Interleukin-9 (Interleukin 9)

A multifunctional cytokine secreted by primarily by activated TH2 CELLS that may play a role as a regulator of allergic INFLAMMATION. It has been shown to enhance the growth and CELL DIFFERENTIATION of MAST CELLS, and can act on a variety of other immune cells.

Also Known As:

Networked: 404 relevant articles (7 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Renauld, Jean-Christophe: 14 articles (12/2013 - 11/2002)
2.	Renauld, J C: 13 articles (11/2002 - 01/2000)
3.	Hamid, Qutayba: 9 articles (11/2007 - 02/2002)
4.	Van Snick, J: 9 articles (01/2007 - 01/2000)
5.	Van Snick, Jacques: 8 articles (12/2011 - 11/2002)
6.	McKenzie, Andrew N J: 7 articles (07/2014 - 07/2002)
7.	Levitt, Roy C: 7 articles (03/2007 - 01/2002)
8.	Levitt, R C: 7 articles (06/2004 - 01/2000)
9.	Kaplan, Mark H: 6 articles (08/2015 - 08/2009)
10.	Wang, Xin: 6 articles (01/2014 - 12/2011)

Related Diseases

1.	Asthma (Bronchial Asthma) 03/15/2012 - "The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma." 10/01/2015 - "IL9 polymorphisms (rs11741137, rs2069885, and rs1859430) showed evidence for interaction with dust mite in the Childhood Asthma Management Program (P = .02 to .03), with replication in the Genetics of Asthma in Costa Rica Study (P = .04). " 04/01/2015 - "This study shows for the first time that IL-9 is involved in EO homeostasis in CRSwNP and could explain the low benefit of anti-IL-5 therapy for some patients with asthma and nasal polyposis." 09/01/2013 - "In this study, we demonstrated that Smad2 and Smad3 are necessary for IL-9 production from T cells in an OVA-induced asthma model using T cell-specific Smad2- and Smad3-deficient mice. " 06/01/2009 - "Genetic studies have shown linkages for asthma to the chromosomal region 5q31-q33 in humans that includes the IL-9 gene. "
2.	Bronchiolitis 03/27/2004 - "Median interleukin 9 protein concentration on day 1 (1.9 microg/L [range 0.1-36.2]) was significantly greater in term infants with bronchiolitis than either preterm infants (0.4 microg/L [0.1-2.9]; p<0.05) or the control group (0.7 microg/L [0.4-2.5]; p<0.05). " 06/01/2010 - "Although so far a difference in IL-9 production in boys and girls has not been reported, this study may help in explaining the different risks of severe RSV bronchiolitis in boys and girls." 06/01/2010 - "In conclusion, the IL-9 genetic polymorphism (rs2069885) has an opposite effect on the risk of severe RSV bronchiolitis in boys and girls. " 06/01/2010 - "Haplotype analysis of two SNPs in the IL-9 gene (rs2069885 and rs1799962) showed overrepresentation of the TT haplotype in girls with severe RSV bronchiolitis requiring hospitalization indicating that this is the haplotype conferring the highest risk in girls. " 12/01/2009 - "High levels of IL-9 are present in bronchial secretions from infants with respiratory syncytial virus (RSV) bronchiolitis. "
3.	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 11/01/2014 - "Neutralization of interleukin-9 ameliorates symptoms of experimental autoimmune myasthenia gravis in rats by decreasing effector T cells and altering humoral responses." 11/01/2014 - "The aim of this study was to determine whether IL-9 and Th9 cells promote the progression of experimental autoimmune myasthenia gravis (EAMG). "
4.	Leukemia 11/01/2002 - "An alternate protocol is based on the ability of IL-9 to stimulate the proliferation of the human megakaryoblastic leukemia cell line, M-O7e. " 09/15/2000 - "We then examined the role of IL-9 in eosinophil differentiation using the human cord blood CD34(+) cells and human promyelocytic leukemia cells (HL-60). " 01/01/2014 - "Recently, the oncogenic activities of IL-9 were reported in some leukemia but not chronic lymphocytic leukemia (CLL). " 08/01/2012 - "Over-expression of the receptor of IL-9 (IL-9R) occurs in several types of human leukemias and in radiation-induced mouse T-cell lymphoma (TL). " 12/01/2005 - "Furthermore, IL-9 was specifically expressed by SNK-6 and SNT-8 cells but not by other NK-cell, NK-like T-cell, and T-cell lymphoma/leukemia cell lines. "
5.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/01/2010 - "Neutralization of IL-9 ameliorates experimental autoimmune encephalomyelitis by decreasing the effector T cell population." 07/01/2014 - "In experimental autoimmune encephalomyelitis, forced expression of BCL6 in myelin oligodendrocyte glycoprotein35-55-specific Th9 cells resulted in decreased IL-9 production and induction of IFN-γ, causing an exacerbation of the clinical disease. " 08/04/2009 - "Interestingly, IL-9 enhances the suppressive functions of FoxP3(+) CD4(+) T(reg) cells in vitro, and absence of IL-9 signaling weakens the suppressive activity of nT(regs) in vivo, leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis. " 08/03/2009 - "To determine if IL-9 has functional consequences in Th17-mediated inflammatory disease, we evaluated the role of IL-9 in the development and progression of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. " 12/01/2015 - "Interleukin (IL) 9, a dominant cytokine in Th9 cells, has been proven to play a pathogenic role in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), by augmenting T cell activation and differentiation; however, whether IL-9 signaling affects central nervous system (CNS)-resident cells during CNS autoimmunity remains unknown. "

Related Drugs and Biologics

1.	Interleukin-13
2.	Cytokines
3.	Interleukins
4.	Dinoprostone (PGE2)
5.	Erythropoietin
6.	Interleukin-5 (Interleukin 5)
7.	Interleukin-4 (Interleukin 4)
8.	Interleukin-9 (Interleukin 9)
9.	Interleukin-17 (Interleukin 27)
10.	Immunoglobulin E (IgE)

Related Therapies and Procedures

1.	Immunotherapy
2.	Injections
3.	Transplants (Transplant)
4.	Aftercare (After-Treatment)
5.	Immunomodulation