Angiodysplasia

Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA.

Also Known As:

Networked: 323 relevant articles (36 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	von Willebrand Diseases (von Willebrand's Disease)
3.	Vascular Malformations
4.	Gastrointestinal Hemorrhage (Hematochezia)
5.	Gastric Antral Vascular Ectasia (Watermelon Stomach)

Experts

1.	Sapelkin, S V: 4 articles (01/2015 - 01/2007)
2.	Dan, V N: 4 articles (01/2015 - 01/2007)
3.	Junquera, Félix: 3 articles (02/2007 - 08/2003)
4.	McNamara, Deirdre: 2 articles (11/2015 - 10/2010)
5.	Xiao, Shudong: 2 articles (12/2014 - 06/2012)
6.	Gao, Yunjie: 2 articles (12/2014 - 06/2012)
7.	Fang, Jingyuan: 2 articles (12/2014 - 06/2012)
8.	Ge, Zhizheng: 2 articles (12/2014 - 06/2012)
9.	Shchegolev, A I: 2 articles (02/2011 - 01/2009)
10.	Pavlov, K A: 2 articles (02/2011 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Angiodysplasia:

1.	Octreotide (Sandostatin)FDA LinkGeneric 01/01/2008 - "Although octreotide treatment seems to be beneficial in reducing the blood loss from angiodysplasias, controlled studies to determine its optimal use are awaited. " 02/01/2007 - "This study suggests that octreotide treatment may be beneficial in preventing rebleeding from gastrointestinal angiodysplasia." 09/15/2007 - "Octreotide has shown to be effective against rebleeding from gastrointestinal angiodysplasias, but a long-term daily parenteral administration is recommended. " 05/01/2001 - "Long-acting octreotide is effective in controlling rebleeding angiodysplasia of the gastrointestinal tract." 01/01/2011 - "The authors conclude that octreotide is safe and effective in gastrointestinal angiodysplasias inaccessible to endoscopy or surgery."
2.	Estrogens (Estrogen)FDA Link 11/01/2001 - "We investigated the efficacy of long-term estrogen-progestagen therapy in the prevention of rebleeding from gastrointestinal angiodysplasia. " 11/01/2001 - "Continuous estrogen-progestagen treatment is not useful in the prevention of rebleeding from gastrointestinal angiodysplasia." 05/01/1988 - "A therapeutic trial of conjugated estrogen should be considered in patients with recurrent gastrointestinal bleeding secondary to gastrointestinal angiodysplasia after the use of therapeutic endoscopy and/or surgery. " 11/01/1994 - "It has been suggested that estrogen-progestagen therapy may be useful in preventing bleeding from gastric angiodysplasia, a vascular lesion similar to that described in portal-hypertensive gastropathy. " 05/01/1987 - "Septal dermoplasty and oral estrogens may allow prolonged remission of epistaxis, but permanent surgical cure of gastrointestinal bleeding is rarely feasible because of diffuse angiodysplasia of the alimentary tract. "
3.	Thalidomide (Thalomid)FDA Link 12/01/2014 - "Thalidomide is effective in the treatment of angiodysplasia. " 06/01/2012 - "Thalidomide was reported to be effective in the treatment of angiodysplasia, but the mechanisms underlying its activity are, as yet, unknown. " 07/01/2015 - "The aim of this study was to present a new case on the successful use of thalidomide in a patient with acquired von Willebrand syndrome and recurrent angiodysplasia-related GI bleedings, and to conduct a literature review on the use of thalidomide in patients with GI angiodysplasia. " 12/01/2014 - "The aim of this study was to explore the expression and effects of Robo1 and Slit2 in angiodysplasia and to identify the possible therapeutic mechanisms of thalidomide. " 07/01/2015 - "Thalidomide for treatment of gastrointestinal bleedings due to angiodysplasia: a case report in acquired von Willebrand syndrome and review of the literature."
4.	ArgonIBA 07/01/2010 - "Endoscopic argon plasma ablation therapy is a new, effective and safe treatment in the management of gastrointestinal angiodysplasia. " 10/01/2007 - "[Duodenal angiodysplasia perforation after argon plasma therapy; solved with endoclips]." 03/26/1999 - "Argon-plasma laser coagulation (APC) for the angiodysplasia was performed twice. " 12/01/2003 - "Another patient with evidence of angiodysplasia and bleeding was effectively treated with Argon-beam during enteroscopy. " 10/01/2006 - "Endoscopic argon plasma ablation therapy is useful in the management of bleeding from colonic angiodysplasia."
5.	ProgesteroneFDA LinkGeneric 07/01/1993 - "Oestrogen-progesterone may be a valuable alternative therapy in elderly patients with repeated bleeding, despite endoscopic coagulation, secondary to gastrointestinal angiodysplasia which cannot be treated surgically, in patients who deny surgery, or with rebleeding after surgery." 07/01/1993 - "A 75-year-old man with angiodysplasia of the sigmoid and rectum and recurrent lower gastrointestinal bleeding episodes, despite repeated endoscopic laser-coagulation, was successfully treated with oestrogen-progesterone. " 01/01/2005 - "Judicious usage of estrogen/progesterone for angiodysplasia." 01/29/2000 - "[Severe gastrointestinal hemorrhage secondary to diffuse angiodysplasia: efficacy of estrogen-progesterone treatment]." 05/01/1988 - " In patients with gastrointestinal angiodysplasia who have cryptogenic gastrointestinal bleeding, despite the use of therapeutic endoscopy and surgery, possibly a trial of estrogen-progesterone therapy should be considered."
6.	von Willebrand FactorIBA 08/01/2015 - "Could a Transient Deficiency in Von Willebrand Factor Be a Cause of Gastrointestinal Angiodysplasia?" 01/01/2013 - "Von Willebrand factor, angiodysplasia and angiogenesis." 02/01/2005 - "Mean plasma von Willebrand factor levels were higher in angiodysplasia patients (208+/-12%) than in controls (143+/-11%) (P<0.05). " 06/01/1999 - "[Acquired deficiency of von Willebrand factor (wWF) associated with intestinal angiodysplasia. " 12/01/1996 - "The development of gastrointestinal angiodysplasia may not only be associated with a dysfunction of von Willebrand factor but also with that of platelets."
7.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 07/01/2003 - "Somatostatin therapy ameliorates chronic and refractory gastrointestinal bleeding caused by diffuse angiodysplasia in a patient on anticoagulation therapy." 01/01/2015 - "Despite the lack of double-blinded randomized placebo-control trials and despite the limitations of the available evidence in the literature, including small sample size, variable dosing, and administration routes, there is a consistent agreement in the literature that somatostatin analogs are a safe, well-tolerated, and effective therapeutic option for managing refractory or occult bleeding from the lower digestive tract, with particular reference to patients with angiodysplasia, where endoscopic or surgical management is either not feasible or unsuccessful and other pharmacological options are not preferred. " 09/01/2012 - "Long-acting somatostatin analogues may represent an option for the management of patients with chronic bleeding due to gastrointestinal angiodysplasias." 09/01/2012 - "Long-acting somatostatin analogues treatment decreased transfusion needs in patients with refractory bleeding from gastrointestinal angiodysplasias. " 03/10/2008 - "The case illustrates the usefulness of somatostatin analogues in the treatment of bleeding GI-angiodysplasias."
8.	Progestins (Progestagens)IBA 02/01/1995 - "The efficacy of an association of estrogens and progestagens in the treatment of gastrointestinal bleeding by angiodysplasia was analyzed. " 02/01/1995 - "In conclusion, the combined treatment with estrogens and progestagens prevents recurrence of gastrointestinal bleeding by angiodysplasia." 01/01/1993 - "[Efficacy of estrogens and progestational hormones in persistent hemorrhagic recurrences in digestive angiodysplasia after discontinuation of hormone therapy]."
9.	Carbon MonoxideIBA 09/01/2009 - "Increasing age, anti-coagulation and liver co-morbidity are significant predictors of a positive diagnostic yield whilst the presence of co-morbidity or a diagnosis of angiodysplasia may predict a change in management." 09/01/2009 - "Factors which predicted a change in management included the presence of co-morbidity (p=0.02) and having a diagnosis of angiodysplasia on CE (p=0.001). " 01/01/2012 - "More GAVE patients than angiodysplasia patients had co-existing liver cirrhosis (63.2% versus 25.9%, P = 0.012). " 09/01/2005 - "Co-existence of true colonic diverticula with angiodysplasia." 01/01/2010 - "Aortic valve replacement is the first line therapy for advanced stage AS-patients, but can also be an effective treatment for co-existent bleeding angiodysplasias and acquired von Willebrand disease. "
10.	HormonesIBA 10/19/2002 - "Avoid hormones in gastrointestinal angiodysplasia." 06/01/1993 - "Patients with bleeding angiodysplasia are occasionally treated with hormones or, more often, by endoscopic methods. " 01/01/1993 - "[Efficacy of estrogens and progestational hormones in persistent hemorrhagic recurrences in digestive angiodysplasia after discontinuation of hormone therapy]."

Therapies and Procedures

1.	Argon Plasma Coagulation 03/01/2012 - "The most frequently applied methods of endoscopic treatment of angiodysplasias, such as argon plasma coagulation, multipolar coagulation and heater probe, proved to be effective with certain shortcomings and the possibility of complications. " 01/01/2003 - "Argon plasma coagulation is an effective treatment for gastric angiodysplasia in patients on dialysis." 02/01/2013 - "The angiodysplasias were treated with argon plasma coagulation. " 01/01/2013 - "Combined endoclipping and argon plasma coagulation (APC)--daisy technique for cecal angiodysplasia." 08/01/2007 - "DBE was also used to successfully treat three cases of angiodysplasia with argon plasma coagulation. "
2.	Ligation 03/01/2012 - "Endoscopic ligation with elastic rings can be effective and safe for treatment especially of solitary gastric and duodenal angiodysplasias." 03/01/2012 - "The aim of the study was to examine the efficacy and safety of endoscopic treatment of gastric and duodenal angiodysplasias by ligation with elastic rings. " 03/01/2004 - "This study evaluated the treatment of gastroduodenal angiodysplasia by detachable mini-loop ligation. " 03/01/2012 - "There were no complications after ligation of angiodysplasias. " 03/01/2012 - "Patients were under follow-up after 2-3 days, 30 days and then every 6 months following the endoscopic ligation of angiodysplasias. "
3.	Electrocoagulation (Electrocautery) 10/01/1989 - "To study the natural history of angiodysplasia and compare the efficacy of medical therapy, endoscopic electrocoagulation, and surgery, the course of 101 patients evaluated from 1974 through 1983 at the Massachusetts General Hospital was reviewed. " 12/01/1996 - "Electrocoagulation (bicap) of angiodysplasias was performed when accessible and not diffuse (<20). " 06/01/1987 - "While the larger cavernous angiomas necessarily call for surgery, large-bowel angiodysplasia and capillary angiomas, which are disease falling primarily within the internist's sphere of competence, may be treated conservatively, when symptomatic, by endoscopic electrocoagulation, though a surgical approach may be contemplated in that small percentage of cases presenting coagulopathy or frequent, intense haemorrhages with a severe anaemic tendency." 01/01/1987 - "Sixteen patients with gastrointestinal angiodysplasia requiring transfusion were treated with surgical resection, endoscopic electrocautery, or transfusion alone. " 01/01/1985 - "[Colonic angiodysplasia--its treatment by endoscopic electrocoagulation]."
4.	Solid-State Lasers 04/01/1993 - "Nd:YAG laser is a safe and effective treatment for most patients with upper gastrointestinal angiodysplasia." 01/01/1999 - "Moreover, frequency doubled Nd:YAG laser, already used in dermatology for angiodysplasias treatment, could be easily used for resurfacing of periorbital or perioral zones." 12/01/1990 - "Except for cases in which surgical resection is indicated, Nd:YAG laser photocoagulation is the safest, least invasive, and probably most effective means of treating angiodysplasia." 01/01/1993 - "[Treatment with laser Nd YAG of digestive angiodysplasias in dialysed patients with chronic kidney failure]." 01/21/1991 - "Finally, the Nd:YAG laser seems to be able to control bleeding due to gastrointestinal angiodysplasia and to stabilize the course of Rendu-Osler-Weber disease."
5.	Light Coagulation 12/01/1990 - "Except for cases in which surgical resection is indicated, Nd:YAG laser photocoagulation is the safest, least invasive, and probably most effective means of treating angiodysplasia." 04/01/1989 - "Endoscopic electrocoagulation or photocoagulation is now the method of choice for treating colonic angiodysplasia. " 04/01/1991 - "The usual treatment for haemorrhagic angiodysplasia associated with aortic stenosis is the same as for other types of gastrointestinal angiodysplasias: segmental intestinal resection, electrocoagulation and laser photocoagulation. " 07/01/1990 - "This study reports long-term results of treatment of vascular malformations of the gastrointestinal tract by neodymium YAG (Nd-YAG) laser photocoagulation in 60 patients (13 patients with hereditary hemorrhagic telangiectasia and 47 patients with angiodysplasias) and examines prognostic parameters of bleeding recurrence in 47 patients with angiodysplasias. "