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ISCOMs

A formulation for presenting an antigen to induce specific immunologic responses. It consists of an assembly of antigens in multimeric form. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines.
Also Known As:
ISCOM; Immuno-Stimulating Complexes; Complexes, Immuno-Stimulating; Complexes, Immunostimulating; Immuno Stimulating Complexes; Immunostimulating Complexes
Networked: 148 relevant articles (24 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Osterhaus, A D: 5 articles (12/2001 - 08/2000)
2. Jennings, R: 4 articles (02/2003 - 04/2000)
3. Angelos, John A: 3 articles (03/2010 - 12/2004)
4. Hess, John F: 3 articles (03/2010 - 12/2004)
5. Mowat, Allan McI: 3 articles (06/2006 - 05/2002)
6. Garg, Tarun: 2 articles (01/2016 - 01/2014)
7. Rath, Goutam: 2 articles (01/2016 - 01/2014)
8. Lycke, Nils Y: 2 articles (09/2011 - 01/2007)
9. Dauer, Marc: 2 articles (07/2011 - 02/2011)
10. Duewell, Peter: 2 articles (07/2011 - 02/2011)

Related Diseases

1. Infections
2. Human Influenza (Influenza)
3. Virus Diseases (Viral Diseases)
01/01/1995 - "The findings indicate that the ISCOM delivery system can be used for immunisation by the oral route, although in mice, under the conditions used, this strategy compares unfavourably with the intramuscular route in terms of both local and systemic immune responses and protection against homologous challenge virus infection."
01/01/1998 - "In contrast, 2 weeks after infection, virus infected peripheral blood mononuclear cells were only observed in cats vaccinated with FIV-iscoms + vGR657x15-iscoms or CrFK-iscoms and to a lesser extent in cats vaccinated with FIV-iscoms and vGR657x15-iscoms + FIV-Gag-iscoms, but not in cats vaccinated with SIV-iscoms or PBS. "
06/01/1997 - "In aged mice flu-ISCOMs significantly reduced illness and enhanced recovery from viral infection compared with vaccine. "
06/23/2004 - "A large number of experimental ISCOM vaccines have been tested and protection has been induced against a number of pathogens in various species including chronic and persistent infections exemplified by human immune deficiency virus 1 (HIV-1), and 2 (HIV-2) and simian immune deficiency virus (SIV) in primates, and various herpes virus infections in several species. "
10/01/1993 - "Although the overall greatest levels of antibody and protection were elicited in mice following live virus infection, formulation of influenza surface haemagglutinin (HA) and neuraminidase (NA) proteins into ISCOMs elicited high and persistent antibody responses and provided relatively good protection of the upper and lower respiratory tracts of these animals. "
4. Measles
5. Morbillivirus Infections

Related Drugs and Biologics

1. Vaccines
2. ISCOMs
3. Antigens
4. Subunit Vaccines
5. Proteins (Proteins, Gene)
6. Membrane Proteins (Integral Membrane Proteins)
7. Glycoproteins (Glycoprotein)
8. Membrane Glycoproteins (Membrane Glycoprotein)
9. Phosphates (Orthophosphate)
10. Antibodies

Related Therapies and Procedures

1. Mucosal Administration
2. Intramuscular Injections
3. Immunotherapy
4. Drug Therapy (Chemotherapy)
5. Oral Administration