Cerebral Malaria

A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)
Also Known As:
Malaria, Cerebral; Meningitis, Malaria; Malaria Meningitis
Networked: 984 relevant articles (66 outcomes, 130 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Malaria
2. Parasitemia
3. Infection
4. Coma (Comas)
5. Shock


1. Hunt, Nicholas H: 18 articles (02/2016 - 09/2003)
2. Taylor, Terrie E: 17 articles (01/2015 - 04/2003)
3. Grau, Georges E: 17 articles (01/2014 - 10/2002)
4. Molyneux, Malcolm E: 15 articles (01/2015 - 04/2003)
5. Kain, Kevin C: 15 articles (01/2014 - 01/2006)
6. Ball, Helen J: 13 articles (02/2016 - 02/2004)
7. Looareesuwan, Sornchai: 13 articles (09/2010 - 01/2002)
8. John, Chandy C: 12 articles (07/2015 - 09/2006)
9. Carvalho, Leonardo J M: 11 articles (10/2015 - 01/2006)
10. Anstey, Nicholas M: 11 articles (03/2015 - 02/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cerebral Malaria:
1. artemetherFDA Link
2. Quinine (Quinson)FDA Link
3. artemisinine (artemisinin)IBA
4. artesunateIBA
5. AntibodiesIBA
6. Chloroquine (Aralen)FDA LinkGeneric
7. arteether (artemotil)IBA
8. Mefloquine (Lariam)FDA LinkGeneric
9. atorvastatin (Lipitor)FDA Link
10. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA

Therapies and Procedures

1. Enteral Nutrition (Feeding, Tube)
2. Intranasal Administration
3. Drug Therapy (Chemotherapy)
4. Chelation Therapy (Therapy, Chelation)
5. Renal Dialysis (Hemodialysis)
02/01/1999 - "Eleven of the patients who died were jaundiced and eight of them had cerebral malaria with a Glasgow Coma Score < or = 8. We conclude that hemodialysis is a useful treatment for oliguric and nonoliguric ARF from severe malaria, particularly when initiated early in the course of the illness."
03/01/1998 - "In addition, a number of subsidiary outcome variables were examined in specific subgroups, including the recovery time from coma for patients with cerebral malaria, the duration of intubation in patients with respiratory distress, the number of hemodialysis treatments needed for patients with acute renal failure, and the number of units of blood administered to patients requiring transfusion. "
02/01/1994 - "All of them had evidence of intrahepatic cholestasis and needed hemodialysis for several weeks; 7 survived and 2 died, one due to cerebral malaria, the other multiple organ failure. "
10/02/2000 - "These longitudinal data suggest that: (i) severe falciparum malaria is associated with skeletal muscle damage that increases during initial therapy especially in patients with coma; (ii) the effect of other major treatment or infection-specific factors that are associated with muscle damage does not diminish this relationship; and (iii) cerebral malaria in combination with a high baseline and rising serum CK should pre-empt monitoring and management strategies aimed at preserving renal function including renal dialysis."
03/01/1998 - " There were no significant differences between groups in terms of parasite and fever clearance time, recovery time from coma in patients with cerebral malaria, duration of intubation in patients with respiratory distress, number of hemodialysis treatments required for patients with acute renal failure, or number of units of blood administered to patients in need of transfusion. "