Hypocapnia

10/01/2002 - "Further physiologic benefits include improved oxygen delivery and neuroprotection, the latter through both avoidance of accidental hypocapnia, which is associated with a poor neurologic outcome, and direct cellular effects. "
11/01/1986 - "The present study was performed first to examine whether a maximal decline in coronary sinus (CS) oxygen content was reached during hypocapnia. "
12/01/2014 - "The brain extracted more oxygen in face of hypocapnia (34% to 53%) or cerebral hypoperfusion (34% to 57%) to compensate for reductions in delivery. "
12/01/2014 - "In a subset of subjects' arterial-to-jugular venous differences were obtained to examine the independent impact of hypocapnia or cerebral hypoperfusion (following INDO) on cerebral oxygen delivery and extraction. "
01/15/2013 - "SNP challenge in these fish, on the contrary, produced a rise in oxygen load together with hypocapnia but without an effect on HCO(3) content, indicating a modulator role of NO in respiratory gas transport during stress response. "

03/15/2011 - "In all cases, increased phrenic burst amplitude was observed following restoration of respiratory neural activity (hypocapnia: 92±22%; isoflurane: 65±22%; HFV: 54±13% baseline), which was significantly greater than time controls receiving the same surgery, but no interruptions in respiratory neural activity (3±5% baseline, p<0.05). "
06/01/1990 - "The study was designed to determine whether isoflurane, when administered during hypocapnia, acted as a cerebral vasodilator to increase either CBF or CBV. "
05/01/2005 - "Hypocapnia restored cerebral autoregulation in normal subjects during isoflurane-induced impairment of autoregulation."
05/01/2005 - "The effect of hypocapnia on the autoregulation of cerebral blood flow during administration of isoflurane."
11/01/1994 - "The results show that during hypocapnia isoflurane causes significant reductions in MAP and CCP whereas ICP and CFV tend to diminish but not significantly. "

11/01/1999 - "In the Normo trial, the inspired CO(2) fraction was 3% to prevent hypocapnia. "
03/01/2011 - "Mean MCA and ACA blood flow velocities at rest, CV40, and CO(2) reactivity during hypocapnia increased significantly after GV20 acupuncture treatment, whereas mean arterial blood pressure and pulse rate at rest did not change significantly. "
03/01/2011 - "The effects of GV20 acupuncture treatment on middle cerebral artery (MCA) and anterior cerebral artery (ACA) blood flow velocities, and CO(2) reactivity during hypocapnia were evaluated in 10 healthy male subjects (mean age 25.6 ± 0.8 years). "
01/01/2010 - "Hypocapnia (2% CO(2)) increased the burst rate in the piriform-amygdala complex but decreased the C(4) inspiratory burst rate. "
01/01/2009 - "Our results suggest that increased cerebral blood flow during stimulation causes CO(2) washout which then results in a post-stimulus hypocapnia induced vasoconstrictive effect."

01/01/1995 - "Severe hypocapnia (< 20 mmHg) may result in cerebral production of lactate; however no studies have shown that a Paco2 in the range of 23-28 mmHg has deleterious effects. "
04/01/2003 - "However, despite continuing hypocapnia there is secondary recovery of CBF over time as a result of increases in lactic acid production. "
11/01/2002 - "In protocol 3, i.v EtOH produced small but significant changes in Scvo, intracranial pressure, and lactate, at normo-, hyper-, and hypocapnia. "
09/01/1994 - "One patient had elevated CSF lactate when she was younger and her HV was more intensive, but now her CSF and blood lactate were normal; her acid-base balance showed mild hypocapnia but was otherwise normal. "
06/01/1988 - "The relationship between striated muscle tissue oxygenation during hyper- and hypocapnia, and lactate levels and venous pO2 (pvO2) was studied in a rabbit model. "

10/01/1989 - "The specificity of this adaptation was supported by showing that Na+-dependent uptake of D-[3H]glucose by BBMV was not significantly different between chronic hypocapnia and control. "
03/01/1989 - "The effect of hypocapnia on regional cerebral glucose utilization (L-CMRg) was studied in 14 Sprague Dawley rats. "
03/01/1989 - "Effect of hypocapnia on local cerebral glucose utilization in rats."
03/01/1989 - "In the hypocapnic group glucose decreased from 71 +/- 3 to 19 +/- 2 mg/100 ml. CBF decreased with hypocapnia to 62 +/- 5% of control in NG but remained at control in HG. This was not accompanied by changes in cerebral oxygen consumption; however, a flat EEG occurred in all HG hypocapnic animals. "
11/01/1982 - "Transfer across the human blood-brain barrier: evidence for capillary recruitment and for a paradox glucose permeability increase in hypocapnia."

01/01/1997 - "The aim of this study was to investigate the modification of the resistive inspiratory properties of the respiratory system associated with hypocapnia in the presence of nicardipine. "
05/01/1990 - "The study of the interaction of nicardipine and hypocapnia on the cerebral arteries show that hypocapnia antagonizes the cerebral vasodilatator properties of nicardipine."
05/01/1990 - "The action of nicardipine in presence of hypocapnia was not yet study in human. "
01/01/1997 - "Combined effects of hypocapnia and nicardipine on airway resistance: a pilot study."
09/01/1991 - "We noninvasively evaluated the effects of nicardipine on cerebral vascular responses to hypocapnia and blood flow velocity in the middle cerebral artery of 10 patients aged 17-60 (mean +/- SD 46.1 +/- 11.8) years. "

01/01/1982 - "Adenosine infusion during hypocapnia was least effective in dilating the coronary vasculature. "
11/01/1987 - "During continuous adenosine infusion (7.5 +/- 0.3 mg/kg/h) which increased MBF 116% during normocapnia, creating hypocapnia caused a 40% decrease in MBF. "
11/01/1987 - "The present study was performed to examine if hypocapnia and hypercapnia might influence the sensitivity to exogenous administration of adenosine. "
12/01/1985 - "Profound hypotension induced with adenosine does not eliminate CO2 reactivity, nor does it lower blood flow to ischemic levels in this model, even in the presence of severe hypocapnia."
12/01/1985 - "Cerebrovascular effects of hypocapnia during adenosine-induced arterial hypotension."

12/01/1990 - "In this model, prior institution of hypocapnia prevented nimodipine-induced global CBF increases."
12/01/1990 - "Hypocapnia decreased local CBF in all structures examined, whereas nimodipine increased local CBF in some, but not all structures. "
12/01/1990 - "Although nimodipine increased global CBF (p <0.05) during normocapnia (89 +/- 8 versus 61 +/- 4 ml/100 g/min), during hypocapnia there was no significant difference between nimodipine and vehicle (45 +/- 3 versus 40 +/- 2 ml/100 g/min). "
12/01/1990 - "Hypocapnia decreased global CBF (p <0.0001) and nimodipine increased CBF (p <0.05). "
12/01/1990 - "Animals were randomized into four experimental groups in a 2 x 2 factorial design, employing Paco2 level and drug group as between-group factors: vehicle plus normocapnia (group 1, n = 6), nimodipine plus normocapnia (group 2, n = 7), vehicle plus hypocapnia (group 3, n = 6), and nimodipine plus hypocapnia (group 4, n = 6). "

04/01/1992 - "CBF was significantly greater during normocapnia compared with hypocapnia at all levels of CPP, except at 35% of control when the values were similar. "
04/01/1992 - "In this study in dogs we investigated cerebral vascular responses to graded decreases of cerebral perfusion pressure (CPP) (100%, 60%, 45%, and 35% of control CPP) during normocapnia (PaCO2 = 37 mm Hg) and hypocapnia (PaCO2 = 21 mm Hg). "
01/01/2012 - "The consequences of moderate hypocapnia (HC) on the autoregulation of cerebral perfusion pressure (CPP) have not been monitored so far.Thirty"
09/16/2008 - "Despite marked changes in CPP, there were no evident change in transfer-function gain, coherence, MAP variability or BRS; however, both MCAv variability and phase in the very-low frequency range was reduced during the most severe level of hyper- and hypocapnia (P < 0.05), and were related to elevations in ventilation (R2 = 0.42-0.52, respectively; P < 0.001). "
11/01/2002 - "With EtOH, CPP was maintained and cerebral blood flow appeared to be adequate, if not excessive, with respect to cerebral metabolic demand, as judged by changes in Scvo at normo-, hyper-, and hypocapnia. "

05/01/1996 - "Determination of whether variation in sensitivity to hypocapnia may be helpful in determining response to antiepileptic drugs (AEDs) or remission of seizures will require further study."

12/01/2001 - "In the present study we investigated the effect of hypocapnia during anesthesia on neuronal damage using a rat model of chronic cerebral hypoperfusion. "
01/15/2012 - "These results provide the first clear evidence that laboratory anesthesia can profoundly alter the regulation of ABs including the hypocapnia-dependent component of their facilitation."
07/01/2006 - "In conclusion, cerebrovascular response to hypocapnia is similar between the normal and the abnormal cerebral hemispheres both under intravenous and inhalational anesthesia."
10/01/2003 - "Hypocapnia is commonly used in anesthesia practice for different indications. "
06/01/1987 - "With maintained pre-anesthetic hypocapnia no further disturbance in acid-base balance occurred during anesthesia. "

01/15/2010 - "Hypocapnia was induced via nasal mechanical ventilation for 3 minutes. "
01/01/2006 - "Hypocapnia was induced via nasal mechanical ventilation for 3 minutes during stable non-rapid eye movement sleep. "
12/01/2004 - "During NREM sleep, hypocapnia was induced via nasal mechanical ventilation. "
01/01/2003 - "Hypocapnia was induced via nasal mechanical ventilation (MV) for 3 min with tidal volumes ranging from 175 to 215% above eupneic tidal volume and respiratory frequency matched to eupneic frequency. "
01/01/2003 - "We determined the effects on breathing of transient ventilatory overshoots and concomitant hypocapnia, as produced by pressure support mechanical ventilation (PSV), in intact and carotid body chemoreceptor denervated (CBX) sleeping dogs. "

03/01/2008 - "The patients operated on by open cholecystectomy had statistically significantly more pronounced disturbances including hypoxia, hypocapnia and hyperventilation when compared to the group submitted to laparoscopic cholecystectomy. "
02/01/2012 - "Does hypocapnia before and during carbon dioxide insufflation attenuate the hemodynamic changes during laparoscopic cholecystectomy?"
02/01/2012 - "The authors conclude that the use of hypocapnia before and during CO(2) insufflation is effective in attenuating increases in blood pressure after CO(2) pneumoperitoneum during anesthesia for laparoscopic cholecystectomy."
02/01/2012 - "Hypocapnia before and during carbon dioxide (CO(2)) insufflation for laparoscopic cholecystectomy may reduce the adverse hemodynamic responses. "

10/01/2012 - "There is a broad consensus that adequate airway management, prevention of hypoxia, hypocapnia or hypercapnia, prevention of hypotension and control of hemorrhage represent preclinical therapeutic modalities that may contribute to improved survival in severe TBI. "

05/01/1986 - "The sustained arteriolar dilation and reduced responsiveness to the vasoconstrictor effects of arterial hypocapnia observed 30 minutes after brain injury were eliminated by after-treatment with topical SOD (60 U/ml) and catalase (40 U/ml). "