Yin Deficiency (Yinxu)

In the YIN-YANG system of philosophy and medicine, an insufficiency of body fluid (called yinxu), manifesting often as irritability, thirst, constipation, etc. (The Pinyin Chinese-English Dictionary, 1979).

Also Known As:

Networked: 154 relevant articles (8 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Yang Deficiency (Xu, Yang)
2.	Erectile Dysfunction
3.	Stroke (Strokes)
4.	Reflex Sympathetic Dystrophy (Reflex Sympathetic Dystrophy Syndrome)
5.	Heart Failure

Experts

1.	Wang, Jie: 4 articles (08/2013 - 09/2008)
2.	Zhang, Bing: 4 articles (10/2012 - 12/2007)
3.	Yang, Wei: 3 articles (09/2014 - 07/2008)
4.	Su, Yi-Chang: 3 articles (01/2014 - 01/2012)
5.	Zhang, Ying: 3 articles (08/2013 - 11/2009)
6.	Jin, Rui: 3 articles (10/2012 - 01/2011)
7.	Li, Bo: 2 articles (05/2015 - 05/2014)
8.	Xia, Cheng-Dong: 2 articles (09/2014 - 07/2012)
9.	Wei, Zi-Xiao: 2 articles (09/2014 - 07/2012)
10.	Chen, Zhu-Hong: 2 articles (09/2014 - 07/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Yin Deficiency:

1.	vardenafil (Levitra)FDA Link 09/01/2010 - "Vardenafil is more effective for ED patients with kidney-yang or kidney-yin deficiency than for those with liver-qi stasis." 09/01/2010 - "[Clinical efficacy of vardenafil on ED patients with kidney-yang or -yin deficiency or liver-qi stasis]." 09/01/2010 - "To study the clinical efficacy of vardenafil on erectile dysfunction (ED) patients with kidney-yang deficiency, kidney-yin deficiency or liver-qi stasis. "
2.	TabletsIBA 10/01/2015 - "To investigate the safety and efficacy of Yangxinkang Tablets () in patients with chronic heart failure (CHF) and syndrome of qi and yin deficiency, blood stasis, and water retention. " 09/01/2003 - "To verify the therapeutic effects of the method of softening and lubricating the joints, and calming the endogenous wind in case of rheumatoid arthritis (RA) with the syndrome of channel blockage due to yin deficiency, 60 RA patients with the syndrome of channel blockage due to yin deficiency were randomly divided into a treatment group (40 cases) and a control group (20 cases) and treated respectively by the above method for the former and with Zheng Qing Feng Tong Ning Tablets ([symbol: see text]) for the latter. " 05/01/1993 - "[Diabetes mellitus of qi-yin deficiency type treated by hypoglycemic Chinese herbal tablets. "
3.	Paroxetine (Paxil)FDA LinkGeneric 04/01/2013 - "To explore the efficacy of jieyu granule (JG) combined Paroxetine in treating refractory depression (RD) patients of yin deficiency inner heat syndrome (YDIHS). " 04/01/2013 - "[Treatment of refractory depression patients of yin deficiency inner heat syndrome by jieyu granule combined paroxetine: an efficacy observation]."
4.	von Willebrand FactorIBA 11/01/1989 - "The results indicated the level of HDL-C was decreased, LDL-C was increased, ratio of HDL-C/TC was also decreased, platelet aggregation test (PAgT) was increased, factor VIII related antigen (VIII R: Ag) was elevated, among the above 3 types, especially in Yin deficiency group, showed statistically significant. "
5.	erdi biejiaIBA 12/01/2012 - "Erdi Biejia Decoction is efficacious in the treatment of ED with kidney-yin deficiency, with no obvious adverse effects." 12/01/2012 - "We equally randomized 60 ED patients with kidney-yin deficiency into a treatment and a control group, the former treated with oral Erdi Biejia Decoction, and the latter given placebo, for a course of 8 weeks. " 12/01/2012 - "To observe the clinical efficacy of the Chinese medicine Erdi Biejia Decoction in the treatment of erectile dysfunction (ED) with kidney-yin deficiency, and explore its action mechanism and the nourishing yin doctrine in the treatment of ED. " 12/01/2012 - "[Erdi Biejia decoction for erectile dysfunction with kidney-yin deficiency]."
6.	yishenIBA 09/01/2014 - "To assess the efficacy of Yishen Jiejing Decoction (YJD) in treating poststroke shoulder-hand syndrome (SHS) patients of yin deficiency yang hyperactivity with blood stasis stagnation collaterals syndrome. " 09/01/2014 - "[Efficacy assessment of treating post-stroke shoulder-hand syndrome patients of yin deficiency yang hyperactivity with blood stasis stagnation collaterals syndrome by yishen tongluo decoction]."
7.	Insulin (Novolin)FDA Link 08/01/2009 - "SQD can relieve the clinical symptoms in patients of syndrome of qi-yin deficiency and inner blockage of blood stasis, increase the insulin sensitivity and reduce the IR in patients, so as to decrease their FBG, blood pressure and HbAlc. " 11/01/2011 - "The insulin resistance index (IRI), insulin action index and body mass index (BMI) of patients in the Yin-Yang deficiency group were significantly different from those of patients with dryness-heat due to deficiency of yin and Qi-Yin deficiency. " 03/01/2012 - "To study the protection of Zibu Piyin Recipe (ZBPYR) on the insulin signal pathway in the hippocampus of Pi-yin deficiency diabetic encephalopathy rats and to explore its possible mechanisms. " 11/01/2006 - "Traditional Chinese herbs for nourishing yin to reduce fire can significantly reduce the serum levels of testosterone and insulin in PCOS women with syndrome of kidney yin deficiency, and herbs for invigorating spleen and replenishing qi can significantly reduce the serum level of insulin in PCOS women with syndrome of spleen qi deficiency." 11/01/2006 - "Among the 43 cases, 20 cases had high serum testosterone level, in which 13 cases with syndrome of kidney yin deficiency, 7 cases with syndrome of spleen qi deficiency, but the difference had no statistic significance; 17 cases had high serum insulin level, in which 11 cases with syndrome of spleen qi deficiency, 6 cases with syndrome of kidney yin deficiency, the difference had statistic significance (P<0.05). "
8.	DNA (Deoxyribonucleic Acid)IBA 04/01/2007 - "Arranged from low to high, the percentages of CHB patients with the serum HBV-DNA > or = 1.0 x l0(5) copy/mL (high viral loading) in the five syndrome types were as follows: damp-heat retention in middle-jiao syndrome (DHRS, 55.2%), blood stasis blocking collateral syndrome (BSBC), Gan-Shen yin deficiency syndrome (GSYS), Pi-Shen yang deficiency syndrome (PSDS) and Gan stagnation with Pi deficiency syndrome (GSPS, 82.5%), the difference was significant between DHRS and GSPS; those with HBV-DNA in PBMCs infection were: GSYS (27.3%), DHRS (34.3%), BSBC (53.1%) and GSPS (77.2%). " 04/01/2013 - "The purpose of this study was to explore the effects of Erzhi Tiangui Granule (ETG) on DNA methyltransferases (DNMT) 1 protein expression in endometrium of infertile women with Kidney-yin Deficiency syndrome. " 09/01/2005 - "One hundred and two patients with chronic hepatitis with positive HBV DNA and hadn't ever been treated by Lamivudine and interferon were differentiated according TCM syndrome differentiation into 5 types, two excess types (damp-heat blocking zhong-jiao type and blood stasis blocking collaterals type) and three deficiency types, gan-stagnation with pi-dificiency type, gan-shen yin-deficiency type and pi-shen yang-deficiency type. " 01/01/1992 - "75.5% cases of Gan-Shen Yin-Xu (deficiency of Yin of the liver and kidney) type belonged to chronic active hepatitis (CAH) and 88.5% of the cases were pathologically described as CAH, the positive rates of HBeAg and/or HBV DNA in serum and HBsAg in liver tissues were all 80.8%, among which the diffuse pattern of HBsAg accounted for 85.7%, which was higher than that in Gan-Yu Pi-Xu type (P less than 0.05), the positive rates of HBcAg and HBV DNA in liver tissues were 34.6% (of which 55.6% appeared cytoplasmic pattern) and 63.2% respectively, which was higher than that in Gan-Yu Pi-Xu type (P less than 0.05). "
9.	Urea (Carbamide)FDA LinkGeneric 03/01/2006 - "The levels of 24 h urinary protein, serum creatinine and urea nitrogen in patients with Pi-Fei qi asthenia syndrome, qi-yin deficiency syndrome and Gan-Shen yin asthenia syndrome were significantly lower than those in patients with Pi-Shen yang asthenia syndrome, respectively (P < 0.05), while the blood pressure in patients with Pi-Fei qi asthenia syndrome, and qi-yin deficiency syndrome were significantly lower than that in patients with Gan-Shen yin asthenia syndrome and Pi-Shen yang asthenia syndrome (P<0.01). " 04/01/1984 - "[Study on pathological basis of yang-deficiency and yin-deficiency in patients with chronic nephritis by urinary analysis of creatinine, urea, potassium, phosphorus and magnesium]." 04/01/2015 - "Kidney-Yang deficiency [Shenyangxu (SYAX)] and liver-kidney-Yin deficiency (Ganshenyinxu) are patterns of symptoms in Traditional Chinese Medicine that were set as covariates, along with age, height, blood urea nitrogen, serum creatinine, alanine transaminase, aspartate transaminase, and hyperlipidemia. "
10.	Atrial Natriuretic Factor (ANF)IBA 10/01/2004 - "In CHF patients with edema and blood stasis Syndrome type, the level of plasma ANP was significantly higher than that in the control group (P < 0.05); level of T3 was significantly lower than that in the control group and in CHF patients of other three (Xin-qi deficiency, Yin-deficiency and blood stasis) Syndrome groups (P < 0.01, P < 0.01, P < 0.05 and P < 0.01); levels of LVEF and mVcf were significantly lower than those in the other three Syndrome groups (all P < 0.01). " 05/01/2004 - "As compared the indexes between the typical and the non-typical Yin-deficiency groups, significant difference only showed in plasma aldosterone and ANP, which was significantly higher in the former (P < 0.05, P < 0.01). " 11/01/1991 - "In order to study the connection of diastolic activity of smooth muscles of blood vessels with development of hypertension, plasma cAMP, cGMP, TXB2, 6-K-PGF1 alpha, ANP, SP were determined with radioimmunoassay, of 173 hypertension patients with Liver Yang exuberance (LYE) 91 cases, and Yin deficiency and Yang exuberance (YDYE) 82 cases. "

Therapies and Procedures

1.	Aftercare (After-Treatment) 08/01/2014 - "After treatment, the total effective rate was 84.8% (95/112), in which the efficacy on the stasis predominated syndrome was better than that of yin deficiency predominated syndrome [92.9% (52/56) vs 76.8% (43/56), P < 0.05]. " 06/01/1990 - "After treatment (2-month course), the clinical improvement rates in 38 cases of the Gan-Yu Pi-Xu type and in 26 cases of the Gan-Shen Yin-Xu type were 92.1% and 88.5% respectively, more effective than that of the control group (P less than 0.05). " 07/01/2008 - "High expression manners of Fn and FL were shown in all CAA patients, the high expressions of both were lowered to some extent after treatment, but the improvement in the test group was better than that in the control group (P <0.05), and the deviation was more liable to be corrected in patients of Shen-yang deficiency type than that in patients of Shen-yin deficiency type. " 09/01/2014 - "Both groups got improvement in neurologic impairment, stroke induced blood stasis syndrome, yin deficiency yang hyperactivity syndrome, and the improvement of upper limbs movement after treatment (all P < 0.05). " 03/01/2009 - "After treatment, the body weight, BMI, circumferences of waist and hip in the 5 groups had significant changes; the total effective rates in the group of dampness stagnancy due to spleen deficiency, the stomach heat-dampness stagnation group, the group of stagnation of liver qi, the group of deficiency of both spleen and kidney deficiency, the group of endogenous heat due to yin deficiency were 83.3%, 93.3%, 48.2%, 69.2% and 41.70%, respectively. "
2.	Moxibustion 08/01/2013 - "Questionnaire contents consist of overview, pathogeny, diagnosis standard, dialectical medication (phlegm heat resistance pulmonary lung and kidney Yin deficiency lung spleen-deficiency), treating spleen-deficiency (lung), moxibustion treatment and aftercare care and diet and mental, average (2.93-3.00), full mark rate (93.10%-100%) ranks average (9.91-10.67) and (287.50-309.50) of which are the most high value, and the variation coefficient is 0.00, the Kendall coefficient (Kendalls W) is 0.049 which is statistical significance, the questionnaire reliability value of alpha was 0.788. " 06/01/2013 - "Following the treatment, the skin lesion score and yin-deficiency constitution score were significantly decreased in comparison with pre-treatment in the same one group (P < 0.05), and those of the moxibustion group were remarkably lower than those of the control group (P < 0.05). " 06/01/2013 - "Suspended moxibustion is effective in improving both skin lesion and yin-deficiency constitution in acne patients with yin-deficiency-inner heat type." 07/01/2005 - "The study on relation of the difference of the left and right axillary temperature with constitution types and diagnosis of diseases proves that the temperature of the left and right axillary is correlated with excess and insufficiency of Yin and Yang, namely, higher left axillary temperature is recognized as Yin-deficiency and Yang-excess, and higher right axillary temperature as Yang-deficiency and Yin-excess, and this can guide clinical syndrome differentiation treatment of acupuncture and moxibustion and individual diagnostic and therapeutic program can be established based on this." 06/01/2013 - "To observe the clinical effect of moxibustion therapy for 29 cases of yin-deficiency type acne. "
3.	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/01/2007 - "This study describes development and validation of a questionnaire as an adjunct to Traditional Chinese Medicine diagnosis of Yin-Deficiency Syndrome (Yin-DS). " 08/01/2015 - "A total of 16 yin-deficiency constitution volunteers (9 woman and 6 men) from 200 students of Fujian University of Traditional Chinese Medicine finished a body constitution questionnaire and showed a yin-deficiency constitution. " 01/01/2015 - "Baihe Zhimu Tang (BZT) is a famous traditional Chinese medicine recipe to treat dry coughing due to yin deficiency and for moisturizing the lungs. " 09/01/2014 - "Fifty-five patients had the traditional Chinese medicine (TCM) syndrome of Qi-Yin deficiency, about 14.78% of the whole. " 01/01/2014 - "In Chinese medicine, diabetes belongs to the category of "Xiaoke disease (disease with symptoms of frequent drinking and urination)"; in the traditional sense, its pathogenesis is "Yin deficiency and dryness-heat." However, over time, changes in the social environment and lifestyle have also changed the use of traditional Chinese medicine (TCM) in diabetes. "
4.	Drug Therapy (Chemotherapy) 01/01/2012 - "The symptoms of qi and yin deficiency are similar to chemotherapy- or radiotherapy-induced side effects. " 01/01/2013 - "There were significant increases in yang-xu, yin-xu, and yu at 1 month and 3 months after than before the start of the chemotherapy, target, or combined therapy. " 04/01/2008 - "Sixty patients with advanced lung cancer of qi-yin deficiency syndrome were randomized into three groups: the TCM group (A) treated with YYJD, the chemotherapy group (B) treated by chemotherapy with NP or GP protocol, and the combined treated group (C) treated with YYJD and chemotherapy in combination. "
5.	Meridians (Jing Luo) 10/01/2012 - "The total effective rate of the excessive syndrome [hyperactivity of liver yang and blood stagnation in meridians and collaterals, 100% (40/40)] was better than that of the deficiency syndrome [kidney yin deficiency and qi and blood deficiency, 87.5% (35/40)] (P < 0.05). " 12/01/2012 - "The Chinese herbal medicine therapy included No. 1 stroke formula for the cases of liver and kidney yin deficiency and the upward disturbance of wind yang, No. 2 stroke formula for qi deficiency and blood stagnation, and the stagnation in meridians and No. 3 stroke formula for the interaction of phlegm and stasis and blockage of meridians according to the pattern/syndrome differentiation. "