Intracranial Tuberculoma

A well-circumscribed mass composed of tuberculous granulation tissue that may occur in the cerebral hemispheres, cerebellum, brain stem, or perimeningeal spaces. Multiple lesions are quite common. Management of intracranial manifestations vary with lesion site. Intracranial tuberculomas may be associated with SEIZURES, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. Spinal cord tuberculomas may be associated with localized or radicular pain, weakness, sensory loss, and incontinence. Tuberculomas may arise as OPPORTUNISTIC INFECTIONS, but also occur in immunocompetent individuals.

Also Known As:

Networked: 66 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Meningitis
2.	Glioma (Gliomas)
3.	Tuberculosis (Tuberculoses)
4.	Meningeal Tuberculosis (Tuberculous Meningitis)
5.	Miliary Tuberculosis

Experts

1.	Radhakrishnan, V V: 2 articles (07/2007 - 07/2001)
2.	Suresh, Praveen Karenahalli: 1 article (04/2015)
3.	Madhusudan, Hassan Vijayendra: 1 article (04/2015)
4.	Subramaniam, Venugopal: 1 article (04/2015)
5.	Krishnamoorthy, Naveen: 1 article (04/2015)
6.	Chakrabarti, Subrata: 1 article (12/2014)
7.	Raghavendra, Bs: 1 article (11/2014)
8.	Nethra, Hn: 1 article (11/2014)
9.	Marulasiddappa, Vinay: 1 article (11/2014)
10.	Urtasun, Miguel: 1 article (03/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intracranial Tuberculoma:

1.	Thalidomide (Thalomid)FDA Link 03/01/2013 - "Adjunctive thalidomide may have a role in the management of refractory intracranial tuberculomas, although it should be used conservatively owing to its potential adverse events." 03/01/2013 - "Clinical response to thalidomide in the treatment of intracranial tuberculomas: case report." 10/01/2003 - "The immunomodulatory effects of thalidomide may have a role in the acute and chronic management of TBM complicated by intracranial tuberculomas." 10/01/2003 - "The use of thalidomide in the treatment of intracranial tuberculomas in adults: two case reports." 03/01/2013 - "We describe a patient with multiple intracranial tuberculomas resistant to standard care with antituberculosis drugs and corticosteroids who responded well to thalidomide. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/2013 - "We describe a patient with multiple intracranial tuberculomas resistant to standard care with antituberculosis drugs and corticosteroids who responded well to thalidomide. "
3.	Protons (Proton)IBA 03/01/2007 - "Thirty-three patients with intracranial tuberculomas (histologically confirmed in 22) were evaluated using proton density/T2-weighted, T1-weighted (with and without MT), and echo-planar diffusion-weighted imaging sequences. " 09/01/2002 - "Proton MR spectroscopy and diffusion-weighted MR imaging for the diagnosis of intracranial tuberculomas. " 01/01/1995 - "In vivo proton magnetic resonance spectroscopy (MRS) was performed in ten patients with intracranial tuberculomas with the aim of finding biochemical finger prints which may help in the noninvasive diagnosis of the disease. " 01/01/1995 - "In vivo localized proton magnetic resonance spectroscopy of intracranial tuberculomas." 01/01/1993 - "Intracranial tuberculomas: MRI signal intensity correlation with histopathology and localised proton spectroscopy."
4.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 04/01/2012 - "This preliminary study suggests that in newly diagnosed, untreated intracranial tuberculomas, 11C-methionine, like 18F-FDG, may have limited specificity in distinguishing it from a neoplastic lesion. " 04/01/2012 - "11C-methionine PET/CT followed by 18F-FDG PET/CT study was performed on 12 patients with intracranial tuberculomas. " 04/01/2012 - "The aim of this study was to explore the value of 11C-methionine PET/CT and 18F-FDG in the evaluation of intracranial tuberculomas. " 04/01/2012 - "Metabolic assessment of intracranial tuberculomas using 11C-methionine and 18F-FDG PET/CT."
5.	Isoniazid (Ftivazide)FDA LinkGeneric 10/01/1999 - "Its good penetration into the central nervous system and its distribution into macrophages suggest that this drug may be of interest for the treatment of intracranial tuberculomas, particularly those due to isoniazid-resistant strains." 01/01/2013 - "Isoniazid- and streptomycin-resistant miliary tuberculosis complicated by intracranial tuberculoma in a Japanese infant." 10/01/2011 - "Isoniazid-resistant intracranial tuberculoma treated with a combination of moxifloxacin and first-line anti-tuberculosis medication." 04/01/2001 - "We diagnosed him as intracranial tuberculoma and anti-tuberculous drugs(isoniazid, ethambutol, pyrazinamide) were administered. " 10/01/1997 - "A tentative diagnosis of multiple intracranial tuberculoma was made, and anti-tuberculous drugs (isoniazid 400 mg, ethambutol 750 mg, and pyrazinamide 1.5 g) were administered. "
6.	Streptomycin (Streptomycin Sulfate)FDA Link 05/01/1952 - "[Combined surgical and streptomycin treatment of intracranial tuberculomas]." 02/01/1950 - "The value of streptomycin in the surgical treatment of intracranial tuberculoma." 01/01/2013 - "Isoniazid- and streptomycin-resistant miliary tuberculosis complicated by intracranial tuberculoma in a Japanese infant."
7.	Tuberculin (PPD)IBA 03/01/2008 - "We conclude that a high index of suspicion is essential to make an early diagnosis of intracranial tuberculoma, since often, traditional TB tests like PPD and sputum examinations can be negative." 01/01/1995 - "A 47-year-old German female patient is described with intracranial tuberculoma of the dura mater without history or evidence of tuberculosis and a negative tuberculin reaction. "
8.	SteroidsIBA 11/01/2004 - "Development of intracranial tuberculoma during antituberculous therapy, although rare, dose not represent treatment failure, and continuation of antituberculous drugs, with or without the addition of steroids, will usually resolve the lesions." 01/01/2012 - "A case of a young female systemic lupus erythematosus patient (on prolonged steroids) with intracranial tuberculoma is presented here. "
9.	PyrazinamideFDA LinkGeneric 04/01/2001 - "We diagnosed him as intracranial tuberculoma and anti-tuberculous drugs(isoniazid, ethambutol, pyrazinamide) were administered. " 10/01/1997 - "A tentative diagnosis of multiple intracranial tuberculoma was made, and anti-tuberculous drugs (isoniazid 400 mg, ethambutol 750 mg, and pyrazinamide 1.5 g) were administered. "
10.	Ethambutol (Myambutol)FDA LinkGeneric 04/01/2001 - "We diagnosed him as intracranial tuberculoma and anti-tuberculous drugs(isoniazid, ethambutol, pyrazinamide) were administered. " 10/01/1997 - "A tentative diagnosis of multiple intracranial tuberculoma was made, and anti-tuberculous drugs (isoniazid 400 mg, ethambutol 750 mg, and pyrazinamide 1.5 g) were administered. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/1998 - "The aim of this study was to determine the radiological evolution of intracranial tuberculomas under standard anti-tuberculous drug therapy and to establish guidelines for better management of these patients. " 01/01/2006 - "(1) Paradoxical responses to intracranial tuberculoma/neurotuberculosis can occur at any time even up to 1 year during chemotherapy despite a regular standard antitubercular treatment. " 01/01/2006 - "Ten children with intracranial tuberculomas/neurotuberculosis were retrospectively studied, who were on regular antituberculous chemotherapy. " 07/01/2005 - "Paradoxical enlargement of intracranial tuberculomas or development of new ones during adequate antituberculous chemotherapy is an uncommon event. " 09/01/1997 - "Multiple intracranial tuberculomas with atypical response to tuberculostatic chemotherapy: literature review and a case report."
2.	Craniotomy 04/01/2015 - "This case being one of the rare ones and is also unique wherein the indication for craniotomy being intracranial tuberculoma that is not yet reported in the literature. " 04/01/2015 - "We report the first case of a postcraniotomy STA pseudoaneurysm induced EDH following craniotomy for intracranial tuberculoma. " 05/01/2012 - "Craniotomy is indicated for patients with intracranial hypertension, while more conservative therapy is appropriate for patients who have intracranial tuberculomas without intracranial hypertension."
3.	Catheters 12/01/2012 - "Symptomatic, paradoxical intracranial tuberculomas along non-functional ventricular catheter necessitating its removal."
4.	Highly Active Antiretroviral Therapy (HAART) 04/01/1998 - "Military tuberculosis with paradoxical expansion of intracranial tuberculomas complicating human immunodeficiency virus infection in a patient receiving highly active antiretroviral therapy."
5.	Transplants (Transplant) 01/01/2003 - "A review of the literature reveals that the rare occurrence of intracranial tuberculoma should be considered in an orthotopic liver transplant (OLT) patient with central nervous system pathology." 01/01/2003 - "Intracranial tuberculoma in a liver transplant patient: first reported case and review of the literature."