete symptomatic and radiographic response to oral clarithromycin was seen. " 06/15/1994 - "In AIDS, these compounds are indicated in mycobacteriosis (clarithromycin), bacillary angiomatosis and excavated pneumonia due to Rhodococcus equi. " 09/01/1993 - "The clinical presentation of bacillary angiomatosis includes pulmonary disease and in particular bronchial polyps; clarithromycin is an effective oral antibiotic." 11/01/2007 - "Treatment with clarithromycin resulted in resolution of the bacillary angiomatosis, fever, anemia, panserosites, and hepatitis."
5.	CollagenIBA 03/01/1998 - "Abundant FLS collagen was identified in close association with the organisms of bacillary angiomatosis in four cases; this morphologic alteration was seen in skin as well as lung and skeletal muscle. " 03/01/1998 - "Abundant FLS collagen was identified in 4 of 6 cases of bacillary angiomatosis, in close association with the organisms. " 03/01/1998 - "An association between FLS collagen and bacillary angiomatosis has not been previously described. " 03/01/1998 - "Fibrous long-spacing collagen in bacillary angiomatosis." 06/01/2010 - "In this model, Bartonella grows in extracellular aggregates, embedded within collagen matrix, similar to previous observations in cat scratch disease, bacillary peliosis, and bacillary angiomatosis. "
6.	Tufted angiomaIBA 01/01/2001 - "Tufted angioma has to be distinguished from Kaposi's sarcoma, angiosarcoma, hemangioma of infancy, sometimes bacillary angiomatosis and other cutaneous capillary malformations. " 01/01/1993 - "With this in mind, we wish to briefly review herein some of the more recently characterised dermal connective tissue lesions, including plexiform fibrohistiocytic tumour, cellular fibrous histiocytoma, spindle celled atypical fibroxanthoma, adult myofibroma, dermatomyofibroma, so-called cellular neurothekeoma, ectopic meningothelial hamartoma, tufted angioma, sinusoidal haemangioma and bacillary angiomatosis." 10/01/1994 - "These lesions include: bacillary angiomatosis, a vasoproliferative, pseudoneoplastic infection of immunocompromised patients caused by Rochalimaea henselae; tufted angioma, a variant of lobular capillary haemangioma characterised by a "cannon-ball" distribution of multiple lobules composed of packed capillaries and pericytes; microvenular haemangioma, a cutaneous haemangioma composed of thin-walled and irregularly branching blood vessels which dissect dermal collagen; sinusoidal haemangioma, a distinctive variant of cavernous haemangioma which may be located in the subcutaneous breast tissue and then may be confused with well-differentiated angiosarcoma; "hobnail haemangioma" (targetoid haemosiderotic haemangioma), a benign vascular tumour with a distinctive clinical targetoid appearance and a hobnail cytomorphology of the prominent endothelial tumour cells; retiform haemangioendothelioma, a very recently characterised low-grade angiosarcoma occurring most commonly in the extremities of adolescents which is characterised by arborising blood vessels arranged in a retiform pattern and lined by hobnail-like prominent endothelial cells; Kaposi-like infantile haemangioendothelioma, a borderline malignant tumour of infants mimicking Kaposi's sarcoma histologically; epithelioid angiosarcoma, a highly aggressive tumour in the spectrum of epithelioid vascular lesions which stains positively for endothelial and epithelial immunohistological markers; benign lymph-angioendothelioma (progressive lymphangioma), a benign, slowly growing macule or plaque which has to be distinguished from well-differentiated angiosarcoma and Kaposi's sarcoma; and lymphangiomatosis of the limbs, a poorly recognised angiomatosis occurring in young patients and limited mainly to the limbs with a favourable prognosis."
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/01/2005 - "Bartonella henselae causes the vasculoproliferative disorders bacillary angiomatosis and peliosis probably resulting from the release of vasculoendothelial growth factor (VEGF) from infected epithelial or monocytic host cells. " 01/01/2011 - " results may explain the decreased pathogenic potential of Bartonella henselae infection for cats as compared to humans and strongly suggest that an autocrine secretion of VEGF by human skin endothelial cells might induce their growth and ultimately lead to bacillary angiomatosis formation."
8.	Cyclosporine (Ciclosporin)FDA LinkGeneric 03/01/2008 - "Ciclosporin-induced fibrovascular polyps vs. bacillary angiomatosis." 06/01/2013 - "OKS needs to be distinguished clinically from other entities, including pyogenic granuloma, hemangioma, bacillary angiomatosis, and gingival enlargement caused by cyclosporine, a drug frequently used in recipients of organ transplantation. "
9.	Retinaldehyde (Retinal)IBA 06/01/1999 - "henselae infections is poorly delineated; unusual manifestations include conjunctival and retinal bacillary angiomatosis. " 07/01/1994 - "Rochalimaea henselae, a recently described pathogen thought to cause syndromes as varied as bacillary angiomatosis, parenchymal bacillary peliosis, fever with bacteremia, and cat-scratch disease, is associated with CNS diseases including cerebral and retinal bacillary angiomatosis, as well as cat-scratch-related encephalitis, myelitis, cerebral arteritis, and retinitis. "
10.	Hemin (Panhematin)FDA Link 02/01/2003 - "Bartonella quintana, the agent of trench fever and an etiologic agent of bacillary angiomatosis, has an extraordinarily high hemin requirement for growth compared to other bacterial pathogens. " 12/01/2000 - "Bartonella quintana, the agent of trench fever and a cause of endocarditis and bacillary angiomatosis in humans, has the highest reported in vitro hemin requirement for any bacterium. "

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 05/01/2015 - "We report the first case of cutaneous bacillary angiomatosis due to Bartonella quintana in renal transplant recipient. " 05/01/2015 - "Cutaneous bacillary angiomatosis due to Bartonella quintana in a renal transplant recipient." 08/01/2012 - "Cutaneous bacillary angiomatosis in renal transplant recipients: report of three new cases and literature review." 01/01/2007 - "High suspicion of bacillary angiomatosis in a kidney transplant recipient: a difficult way to diagnose--case report." 01/01/2004 - "Bacillary angiomatosis of the lymph node in the renal transplant recipient."
2.	Drug Therapy (Chemotherapy) 01/01/2011 - "Refractory Bartonella quintana bacillary angiomatosis following chemotherapy for chronic lymphocytic leukaemia." 10/01/1992 - "Bacillary angiomatosis in a child undergoing chemotherapy." 10/01/1993 - "This is the first case report detailing the features of bacillary angiomatosis of the spleen occurring in a patient undergoing cytotoxic chemotherapy for disseminated ovarian carcinoma." 10/01/1992 - "We report a case of bacillary angiomatosis in a child undergoing chemotherapy for acute leukemia." 01/01/2011 - "quintana bacillary angiomatosis following fludarabine-based chemotherapy for chronic lymphocytic leukaemia that was refractory to standard treatment and was complicated by lymphadenopathy and osteomyelitis."
3.	Highly Active Antiretroviral Therapy (HAART) 01/01/2012 - "Information is limited on the evolution of bacillary angiomatosis during immune restoration following initiation of HAART. "
4.	Organ Transplantation 06/01/2013 - "OKS needs to be distinguished clinically from other entities, including pyogenic granuloma, hemangioma, bacillary angiomatosis, and gingival enlargement caused by cyclosporine, a drug frequently used in recipients of organ transplantation. "
5.	Autologous Transplantation 08/01/2010 - "Bacillary angiomatosis after skin autografting in a patient without human immunodeficiency virus who was treated with interferon alfa."