Vivax Malaria

Malaria caused by PLASMODIUM VIVAX. This form of malaria is less severe than MALARIA, FALCIPARUM, but there is a higher probability for relapses to occur. Febrile paroxysms often occur every other day.

Also Known As:

Networked: 690 relevant articles (83 outcomes, 108 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Falciparum Malaria (Plasmodium falciparum Malaria)
2.	Malaria
3.	Infection
4.	Body Weight (Weight, Body)
5.	Fever (Fevers)

Experts

1.	White, Nicholas J: 24 articles (12/2014 - 05/2003)
2.	Baird, J Kevin: 19 articles (06/2015 - 10/2002)
3.	Lacerda, Marcus V G: 14 articles (01/2015 - 09/2008)
4.	Price, Ric N: 14 articles (01/2015 - 02/2007)
5.	Anstey, Nicholas M: 12 articles (01/2015 - 12/2002)
6.	Sattabongkot, Jetsumon: 11 articles (08/2015 - 04/2006)
7.	Davis, Timothy M E: 11 articles (08/2015 - 04/2002)
8.	Singhasivanon, Pratap: 11 articles (11/2012 - 09/2008)
9.	Han, Eun-Taek: 10 articles (08/2015 - 03/2010)
10.	Nosten, François: 10 articles (01/2015 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vivax Malaria:

1.	Chloroquine (Aralen)FDA LinkGeneric 10/01/2014 - "Chloroquine is the first-line treatment for Plasmodium vivax malaria in most endemic countries, but resistance is increasing. " 12/01/2010 - "Chloroquine is the first-line treatment for Plasmodium vivax malaria in most parts of the world. " 03/01/1992 - "More ominously, a resident of the Highlands region of Papua New Guinea contracted vivax malaria which failed to be cleared by 2400 mg chloroquine base administered over 4 d. " 01/01/2015 - "Therapeutic efficacy of chloroquine for the treatment of Plasmodium vivax malaria among outpatients at Hossana Health Care Centre, southern Ethiopia." 10/01/2014 - "Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat province, Western Cambodia."
2.	PrimaquineFDA Link 10/01/2002 - "Radical curative efficacy of five-day regimen of primaquine for treatment of Plasmodium vivax malaria in India." 04/01/2010 - "A 1 week course of primaquine 60 mg daily is an effective treatment of vivax malaria in this region." 07/01/2013 - "This study was designed to assess the efficacy of 8 weeks of primaquine treatment in prevention of relapse in patients with vivax malaria in south and south-east Iran by SSCP-PCR and sequencing. " 07/01/2014 - "Efficacy of three different regimens of primaquine for the prevention of relapses of Plasmodium vivax malaria in the Amazon Basin of Peru." 07/01/2013 - "Assessment of the efficacy of 8 weeks of primaquine for the prevention of relapse in vivax malaria patients using SSCP-PCR and sequencing in South and South-East Iran, 2008-2011."
3.	artesunateIBA 09/01/2004 - "Therapeutic efficacy of artesunate in Plasmodium vivax malaria in Thailand." 11/01/1998 - "A pharmacokinetic and pharmacodynamic study of artesunate for vivax malaria." 02/01/2013 - "A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy." 09/01/2012 - "Intravenous artesunate for transfusion-transmitted plasmodium vivax malaria in a preterm neonate." 09/01/2004 - "In conclusion, artesunate might be useful in treatment of vivax malaria, causing a good blood schizontocidal effect. "
4.	Pyrimethamine (Daraprim)FDA Link 12/01/1965 - "The effect of biweekly administration of 50 mg pyrimethamine in prevention of falciparum and vivax malaria." 01/01/1959 - "Pyrimethamine resistance in Plasmodium vivax malaria." 09/01/1953 - "XXXII. The protective and therapeutic effects of pyrimethamine (daraprim) against Chesson strain vivax malaria." 08/01/1953 - "Pyrimethamine daraprim the treatment of vivax malaria." 06/06/1953 - "Pyrimethamine in treatment of vivax malaria; preliminary report."
5.	artemisinine (artemisinin)IBA 02/22/2014 - "This ambitious but laudable goal faces many challenges, including the worldwide economic downturn, difficulties in elimination of vivax malaria, development of pyrethroid resistance in some anopheline mosquitoes, and the emergence of artemisinin resistance in Plasmodium falciparum in southeast Asia. " 12/01/2013 - "Some of these are to control the spread of resistance in Plasmodium falciparum to artemisinin, control of outdoor transmission, control of vivax malaria and ensuring universal coverage of key interventions. " 01/01/2013 - "Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria." 01/01/2011 - "To compare Artemisinin-based combination therapies (ACTs) with alternative antimalarial regimens for treating acute uncomplicated P.vivax malaria. " 01/01/2011 - "Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria."
6.	pentaquineIBA 05/01/1948 - "Pentaquine (SN-13,276) a therapeutic agent effective in reducing the relapse rate in vivax malaria." 11/01/1946 - "Pentaquine (SN-13,276) a new antimalarial effective in reducing the relapse rate of vivax malaria." 06/01/1948 - "Evaluation of pentaquine as a cure of relapsing vivax malaria; a controlled study of 95 cases." 09/01/1950 - "XXVII. Observations on the use of pentaquine in the prevention and treatment of Chesson strain vivax malaria." 06/15/1949 - "Cure of chronic vivax malaria with pentaquine and status of immunity thereafter."
7.	dihydroquinghaosu (dihydroartemisinin)IBA 09/01/2007 - "Dihydroartemisinin-piperaquine, a fixed-dose combination antimalarial, is an inexpensive, safe and highly effective treatment for uncomplicated falciparum or vivax malaria. " 01/01/2013 - "This study aimed to synthesize available evidence on the efficacy of dihydroartemisinin-piperaquine (DHP) in treating uncomplicated Plasmodium vivax malaria in people living in endemic countries. " 01/01/2013 - "Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium vivax malaria in endemic countries: meta-analysis of randomized controlled studies." 11/01/2011 - "We conducted a randomized controlled study to compare the efficacy and the tolerability of CQ and dihydroartemisinin-piperaquine (DP) in 500 adults and children with acute vivax malaria on the Northwestern border of Thailand. " 01/01/2014 - "The first 80 volunteers with slide-confirmed Plasmodium falciparum or vivax malaria were randomized 1:1 to receive either regimen (total dose 360 mg dihydroartemisinin and 2880 mg piperaquine) and followed weekly for up to 6 months. "
8.	piperaquineIBA 01/01/2014 - "vivax malaria was accommodated by a constant baseline hazard (8.94 relapses/year) with the addition of a surge function in a fixed 3-week interval and a protective piperaquine effect. " 01/01/2014 - "Population Pharmacokinetics and Antimalarial Pharmacodynamics of Piperaquine in Patients With Plasmodium vivax Malaria in Thailand." 03/01/2004 - "Population pharmacokinetics of piperaquine in adults and children with uncomplicated falciparum or vivax malaria." 09/01/2007 - "Dihydroartemisinin-piperaquine, a fixed-dose combination antimalarial, is an inexpensive, safe and highly effective treatment for uncomplicated falciparum or vivax malaria. " 01/01/2013 - "This study aimed to synthesize available evidence on the efficacy of dihydroartemisinin-piperaquine (DHP) in treating uncomplicated Plasmodium vivax malaria in people living in endemic countries. "
9.	Mefloquine (Lariam)FDA LinkGeneric 05/01/1985 - "A clinical trial of mefloquine in the treatment of Plasmodium vivax malaria." 04/05/1993 - "Group 1: 40 men receiving mefloquine were all protected against falciparum malaria but four (10%) developed vivax malaria. " 12/01/1985 - "A comparative clinical study of mefloquine and chloroquine in the treatment of vivax malaria." 03/01/2005 - "Despite regular weekly mefloquine prophylaxis (250 mg/d), the patient presented with a first episode of vivax malaria, which was treated by chloroquine alone, then experienced a second crisis in France. " 12/01/1985 - "Forty-six patients with Plasmodium vivax malaria were evaluated for their clinical and parasitological response to the two single doses of mefloquine in comparison with the standard 3-day treatment with chloroquine. "
10.	atovaquone-proguanilIBA 09/01/2012 - "A cluster of Plasmodium vivax malaria in an expedition group to Ethiopia: prophylactic efficacy of atovaquone/proguanil on liver stages of P. " 10/01/2002 - "Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia." 11/01/2006 - "Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis." 11/01/2002 - "Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity." 11/01/1999 - "Results of this trial indicate that atovaquone-proguanil followed by primaquine is safe and effective for treatment of vivax malaria."

Therapies and Procedures

1.	Chemoprevention 09/07/2015 - "Transmission dynamics of vivax malaria in the republic of Korea: Effectiveness of anti-malarial mass chemoprophylaxis." 05/01/2014 - "Sensitivity of parasitological tests in imported Plasmodium vivax malaria in adults and impact of chemoprophylaxis and attack type." 01/01/2013 - "Suppressive chemoprophylaxis invites avoidable risk of serious illness caused by Plasmodium vivax malaria." 10/01/2011 - "vivax malaria and/or chemoprophylaxis." 01/01/2011 - "Unexpectedly long incubation period of Plasmodium vivax malaria, in the absence of chemoprophylaxis, in patients diagnosed outside the transmission area in Brazil."
2.	Aftercare (After-Treatment) 02/15/2007 - "Progressive alveolar-capillary dysfunction after treatment of vivax malaria is consistent with a greater inflammatory response to a given parasite burden in P. " 03/01/1981 - "vivax malaria before and after treatment. " 06/01/2012 - "Acute disseminated encephalomyelitis after treatment of Plasmodium vivax malaria." 09/01/2008 - "Gametocytemia in vivax malaria was more common in patients with admission parasitemia > 10,000/microL and after treatment with drugs which have weak antimalarial activity, and was also associated with an increased rate of vivax reappearance (29.4% versus 14.1%, P = 0.002). " 02/15/2007 - "The progressive deterioration in D(M) function after treatment was statistically significant in vivax malaria but not in uncomplicated falciparum malaria. "
3.	Drug Therapy (Chemotherapy) 01/01/2012 - "Development of safe and effective chemotherapies for vivax malaria for the coming decades requires overcoming these challenges." 05/01/1948 - "Studies on the chemotherapy of the human malarias; method for the quantitative assay of suppressive antimalarial action in vivax malaria." 06/30/2010 - "Blood samples were collected from vivax malaria patients without antimalarial drug therapy. " 07/01/2009 - "Fielding new drug therapies against real-world vivax malaria may require a reworking of the strategic framework of drug development, namely, the conception, testing, and evaluation of sets of drugs designed for the cure of both blood and liver asexual stages as well as the sexual blood stages within a single therapeutic regimen." 02/01/2009 - "Adherence to antimalarial drug therapy among vivax malaria patients in northern Thailand."
4.	Platelet Transfusion (Blood Platelet Transfusions) 03/01/2014 - "In this study out of 39 children of confirmed vivax malaria 22 had thrombocytopenia, having mean platelet count 48 × 10(9)/L on admission which showed a very quick recovery on treatment and by day 3 of treatment it rose to 126.5 × 10(9)/L without platelet transfusion. "
5.	Splenectomy 01/01/2012 - "We report for the first time in Iran a fatal case of Plasmodium vivax malaria, confirmed by microscopic and molecular (Semi-nested multiplex PCR) tests in a patient who had undergone splenectomy due to hemolytic anemia." 01/01/1974 - "Splenectomy in hereditary spherocytosis: effect on course of relapsing vivax malaria." 02/01/1983 - "[Splenectomy made possible by administration of a massive dosage of IgG in refractory ITP associated with Plasmodium vivax malaria]."