CD8 Antigens

Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.

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Networked: 88 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hawinkels, Lukas J A C: 1 article (06/2015)
2.	Jonkers, Jos: 1 article (06/2015)
3.	Weiden, Jorieke: 1 article (06/2015)
4.	Hau, Cheei-Sing: 1 article (06/2015)
5.	Verstegen, Niels J M: 1 article (06/2015)
6.	Kersten, Kelly: 1 article (06/2015)
7.	Ciampricotti, Metamia: 1 article (06/2015)
8.	Coffelt, Seth B: 1 article (06/2015)
9.	Vrijland, Kim: 1 article (06/2015)
10.	de Visser, Karin E: 1 article (06/2015)

Related Diseases

1.	Infection 02/01/2011 - "Until 11 days after infection, the occurrence as well as transcription of the CD8 antigen and immunologically relevant protein genes of CD8α(-) and CD8α(+high) (CD8αα(+) CD8αβ(+)) γδ cells were analyzed using flow cytometry and quantitative real-time reverse transcription-PCR (RT-PCR) with blood, spleen, thymus, and cecum samples. " 06/01/2007 - "Tetramer staining of cord blood after CMV infection has demonstrated that effective CD8(+) antigen-specific immune responses can follow intrauterine viral infections. " 03/01/2004 - "Upon systemic activation by antigens, CD8(+), but not CD4(+), T cells selectively accumulate and undergo apoptosis in the liver, a mechanism associated with the induction of hepatic tolerance and chronic infection. " 12/01/2003 - "Adoptive transfer of IBV-infection-induced alphabeta T cells bearing CD8 antigen protected chicks from challenge infection. " 12/13/2002 - "In order to induce effective CTL responses against most infections and tumours, DCs must prime both CD4(+) and CD8(+) antigen-specific T cells. "
2.	Neoplasms (Cancer) 09/01/2005 - "Spontaneous apoptosis of circulating CD8(+) antigen-responding effector T-cells contributes to rapid lymphocyte turnover and depressed absolute numbers of T-cell subsets observed in patients with cancer. " 07/01/2003 - "CD2, CD3, CD4, and CD8 antigens were detected in none of 447 cases of nonhematopoietic tumors. " 07/01/1999 - "We studied the reactivity of an antibody to the CD8 antigen (C8/144B), recognizing K15, on 66 cutaneous tumors with known or alleged pilar differentiation, in order to assess its usefulness in the diagnosis of this group of tumors. " 09/01/1988 - "Measurement of serum levels of CD8 antigen not only has important prognostic value in childhood lymphoid malignancies but also could be useful in assessing the immunoregulatory role of T cells in patients with cancer." 07/01/1998 - "To explain the significance of these soluble molecules in solid tumors, we a) determinated sIL-2R and sCD8 in 84 patients; b) correlated the expression of p55 chain of IL-2R and CD8 antigen on the cell-surface of peripheral lymphocytes to sIL-2R and sCD8 levels; c) analyzed endogenous IL-2R levels in patients with lung cancer. "
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/01/1997 - "The immature cells of T-cell acute lymphocytic leukemia and lymphoblastic lymphoma represented a dominant uniform population of cells demonstrating strong staining with both the CD4 and CD8 antigens. " 08/01/1990 - "In the present study, we examined a lymphoma derived from a child lymphoblastic lymphoma bearing CD1, CD4, and CD8 antigens and established in nude mice. " 06/01/1992 - "Twenty-four patients expressed CD4 and/or CD8 antigens on their blast cells, designated T acute lymphoblastic leukemia (T-ALL). " 09/01/1988 - "Serum concentrations of CD8 antigen were measured at diagnosis with an enzyme-linked immunoassay in children with acute lymphoblastic leukemia (n = 344) or non-Hodgkin's lymphoma (n = 65). "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 03/01/2007 - "The results of our immunohistological studies indicate that immunostaining with p53, Bcl-2, and CD8 antigens could be useful in differentiating APF from closely related inflammatory conditions such as psoriasis and cutaneous LE. " 01/01/1990 - "Elevated levels of soluble CD8 antigen in sera of patients with psoriasis--a possible sign of suppressor/cytotoxic T-cell activation." 06/01/1991 - "Determination of released CD4 and CD8 antigens in the suction-blister fluid and horny-tissue extract in patients with psoriasis." 06/01/1991 - "The amounts of soluble CD4 and CD8 antigens were measured in suction-blister fluid and extracts of horny tissue in patients with psoriasis. "
5.	Inflammation 08/17/2000 - "Here we show that progression of pancreatic islet inflammation to overt diabetes in nonobese diabetic (NOD) mice is driven by the 'avidity maturation' of a prevailing, pancreatic beta-cell-specific T-lymphocyte population carrying the CD8 antigen. " 10/01/2003 - "In our present study we analyzed the spatiotemporal expression pattern of the CD8 antigen in various rat EAE models characterized by a different extent of inflammation, demyelination, and axonal injury. " 10/01/2001 - "Increased numbers of beta2-MG, HLA-DR, CD3, CD4 and CD8 antigen positive cells are presented in the monkey livers after adenovirus-mediated gene therapy and induce mild to moderate transient hepatic inflammation. "

Related Drugs and Biologics

1.	Antigens
2.	Interleukin-2 Receptors (IL 2 Receptor)
3.	Interleukin-2 (IL2)
4.	T-Cell Antigen Receptors (T-Cell Receptor)
5.	Interferon-gamma (Interferon, gamma)
6.	Antibodies
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Interleukin-2 Receptor beta Subunit
9.	Neopterin
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Splenectomy
2.	Ligation
3.	Immunotherapy