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POEMS Syndrome (Syndrome, POEMS)

A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)
Also Known As:
Syndrome, POEMS; Syndrome, Crow-Fukase; Polyneuropathy Organomegaly; Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome; Crow Fukase Syndrome; Organomegalies, Polyneuropathy; Organomegaly, Polyneuropathy; Polyneuropathy Organomegalies; Syndrome, Takatsuki's; Takatsuki Syndrome; Crow-Fukase Syndrome; Takatsuki's Syndrome
Networked: 761 relevant articles (68 outcomes, 42 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. POEMS Syndrome (Syndrome, POEMS)
2. Plasmacytoma
3. Pulmonary Hypertension
4. Neoplasms (Cancer)
5. Polyneuropathies (Polyneuropathy)

Experts

1. Kuwabara, Satoshi: 36 articles (06/2021 - 08/2002)
2. Li, Jian: 35 articles (11/2021 - 11/2010)
3. Misawa, Sonoko: 31 articles (06/2021 - 01/2007)
4. Dispenzieri, Angela: 27 articles (12/2022 - 04/2003)
5. Zhou, Dao-Bin: 19 articles (11/2021 - 11/2010)
6. Cao, Xin-Xin: 16 articles (11/2021 - 12/2012)
7. Nakaseko, Chiaki: 15 articles (01/2021 - 08/2008)
8. Cai, Hao: 13 articles (11/2021 - 06/2014)
9. Zhang, Wei: 12 articles (08/2018 - 11/2010)
10. Gertz, Morie A: 10 articles (01/2022 - 04/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to POEMS Syndrome:
1. Lenalidomide (CC 5013)FDA Link
2. Dexamethasone (Maxidex)FDA LinkGeneric
3. Thalidomide (Thalomid)FDA Link
4. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
5. Proteins (Proteins, Gene)FDA Link
6. Bortezomib (Velcade)FDA Link
7. Melphalan (Alkeran)FDA LinkGeneric
8. Adrenal Cortex Hormones (Corticosteroids)IBA
9. Biomarkers (Surrogate Marker)IBA
10. SteroidsIBA

Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Stem Cell Transplantation
4. Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
5. Radiotherapy