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Levonorgestrel (Plan B)

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A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.

Also Known As:

Plan B; Mirena; Norplant; Alcala Brand of Levonorgestrel; Aventis Pharma Brand of Levonorgestrel; Berlex Brand of Levonorgestrel; Capronor; Cerazet; D-Norgestrel; HRA Brand 1 of Levonorgestrel; HRA Brand 2 of Levonorgestrel; Hexal Brand of Levonorgestrel; Microlut; Microval; NorLevo; Norgeston; Norplant-2; Paladin Brand of Levonorgestrel; Schering Brand 1 of Levonorgestrel; Schering Brand 2 of Levonorgestrel; Schering Brand 3 of Levonorgestrel; Vikela; Women's Capital Brand of Levonorgestrel; Wyeth Brand of Levonorgestrel; duofem; D Norgestrel; Levonorgestrel Alcala Brand; Levonorgestrel Berlex Brand; Levonorgestrel Hexal Brand; Levonorgestrel Paladin Brand; Levonorgestrel Wyeth Brand; Norplant 2; Norplant2; l Norgestrel; l-Norgestrel; 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)-

Networked: 1260 relevant articles (143 outcomes, 274 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Norsteroids: 12
    - Norpregnanes: 1
      - Norpregnenes
        Norgestrel: 82
        Levonorgestrel: 1260
        levonorgestrel drug combination ethinyl estradiol: 5
        klimonorm: 2
        levonorgestrel oxime: 2
        SHD 386L: 1
        levonorgestrel-4 beta,5 beta-epoxide
        lybrel

Experts

1.	Bahamondes, Luis: 17 articles (09/2015 - 01/2002)
2.	Hurskainen, Ritva: 12 articles (08/2014 - 01/2003)
3.	Paavonen, Jorma: 11 articles (08/2014 - 01/2003)
4.	Inki, Pirjo: 10 articles (03/2015 - 10/2005)
5.	Grimes, David A: 10 articles (01/2013 - 02/2002)
6.	Seong, Seok Ju: 9 articles (10/2015 - 06/2010)
7.	Wildemeersch, D: 9 articles (01/2010 - 12/2000)
8.	Gupta, Janesh K: 8 articles (10/2015 - 08/2008)
9.	Kaunitz, Andrew M: 8 articles (05/2015 - 03/2007)
10.	Helmerhorst, Frans M: 8 articles (01/2015 - 05/2002)

Related Diseases

1.	Menorrhagia 06/01/2001 - "The FibroPlant levonorgestrel IUS is effective in significantly reducing the amount of menstrual blood loss in women with menorrhagia. " 01/01/2013 - "The aim of the present study was to identify variables associated with treatment failure in women with menorrhagia who were treated with thermal balloon ablation (TBA) or levonorgestrel releasing intrauterine system (LNG-IUS), and to determine if there are subgroups where one treatment type is more effective than the other. " 01/01/2012 - "The levonorgestrel-releasing intrauterine system is an effective treatment for menorrhagia. " 06/01/2007 - "Use of levonorgestrel-releasing system provides both contraceptive and therapeutic effects in the treatment of menorrhagia." 01/01/2007 - "It has been shown that levonorgestrel-releasing intrauterine system (LNG-IUS) is an effective treatment of menorrhagia. "
2.	Hemorrhage 12/01/2000 - "The FibroPlant levonorgestrel intrauterine system is also highly efficacious in controlling bleeding in women presenting with excessive menstrual flow. " 08/01/2000 - "Norplant users with BTB problems also had a non-significant reduction in level 2 vessels compared to women without bleeding problems (4 +/- 2 versus 11 +/- 4%, P = 0.0667). " 02/01/1997 - "The efficacy of the progestin therapy was evaluated by transvaginal ultrasonography and by examination of endometrial biopsy samples taken 20 months (mean, range 17 - 22; first evaluation) and 34 months (mean, range 31 - 38 months; second evaluation) after insertion of the levonorgestrel-releasing intrauterine system, and by studying patterns of bleeding. " 03/01/1995 - "In Norplant-II implants users, 75 to 80% of women had irregularities in bleeding pattern during the first year of use which improved with prolonged use. " 09/01/2014 - "The aim of our study was to examine the effect of the levonorgestrel-releasing intrauterine system (LNG-IUS) treatment on depressive symptoms, changes in bleeding patterns, and quality of life (QoL) among premenopausal women in our clinic. "
3.	Endometriosis (Adenomyosis) 12/01/2015 - "The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective for the medical treatment of adenomyosis. " 07/01/2011 - "The levonorgestrel (LNG) intrauterine system (LNG-IUS) has been shown to improve symptoms in women with minimal to moderate endometriosis. " 12/01/2006 - "To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis. " 08/01/2005 - "To assess the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis. " 12/01/2006 - "[Clinical study of levonorgestrel-releasing intrauterine system for adenomyosis]."
4.	Endometrial Hyperplasia 09/01/2008 - "The levonorgestrel-releasing intrauterine system seems to be an effective and safe alternative in the treatment of peri- and postmenopausal women with (simple) endometrial hyperplasia without atypia." 06/01/2015 - "Efficacy of the Levonorgestrel-Releasing Intrauterine System on IVF-ET Outcomes in PCOS With Simple Endometrial Hyperplasia." 01/01/2013 - "Randomised controlled trials (RCTs) of the levonorgestrel-releasing intrauterine system (LNG-IUS) versus progestin therapy in women with a confirmed histological diagnosis of simple or complex endometrial hyperplasia with atypia. " 11/01/2012 - "Observational studies suggested that levonorgestrel-releasing intrauterine system (LNG-IUS) has been successfully used to treat endometrial hyperplasia without cytological atypia and selected cases of atypical endometrial hyperplasia. " 11/01/2011 - "The objective of this study was to evaluate the potential treatment of atypical and non-atypical endometrial hyperplasia with the levonorgestrel intrauterine system (LNG-IUS). "
5.	Acne Vulgaris 01/01/2012 - "A levonorgestrel-COC group had fewer total lesion counts (MD -9.98; 95% CI -16.51 to -3.45), inflammatory and non-inflammatory lesion counts, and were more likely to have a clinician assessment of clear or almost clear lesions and participant self-assessment of improved acne lesions. " 01/01/2012 - "A levonorgestrel-COC group had fewer total lesion counts (MD -9.98; 95% CI -16.51 to -3.45), inflammatory and non-inflammatory lesion counts, and were more likely to have a clinician assessment of clear or almost clear lesions and participant self-assessment of improved acne lesions. " 11/01/1991 - " It is not known whether the woman's acne improved since Norplant removal. " 09/06/2011 - "EE/CMA was better than placebo and similar to another low-dose oral contraceptive (ethinylestradiol/levonorgestrel) in improving symptoms of acne in two phase III randomized controlled trials in patients with mild to moderate papulopustular acne. " 08/01/2008 - "Levonorgestrel-releasing intrauterine system and new-onset acne."

Related Drugs and Biologics

1.	Levonorgestrel (Plan B)
2.	Ethinyl Estradiol (Estinyl)
3.	Progestins (Progestagens)
4.	Gonadotropin-Releasing Hormone (GnRH)
5.	Cyproterone Acetate
6.	Chlormadinone Acetate (Chlormadinone)
7.	Copper
8.	Tranexamic Acid (AMCA)
9.	Medroxyprogesterone Acetate (Depo-Provera)
10.	Hormones

Related Therapies and Procedures

1.	Intrauterine Devices (Intrauterine Device)
2.	Contraception (Birth Control)
3.	Endometrial Ablation Techniques
4.	Hysterectomy
5.	Injections