gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)

T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3).

Also Known As:

T-Cell Receptor delta-Chain; T-Cell Receptor gamma-Chain; Receptors, Antigen, T-Cell, gamma-delta; Antigen T Cell Receptor, delta Chain; Antigen T Cell Receptor, gamma Chain; Receptors, Antigen, T Cell, gamma delta; T Cell Receptors, gamma delta; T-Cell Receptor, gamma-delta; T Cell Receptor delta Chain; T Cell Receptor gamma Chain; T Cell Receptor, gamma delta; T Cell Receptors delta Chain; T Cell Receptors gamma Chain; TcR gamma delta; delta-Chain, T-Cell Receptor; delta-Chain, T-Cell Receptors; gamma-Chain, T-Cell Receptor; gamma-Chain, T-Cell Receptors; gamma-delta T-Cell Receptor; gamma-delta T-Cell Receptors; gamma-delta, TcR; Antigen Receptors, T-Cell, gamma-delta; T-Cell Receptors delta-Chain; T-Cell Receptors gamma-Chain; T-Cell Receptors, gamma-delta; TcR gamma-delta

Networked: 474 relevant articles (8 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Antigen Receptors: 740
        T-Cell Antigen Receptors: 7312
        gamma-delta T-Cell Antigen Receptors: 474
        human T-cell receptor Vdelta2
        human T-cell receptor Vgamma9
        human TCRVgamma9 protein
        mouse T-cell receptor Vgamma6
        T-cell receptor V(gamma)3

Experts

1.	Medeiros, L Jeffrey: 3 articles (03/2017 - 04/2002)
2.	Stetler-Stevenson, Maryalice: 2 articles (04/2010 - 09/2005)
3.	Jones, Dan: 2 articles (02/2008 - 10/2002)
4.	Hummel, Michael: 2 articles (05/2005 - 07/2002)
5.	Stein, Harald: 2 articles (05/2005 - 07/2002)
6.	Cheng, Wing-Shing: 2 articles (08/2004 - 08/2003)
7.	Essand, Magnus: 2 articles (08/2004 - 08/2003)
8.	Pastan, Ira: 2 articles (06/2004 - 08/2003)
9.	Burg, G: 2 articles (01/2002 - 01/2000)
10.	Essand, M: 2 articles (11/2001 - 08/2000)

Related Diseases

1.	Infections 11/24/1997 - "The gamma delta TCR -/- mice cleared infection just like control mice. " 06/02/1997 - "Thus, this study demonstrates that TCR-gamma/delta cells may play an important regulatory role in human HSV-1 infections." 10/01/1996 - "Recent studies in man and animal models have demonstrated that TCR-gamma delta-bearing T cells (gamma delta T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. " 12/01/2008 - "Characteristics of circulating T cell receptor gamma-delta T cells from individuals chronically infected with hepatitis B virus (HBV): an association between V(delta)2 subtype and chronic HBV infection." 05/01/2005 - "Among mononuclear BALF-cell populations, the gamma/delta TCR-expressing cells showed a pronounced transient increase in proportion as well as in relative cell size 2 weeks post primary infection, whereas CD4-, CD8-, Ig- and CD14-expressing cells showed no significant differences related to the infection. "
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/01/1992 - "The current study was designed to determine the nucleotide sequence of two distinct T-cell-receptor delta chain (TCR delta) rearrangements which account for 95% of all rearranged alleles in common non-T, non-B lymphoid precursor acute lymphoblastic leukemia (LP-ALL). " 05/01/1991 - "Detection of T-cell receptor gamma chain V gene rearrangements using the polymerase chain reaction: application to the study of clonal disease cells in acute lymphoblastic leukemia." 01/01/2019 - "Treatment response and outcome of children with T-cell acute lymphoblastic leukemia expressing the gamma-delta T-cell receptor." 08/01/1995 - "Detection of neoplastic clone in the hypoplastic and recovery phases preceding acute lymphoblastic leukemia by in vitro amplification of rearranged T-cell receptor delta chain gene." 02/01/1993 - "Human T-cell lymphoblastic lymphoma expressing the T-cell receptor gamma/delta established in immune-deficient (bg/nu/xid) mice."
3.	Leukemia 01/01/2004 - "T cell receptor delta-chain gene rearrangement in a novel case of adult NK cell leukemia." 04/01/1998 - "Importance of T-cell receptor delta-chain gene analysis on CD7+ and CD56+ myeloid/natural killer cell precursor acute leukemia." 01/01/1995 - "These findings suggest that monoclonal proliferation of TCR gamma delta-positive granular lymphocytes (GL) can be associated with PRCA even in a patient having a small proportion of leukemia GL, which we propose to designate as 'smoldering GLL'." 09/01/1994 - "Rearrangement of the T-cell receptor delta chain (TCRD) gene at 14q11 was demonstrated in the three cases studied, suggesting its involvement in the pathogenesis of these leukemias by alteration of the structure or expression of an unidentified gene(s) on the long arm of chromosome 5." 02/01/1991 - "Limited combinatorial repertoire of gamma delta T-cell receptors expressed by T-cell acute lymphoblastic leukemias."
4.	Residual Neoplasm 05/01/2006 - "Results show that both aGVHD and minimal residual disease (MRD) eradication did significantly affect TCR gamma/delta profile. " 02/01/2006 - "Further treatment strategy was then adapted according to minimal residual disease monitoring by immunophenotypic and T-cell receptor gamma chain gene evaluation. " 04/01/2000 - "Currently, at 24 months post BMT, there has been no evidence of minimal residual disease (MRD) detected by polymerase chain reaction (PCR) assay for the T-cell receptor gamma chain gene. " 04/01/2002 - "PCR-heteroduplex analysis of TCR gamma, delta and TAL-1 deletions in T-acute lymphoblastic leukemias: implications in the detection of minimal residual disease." 02/01/1992 - "Extensive junctional diversity of gamma delta T-cell receptors expressed by T-cell acute lymphoblastic leukemias: implications for the detection of minimal residual disease."
5.	Virus Diseases (Viral Diseases) 06/02/1997 - "However, a direct role for TCR-gamma/delta cells in protective immunity for pathogenic viral infection has not been demonstrated. " 02/15/1992 - "These data suggest that TCR-gamma delta lymphocytes may play an important role in the immune response to viral infections." 03/01/1991 - "These results oppose the view that lymphocytes expressing TcR gamma/delta predominate in initial epithelial immune responses to viral infections." 06/01/1997 - "Anti-type 2 T cells, generated in the spleens of thermally injured mice following the appearance of burn-associated CD8+, CD11b+, TCR gamma/delta + type 2 T cells (BA2T cells), have previously been shown to improve the resistance of thermally injured mice to Herpes virus infections. " 02/01/1996 - "In vivo treatment of mice with anti-alpha beta T cell receptor (TCR) antibody during the course of viral infection abrogated the response, suggesting that the virus-specific CTL were cells that express the alpha beta rather than gamma delta TCR. "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)
3.	Immunoglobulin A (IgA)
4.	Thomsen-Friedenreich antibodies
5.	Complementarity Determining Regions (Complementarity Determining Region)
6.	Oligonucleotides
7.	T-Cell Antigen Receptors (T-Cell Receptor)
8.	alpha-beta T-Cell Antigen Receptors (T-Cell Receptor alpha-Chain)
9.	Antigens
10.	gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)

Related Therapies and Procedures

1.	Stem Cell Transplantation
2.	Drug Therapy (Chemotherapy)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Transplantation
5.	Immunotherapy