Feline Infectious Peritonitis

Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.

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Networked: 86 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Neoplasms (Cancer)
3.	Inflammation
4.	Ascites
5.	Vasculitis (Vasculitides)

Experts

1.	Paltrinieri, Saverio: 9 articles (06/2015 - 06/2004)
2.	Giordano, Alessia: 6 articles (06/2015 - 06/2004)
3.	Hohdatsu, Tsutomu: 4 articles (12/2013 - 12/2003)
4.	Takano, Tomomi: 3 articles (12/2013 - 01/2007)
5.	Rottier, Peter J M: 3 articles (07/2012 - 04/2004)
6.	Paltrinieri, S: 3 articles (06/2011 - 01/2004)
7.	Hartmann, Katrin: 3 articles (06/2008 - 01/2007)
8.	Rossi, Gabriele: 2 articles (06/2015 - 04/2009)
9.	Farsang, Attila: 2 articles (01/2014 - 05/2012)
10.	Siddell, Stuart G: 2 articles (01/2014 - 06/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Feline Infectious Peritonitis:

1.	AntigensIBA 01/01/1992 - "In a study to determine the efficacy of an anti-idiotypic vaccine against feline infectious peritonitis (FIP), cats that were immunized with a pool of monoclonal Ab2s developed Ab3s that recognized the variable regions of the Ab2s as well as the natural antigen. " 11/01/2013 - "Diagnostic utility of a direct immunofluorescence test to detect feline coronavirus antigen in macrophages in effusive feline infectious peritonitis." 11/01/2007 - "Feline infectious peritonitis was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. " 12/01/2005 - "The detection of typical lesions and feline coronavirus (FCoV) antigen in tissues is the only conclusive method for making a diagnosis of feline infectious peritonitis (FIP). " 10/23/1998 - "Twenty-three cats with spontaneous feline infectious peritonitis (FIP) were examined by light microscopy including immunohistology and histochemistry in order to determine the cellular composition and the expression of viral antigen in lesions in FIP. "
2.	Nucleocapsid ProteinsIBA 12/02/2003 - "Vaccine efficacy of a cell lysate with recombinant baculovirus-expressed feline infectious peritonitis (FIP) virus nucleocapsid protein against progression of FIP."
3.	VaccinesIBA 04/01/2004 - "Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis."
4.	AntibodiesIBA 01/01/1989 - "On the basis of ELISA antibody titers obtained in sera from the cats experimentally infected with CCV and from the spontaneous feline infectious peritonitis (FIP) cases, the ELISA described in the present study was found to be applicable as a simple and easy serologic test which was able to detect anti-coronavirus antibodies as efficiently as the indirect immunofluorescence assay with homologous FIP virus." 09/01/2008 - "To determine whether expression of feline coronavirus (FCoV) 7b protein, as indicated by the presence of specific serum antibodies, consistently correlated with occurrence of feline infectious peritonitis (FIP) in cats. " 09/01/2008 - "Evaluation of antibodies against feline coronavirus 7b protein for diagnosis of feline infectious peritonitis in cats." 09/01/1987 - "[Comparative studies of the demonstration of antibodies to feline infectious peritonitis (FIP) by immunofluorescence and enzyme immunoassay (ELISA)]." 01/01/1987 - "[The detection of antibodies against the feline infectious peritonitis (FIP) virus using the indirect immunofluorescence test]."
5.	Interferon-gamma (Interferon, gamma)IBA 06/02/2011 - "Interferon gamma (IFN-γ) plays an important role in cell mediated responses against mutated feline coronavirus strains (FCoV) involved in the pathogenesis of feline infectious peritonitis (FIP). " 11/30/2005 - "Cellular composition and interferon-gamma expression of the local inflammatory response in feline infectious peritonitis (FIP)." 06/01/2009 - "The aim of this study was to quantify and compare interferon-gamma (IFN-gamma) concentrations in the serum of clinically normal cats infected with feline coronavirus (FCoV) with its concentration in the sera and effusions of cats with feline infectious peritonitis (FIP), a disease associated with infection with a mutated form of FCoV. " 02/26/2002 - "We previously showed that an intraperitoneal infection with mouse hepatitis virus (MHV) persists in interferon-gamma (IFN-gamma)-deficient C57BL/6 (B6-GKO) mice and results in subacute fatal peritonitis, which bears a resemblance to feline infectious peritonitis. "
6.	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 12/01/2006 - "In this study, the cytokine profiles of clinically healthy cats naturally infected with feline coronavirus (FCoV), of cats with feline infectious peritonitis (FIP) and of specific pathogen-free (SPF) cats were investigated in whole blood using a traditional reverse-transcriptase polymerase chain reaction (RT-PCR) assay and a semi-quantitative method of analysis based on computerised quantification of positive bands. " 07/01/1998 - "Detection of feline coronaviruses by culture and reverse transcriptase-polymerase chain reaction of blood samples from healthy cats and cats with clinical feline infectious peritonitis." 10/01/2007 - "Blood samples were tested for feline coronavirus (FCoV) messenger RNA (mRNA) by an reverse transcriptase-polymerase chain reaction (RT-PCR) assay which has previously been described to have a high specificity in the diagnosis of clinical FIP [Simons AF, Vennema H, Rofina JE, Pol JM, Horzinek MC, Rottier PJM, Egberink HF (2005) A mRNA PCR for the diagnosis of feline infectious peritonitis. "
7.	InterferonsIBA 05/01/1990 - "Seventy-four cats (52 treated and 22 untreated) were evaluated in efficacy studies of interferon (IFN), Propionibacterium acnes, or a combination of these drugs against experimentally induced feline infectious peritonitis (FIP). " 01/01/2014 - "Identification and genotyping of feline infectious peritonitis-associated single nucleotide polymorphisms in the feline interferon-γ gene." 04/01/2004 - "A total of 12 clinically ill cats previously diagnosed as feline infectious peritonitis (FIP) were treated with a combination of recombinant feline interferon and glucocorticoid. " 04/01/2004 - "Use of recombinant feline interferon and glucocorticoid in the treatment of feline infectious peritonitis." 05/01/1990 - "Effect of interferon or Propionibacterium acnes on the course of experimentally induced feline infectious peritonitis in specific-pathogen-free and random-source cats."
8.	Immunoglobulin G (IgG)IBA 01/15/2007 - "To assess the use of measuring anti-coronavirus IgG in CSF for the diagnosis of feline infectious peritonitis (FIP) involving the CNS in cats. " 06/01/2008 - "The purpose of this study was to validate nephelometric methods for CSF protein analysis, and to use the Q(alb) and IgG index to discriminate blood- and brain-derived immunoglobulin fractions in cats with feline infectious peritonitis (FIP). " 06/01/2008 - "Use of albumin quotient and IgG index to differentiate blood- vs brain-derived proteins in the cerebrospinal fluid of cats with feline infectious peritonitis." 01/01/1987 - "Peritoneal exudate of a cat affected with feline infectious peritonitis (FIP) was used to isolate an IgG-globulin, employing affinity chromatography, and conjugate it with fluorescein isothiocyanate. "
9.	N-Acetylneuraminic Acid (Sialic Acid)IBA 10/01/2008 - "Variations of AGP sialylation were recorded only in cats from group C, on which viral shedding peaked before the occurrence of feline infectious peritonitis (FIP) in the cattery, and decreased 1 month later, when serum AGP had an increase of alpha(2,3)-linked sialic acid. " 04/01/2009 - "The aims of this study were to validate a colorimetric method to measure total sialic acid (TSA) in feline serum and to investigate the serum concentration of TSA in clinically healthy cats seronegative (n = 9) and seropositive (n = 48) for feline coronavirus (FCoV), and in cats affected by feline infectious peritonitis (FIP, n = 28), tumors (n = 20), or inflammation (n = 16). "
10.	Immunoglobulins (Immunoglobulin)IBA 06/01/2008 - "The purpose of this study was to validate nephelometric methods for CSF protein analysis, and to use the Q(alb) and IgG index to discriminate blood- and brain-derived immunoglobulin fractions in cats with feline infectious peritonitis (FIP). " 01/01/2004 - "The possible role of some acute phase proteins (APPs) and immunoglobulins in both the pathogenesis and diagnosis of feline infectious peritonitis (FIP) has been investigated. " 01/01/2004 - "Changes in some acute phase protein and immunoglobulin concentrations in cats affected by feline infectious peritonitis or exposed to feline coronavirus infection."

Therapies and Procedures

1.	Therapeutics 08/01/2014 - "This review is concerned with what has been learned about feline infectious peritonitis (FIP) diagnostics and therapeutics since the publication of an extensive overview of literature covering the period 1963-2009. " 08/01/2014 - "An update on feline infectious peritonitis: diagnostics and therapeutics."