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Interferon-beta

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One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.

Also Known As:

Fiblaferon; Interferon, beta; Interferon, beta-1; Interferon-beta1; beta-1 Interferon; Fibroblast Interferon; Interferon beta; Interferon beta1; Interferon, beta 1; beta 1 Interferon; beta Interferon; Interferon, Fibroblast; beta-Interferon

Networked: 2597 relevant articles (207 outcomes, 361 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hartung, Hans-Peter: 25 articles (08/2013 - 06/2003)
2.	Montalban, Xavier: 19 articles (11/2015 - 09/2002)
3.	Yoshida, Jun: 18 articles (01/2009 - 02/2002)
4.	Pozzilli, Carlo: 16 articles (11/2015 - 01/2002)
5.	Comabella, Manuel: 15 articles (11/2015 - 05/2002)
6.	Comi, Giancarlo: 15 articles (11/2015 - 05/2005)
7.	Bertolotto, Antonio: 14 articles (11/2015 - 01/2004)
8.	Oger, Joel: 14 articles (05/2015 - 08/2003)
9.	Mizuno, Masaaki: 14 articles (12/2008 - 02/2002)
10.	Río, Jordi: 13 articles (11/2015 - 10/2002)

Related Diseases

1.	Multiple Sclerosis 01/01/2010 - "Interferon beta is beneficial in multiple sclerosis; why so remains unclear. " 06/01/2003 - "Although interferon-beta (IFN-beta) has been demonstrated to be effective in the treatment of multiple sclerosis (MS) patients, the mechanism(s) underlying its beneficial effects has not been uncovered yet. " 11/27/1981 - "Ten patients with multiple sclerosis who were treated with human fibroblast interferon (IFN-B) for 6 months showed a significant reduction in their exacerbation rates compared with their rates before treatment (P < .01). " 07/01/2008 - "Several large clinical trials have demonstrated that interferon-beta (IFN-beta) therapy is effective in the treatment of multiple sclerosis (MS) patients. " 12/20/1986 - "In this randomised, double-blind, placebo-controlled, 2-year multicentre study intrathecally administered natural human fibroblast interferon (IFN-B) was effective in reducing exacerbations of multiple sclerosis (MS) in patients with exacerbating/remitting disease. "
2.	Relapsing-Remitting Multiple Sclerosis 10/01/2001 - "Interferon-beta (IFN-beta) has been used successfully to treat patients with relapsing-remitting multiple sclerosis (MS). " 07/01/2011 - "In the absence of a better alternative, subcutaneous interferon beta is the standard first-line treatment for relapsing-remitting multiple sclerosis. " 06/01/2009 - "Treatment of relapsing-remitting multiple sclerosis with interferon beta is only partly effective, and new more effective and safe strategies are needed. " 01/01/1996 - "The results of two phase III clinical trials have recently shown that interferon-beta (IFNbeta) is effective in the treatment of relapsing-remitting multiple sclerosis (RRMS). " 05/15/2011 - "Interferon beta is widely used as first-line treatment for relapsing remitting multiple sclerosis (RRMS). "
3.	Infection 11/01/2002 - "In patients with hepatitis C virus infection interferon-beta therapy is most effective when administered by the intravenous route. " 09/01/1989 - "The most effective treatment of chronic HBV-infection today is the therapy with alpha- or beta-interferon. " 03/01/1988 - "Recombinant murine beta interferon was protective and therapeutic for mice against Listeria monocytogenes infection in vivo. " 08/15/2003 - "A study was undertaken to evaluate the efficacy of an adenoviral construct expressing the murine interferon-beta (IFN-beta) transgene (Ad:IFN-beta) against herpes simplex virus type 1 (HSV-1) infection in a primary trigeminal ganglion (TG) cell culture. " 08/01/2002 - "A study was undertaken to evaluate the efficacy of an adenoviral vector containing the murine interferon-beta (IFN-beta) transgene (Ad:IFN-beta) against herpes simplex virus type 1 (HSV-1) infection in two transduced cell lines. "
4.	Chronic Hepatitis C 07/01/2000 - "Several pretreatment factors have been reported to be useful in predicting patients with a high probability for a sustained response to IFN-alpha treatment, however, predictors of the efficacy of interferon-beta treatment in chronic hepatitis C have not been fully assessed. " 04/01/1998 - "However, due to the high cost of beta interferon, this high-dose schedule would probably not be cost-effective in the treatment of chronic hepatitis C." 05/01/2003 - "The intravenous administration of interferon-beta may be effective for the treatment of chronic hepatitis C, as is intramuscular interferon-beta. " 04/01/1998 - "The intramuscular use of beta interferon has been tested in the treatment of chronic hepatitis C, but it did not prove effective when the schedule was 3 million units three times a week for six months. " 01/01/2008 - "The efficacy of short-term interferon-beta therapy for chronic hepatitis C patients with low virus load."
5.	Neoplasms (Cancer) 01/01/2004 - "Our goals were to determine the mechanisms responsible for this loss of efficacy and to test the hypothesis that the combination of preoperative adenovirus encoding interferon-beta and surgical resection would be effective in treating bulky tumors. " 11/01/2008 - "We have shown that continuous systemic delivery of interferon beta (IFN-beta) remodels dysfunctional tumor vasculature, thereby improving tumor perfusion and enhancing delivery and efficacy of chemotherapeutic drugs. " 02/01/2006 - "The purpose of this study was to investigate the therapeutic potential of interferon-beta (IFN-beta) against tumors that resist its antiproliferative effects. " 07/01/2004 - "In this study, we constructed a novel adeno-associated virus (AAV) vector containing the human interferon-beta (hIFN-beta) gene under the control of hTERT promoter (AAV-hTERT-hIFN-beta) and investigated its antitumor effect against various human cancer cells in vitro. " 09/01/2002 - "In previous studies interferon-beta (IFNbeta) has been shown to suppress tumor growth. "

Related Drugs and Biologics

1.	copolymer 1 (glatiramer acetate)
2.	Neutralizing Antibodies
3.	Interferon-alpha (Interferon Alfa)
4.	Interferons
5.	natalizumab (Tysabri)
6.	Azathioprine (Imuran)
7.	DNA (Deoxyribonucleic Acid)
8.	Antibodies
9.	Cytokines
10.	Nimustine

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Subcutaneous Injections
5.	Immunomodulation