Erythema Infectiosum

Contagious infection with human B19 Parvovirus most commonly seen in school age children and characterized by fever, headache, and rashes of the face, trunk, and extremities. It is often confused with rubella.

Also Known As:

Networked: 49 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Edema
3.	Erythema Infectiosum
4.	Hydrops Fetalis (Fetal Edema)
5.	Arthralgia (Joint Pain)

Experts

1.	Tsutsumi, Hiroyuki: 1 article (12/2014)
2.	Ishikawa, Aki: 1 article (12/2014)
3.	Yoto, Yuko: 1 article (12/2014)
4.	Tsugawa, Takeshi: 1 article (12/2014)
5.	Shiozawa, Ryosuke: 1 article (01/2013)
6.	Kitanaka, Sachiko: 1 article (01/2013)
7.	Hangai, Mayumi: 1 article (01/2013)
8.	Takeuchi, Masato: 1 article (01/2013)
9.	Takita, Junko: 1 article (01/2013)
10.	Ozdemir, Mehmet: 1 article (07/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Erythema Infectiosum:

1.	Neutralizing AntibodiesIBA 01/01/2007 - "To check the clearance of parvovirus B19 in the course of the development of neutralizing antibodies after Erythema infectiosum in pregnancy. " 01/01/2007 - "Prolonged parvovirus b19 viremia in spite of neutralizing antibodies after erythema infectiosum in pregnancy."
2.	DNA (Deoxyribonucleic Acid)IBA 12/01/2014 - "However, no large-scale study quantitating levels of B19V DNA in common or representative B19V manifestations such as erythema infectiosum and aplastic crisis has been performed. " 12/01/2014 - "Although all subjects followed an almost uniform and typical clinical course of erythema infectiosum, there was a large individual variation of B19V DNA loads, that is differences of over 1,000 times. " 12/01/2014 - "In the acute phase of erythema infectiosum the median B19V DNA load in the serum samples from the acute phase of erythema infectiosum was 7.63 × 10(5)  genomes/ml, (range from 4.48 × 10(3) to 8.31 × 10(6)  genomes/ml). " 12/01/2014 - "Quantitation of human parvovirus B19 DNA in erythema infectiosum and aplastic crisis." 01/01/1993 - "The years when B19 DNA was detected from the 9 patients corresponded to the prevalence of erythema infectiosum in Japan."
3.	Immunoglobulin M (IgM)IBA 01/01/2013 - "Anti-parvovirus IgM titer was elevated during hospitalization and typical erythema infectiosum was seen approximately 1 week after discharge. " 05/01/1997 - "Records of IgM-positive residents contained no evidence of erythema infectiosum or polyarthropathy." 10/01/1995 - "Thirty-six (97%) of the 37 patients with erythema infectiosum and all (100%) of the 4 patients with aplastic crisis were positive for B19 IgM. " 08/01/1990 - "At onset of erythema infectiosum anti-B19 IgM was detected in titers of 10(-4) and was positive up to 19 weeks. " 04/01/1988 - "In a second case-control study of women who had stillbirths after outbreaks of erythema infectiosum in area schools, none of the 20 patients or 26 controls were IgM positive at the time of delivery. "
4.	Immunoglobulin G (IgG)IBA 12/01/1996 - "Erythema infectiosum is a childhood disease (96% of the cases are children under 14 years of age), but seroprevalence of parvovirus IgG in these age groups is only 11%. " 06/01/1993 - "1) After the period of prevalence of erythema infectiosum(EI) between 1986 and 1987, the positive rate of anti B19 IgG antibody by sandwich ELISA in the sera from subjects aged 15-34 years old was 17-26%. " 08/01/1990 - "Anti-B19 IgG could be detected in clinical specimens one week after onset of erythema infectiosum and persisted in titers up to 10(-6) throughout the convalescent period. " 11/01/1984 - "Seven of the controls were also anti human parvovirus IgG negative, and the 10 who were seropositive had lower concentrations of anti human parvovirus IgG than the patients with erythema infectiosum. " 11/01/1984 - "[Detection of anti-human parvovirus IgM and IgG in erythema infectiosum]."
5.	Viral DNAIBA 08/01/2007 - "Erythema infectiosum developed in two patients of group B on the 6th and 29th days after onset when the amount of viral DNA was similar to that in group A. " 12/01/2002 - "Because relatively small blood volumes are obtained in thumb prick blood samples, we compared the results of two different techniques during an outbreak of erythema infectiosum: the usual serological detection of IgM antibodies (ELISA) versus PCR-based detection of viral DNA. " 09/01/1988 - "Through the use of recently developed serologic tests, epidemics of erythema infectiosum and parvoviral infection have been related not only to aplastic crisis but also to intrauterine infection and hydrops; DNA hybridization studies have allowed the detection of viral DNA in serum and tissue extracts. "
6.	Tissue ExtractsIBA 09/01/1988 - "Through the use of recently developed serologic tests, epidemics of erythema infectiosum and parvoviral infection have been related not only to aplastic crisis but also to intrauterine infection and hydrops; DNA hybridization studies have allowed the detection of viral DNA in serum and tissue extracts. "
7.	AntibodiesIBA 08/10/1993 - "[Detection of antibodies in erythema infectiosum--now also possible in Norway]." 04/01/1990 - "[Seroprevalence of human parvovirus B 19 antibodies (Sticker's disease/erythema infectiosum) in the DRG population]." 11/19/1988 - "Treatment of one patient with plasma containing specific antibodies against parvovirus resulted in a transient fall in serum virus levels, the appearance of reticulocytes, and symptoms of fifth disease." 09/01/1996 - "Unlike erythema infectiosum, anti-HPV B19 antibodies seem to develop later after onset of the skin eruption and while viremia is still present." 11/01/1984 - "Detection of antibodies to human parvovirus in erythema infectiosum (fifth disease)."
8.	AntigensIBA 10/01/1995 - "We tested serum samples from the patients with erythema infectiosum and aplastic crisis by EIA kit with recombinant antigens synthesized in a baculovirus expression system (Denka Seiken Co., Tokyo, Japan). " 05/01/1995 - "A new recombinant parvovirus B19 antigen was tested whether it was responsive to human serum antibodies in every epidemic year of erythema infectiosum for 25 years, because wild strains of B19 parvovirus were changeable genetically. " 05/01/1988 - "In natural infections, B19 antigen and DNA have been detected in sera early in the course of aplastic crisis and only rarely in fifth disease. " 08/01/1990 - "An ELISA for detecting parvovirus B19 specific IgM and IgG was established using B19 viral particles as antigen derived from plasma of donors in the incubation phase of erythema infectiosum. " 05/01/2001 - "We used 80 sera collected from 58 erythema infectiosum and 6 transient aplastic crisis patients to test IgM and IgG antibodies against these two proteins in an immunofluorescence assay (IFA) using Sf9 cells infected with recombinant baculovirus expressing either VP1 or VP2 antigen. "
9.	Single-Stranded DNA (DNA, Single Stranded)IBA 07/01/2010 - "Human parvovirus B19 is a small, non-enveloped, icosahedral symmetric, single-stranded DNA virus that can cause a number of diseases, notably erythema infectiosum in children and aplastic crisis in patients with chronic hemolytic disorders. " 01/01/1989 - "The well-known condition of erythema infectiosum is caused by parvovirus B19, a single-stranded DNA virus discovered in 1975. " 05/09/2006 - "Human erythrovirus is a minute, single-stranded DNA virus causing many diseases, including erythema infectiosum, arthropathy, and fetal death. " 01/01/1996 - "Human parvovirus B19, discovered in 1974, is a single-stranded DNA virus which causes erythema infectiosum, arthralgia, aplastic crisis in patients with red cell defects, chronic anaemia in immunocompromised patients, and fetal hydrops. " 12/07/1984 - "The genome of the small human virus serologically associated with erythrocyte aplasia and erythema infectiosum (fifth disease) is shown to be a linear, nonpermuted, single-stranded DNA molecule with self-priming hairpin termini, properties which are characteristic of the genomes of the family Parvoviridae. "
10.	Immunoglobulins (Immunoglobulin)IBA 07/01/1996 - "Fifth disease after immunoglobulin administration in an AIDS patient with parvovirus-induced red cell aplasia." 07/01/1991 - "Antibodies of the immunoglobulin (Ig) M class were measured in serum samples from patients with erythema infectiosum and controls. " 08/01/1996 - "The patient presented with transient arthritis in the wrist, ankle joint and neck and elevation of immunoglobulin IgM antibodies to HPV B19 and rubella, antibodies to Mycoplasma and antistreptolysin O but without the typical clinical features of erythema infectiosum. "

Therapies and Procedures

1.	Transplants (Transplant) 11/01/2000 - "The infection caused prolonged anaemia, thrombocytopenia, arthralgia and erythema infectiosum in a 16-year-old girl with acute myeloid leukaemia receiving a BM transplant (BMT). "
2.	Day Care (Partial Hospitalization) 04/18/1990 - "During a large outbreak of erythema infectiosum in Connecticut, a survey was conducted on 571 (90%) of 634 school and day-care personnel to determine the risk of acquiring B19 infection. " 04/18/1990 - "Occupational risk of human parvovirus B19 infection for school and day-care personnel during an outbreak of erythema infectiosum."