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Arachidonic Acid (Vitamin F)

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An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.

Also Known As:

Vitamin F; (all-Z)-5,8,11,14-Eicosatetraenoic acid; Arachidonic Acid, (all-Z)-Isomer, 1-(14)C-Labeled; Arachidonic Acid, (all-Z)-isomer, 3H-Labeled; Arachidonic Acid, Ammonium Salt, (all-Z)-Isomer; Arachidonic Acid, Cerium Salt, (all-Z)-Isomer; Arachidonic Acid, Cesium Salt, (all-Z)-Isomer; Arachidonic Acid, Lithium Salt, (all-Z)-Isomer; Arachidonic Acid, Potassium Salt, (all-Z)-Isomer; Arachidonic Acid, Sodium Salt; Arachidonic Acid, Sodium Salt, (all-Z)-Isomer; Arachidonic Acid, Zinc Salt, (all-Z)-Isomer; Sodium Arachidonate; Arachidonate, Sodium; 5,8,11,14-Eicosatetraenoic acid, (all-Z)-

Networked: 4889 relevant articles (115 outcomes, 411 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 18571
- Fatty Acids: 6864
  - Unsaturated Fatty Acids: 3881

Experts

1.	Rapoport, Stanley I: 31 articles (12/2014 - 07/2002)
2.	Hammock, Bruce D: 18 articles (10/2014 - 04/2004)
3.	Calder, Philip C: 16 articles (09/2015 - 04/2003)
4.	Shuttleworth, Trevor J: 16 articles (02/2015 - 03/2003)
5.	Bazinet, Richard P: 14 articles (04/2010 - 05/2005)
6.	Thompson, Jill L: 13 articles (02/2015 - 03/2003)
7.	Zeldin, Darryl C: 13 articles (12/2014 - 11/2003)
8.	Rao, Jagadeesh S: 13 articles (08/2012 - 10/2005)
9.	Falck, John R: 12 articles (07/2015 - 07/2004)
10.	Chang, Lisa: 12 articles (08/2012 - 06/2003)

Related Diseases

1.	Inflammation 01/01/2003 - "A diet low in arachidonic acid ameliorates clinical signs of inflammation in patients with RA and augments the beneficial effect of fish oil supplementation." 01/01/1991 - "However, the drug was less effective in reducing conjunctival inflammation induced by 1% sodium arachidonate. " 09/01/2006 - "Because the clinical behavior of PAF parallels that of inflammation following surgery, we investigated the effect of the inflammatory mediator arachidonic acid on the electrical behavior of normal atrial tissue in vitro and assessed the efficacy of the topical application of anti-inflammatory drugs at suppressing PAF in an animal model. " 01/01/1995 - "Reduced production of arachidonic acid metabolites may also contribute to improvement in the bronchial inflammation." 10/01/2015 - "The study demonstrated that methanolic extract of Tulsi leaves can decrease inflammation in the cardiac tissue of ISP-induced MI in rats and its effect may be through downregulation of oxidative stress and arachidonic acid pathway. "
2.	Bipolar Disorder (Mania) 05/01/2008 - "Chronic administration to rats of mood-stabilizers that are effective against mania in bipolar disorder, is reported to downregulate markers of the brain arachidonic acid cascade. " 09/01/2007 - "These results are consistent with the hypothesis that drugs effective in treating the manic phase of bipolar disorder decrease brain arachidonic acid turnover." 11/01/2006 - "Assuming that stages of bipolar disorder are related to brain arachidonic acid metabolism, we hypothesized that drugs effective in depression would increase cPLA(2) activity. " 03/01/2015 - "Disturbances related to the arachidonic acid cascade and prostaglandin metabolism may be involved in the pathophysiology of bipolar disorder, as supported by a recent genome-wide association study meta-analysis; however, evidence from clinical studies on a transcriptional level is lacking. " 10/01/2009 - "Future basic and clinical studies on the arachidonic acid hypothesis of bipolar disorder are warranted."
3.	Edema 04/01/1999 - "All these compounds proved to be effective against 12-O-tetradecanoylphorbol-13-acetate-induced ear edema in mice, although lacking activity against arachidonic acid-induced edema. " 01/01/1993 - "The arachidonic acid (AA)-induced ear edema model in the mouse has been demonstrated as an effective in vivo experimental tool to screen compounds showing anti-inflammatory activity. " 01/01/2015 - "A final hit exhibited an improved efficacy in arachidonic acid-induced ear edema when applied topically but not orally. " 06/06/2002 - "In addition, the N-substituted tetrahydrophthalazinones under study were investigated for their in vivo antiinflammatory activities by examining the suppression of arachidonic acid (AA) induced mouse ear edema formation. " 06/20/2015 - "The topic anti-inflammatory effect was evaluated through mice ear edema induced by arachidonic acid (AA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) at a dose of 3 mg/ear. "
4.	Neoplasms (Cancer) 01/01/2012 - "Arachidonic acid and cancer risk: a systematic review of observational studies." 04/01/1996 - "Previous studies demonstrated a requirement for arachidonic acid metabolites in tumor development in mouse skin. " 03/01/1994 - "In this study, we analyzed the biosynthesis of mono HETEs from arachidonic acid in tumor cells of different metastatic ability and correlated biosynthesis to metastatic potential. " 01/01/1992 - "The studies described herein were undertaken with the objective of determining the effect of modulation of arachidonic acid metabolism on proliferation of rat mammary tumor cells in culture. " 01/01/1990 - "This suggests that the study of arachidonic acid metabolism may contribute to characterization of the primary cancer and lead to better understanding of the mechanisms of tumor growth and diffusion."
5.	Asthma (Bronchial Asthma) 12/01/1999 - "To assess whether the clinical efficacy of TXA2 antagonist is predictable on the basis of urinary arachidonic acid metabolites in urine of patients with asthma, an open and multicentre trial was conducted. " 01/01/2014 - "Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studies." 01/01/1984 - "[Experimental study on the significance of arachidonic acid metabolism in the pathogenesis of bronchial asthma with an in vivo model in the guinea pig]." 10/15/2014 - "Severe asthma is characterized by airway inflammatory responses associated with aberrant metabolism of arachidonic acid. " 04/01/2014 - "Arachidonic acid metabolites are implicated in the pathogenesis of asthma although only limited information is available on the impact of current smoking history on these metabolites. "

Related Drugs and Biologics

1.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
2.	Phospholipids
3.	Lithium
4.	Aspirin (Acetylsalicylic Acid)
5.	Collagen
6.	Carbamazepine (Tegretol)
7.	Fatty Acids (Saturated Fatty Acids)
8.	Indomethacin (Indometacin)
9.	Acids
10.	Calcium

Related Therapies and Procedures

1.	Oral Administration
2.	Ligation
3.	Sympathectomy (Sympathectomies)
4.	Microspheres (Microsphere)
5.	Vegetarian Diet (Vegetarianism)