Monocrotaline

A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.

Also Known As:

Networked: 889 relevant articles (55 outcomes, 146 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Weissmann, Norbert: 21 articles (09/2014 - 01/2004)
2.	Seeger, Werner: 20 articles (07/2014 - 01/2004)
3.	Grimminger, Friedrich: 17 articles (09/2013 - 01/2004)
4.	Humbert, Marc: 12 articles (10/2015 - 12/2009)
5.	Schermuly, Ralph T: 12 articles (09/2014 - 01/2004)
6.	Schermuly, Ralph Theo: 11 articles (09/2013 - 04/2004)
7.	Eddahibi, Saadia: 10 articles (02/2015 - 05/2003)
8.	Kadowitz, Philip J: 10 articles (10/2014 - 02/2007)
9.	Ghofrani, Hossein Ardeschir: 10 articles (09/2013 - 04/2004)
10.	Adnot, Serge: 9 articles (03/2015 - 05/2003)

Related Diseases

1.	Pulmonary Hypertension (Ayerza Syndrome) 11/01/2006 - "This study showed that increased expression of PCI in the lung is protective against monocrotaline-induced pulmonary hypertension, suggesting a potential beneficial effect of PCI for the therapy of this disease." 01/01/2015 - "Salvia Miltiorrhiza Bge.f.alba Ameliorates the Progression of Monocrotaline-Induced Pulmonary Hypertension by Protecting Endothelial Injury in Rats." 10/15/2014 - "Intratracheal administration of cyclooxygenase-1-transduced adipose tissue-derived stem cells ameliorates monocrotaline-induced pulmonary hypertension in rats." 09/01/2009 - "We tested whether CBDL ameliorates monocrotaline (MCT)-induced pulmonary hypertension (PH) in rats. " 12/01/2004 - "We investigated whether CNP ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats. "
2.	Anoxia (Hypoxia) 08/15/2013 - "We used loss and gain of function in vivo studies to establish the role and determine the therapeutic effect of endothelial IDO in hypoxia-induced PH in mice and monocrotaline-induced PH in rats. " 06/01/2012 - "In both hypoxia and monocrotaline-induced PAH rat models, which display reduced levels of bmpr2 transcripts, this study further indicates that the TGFβ-MAPK axis is activated in lungs following elevation of both expression and phosphorylation of the TAK1 protein. " 07/01/2010 - "The present study found that Smurf1 was significantly elevated in pulmonary arteries of monocrotaline and hypoxia-induced PAH rats. " 05/01/2004 - "The present study was carried out to explore if there are temporal alterations in HIF-1alpha levels during prolonged hypoxia and after monocrotaline (MCT) treatment. " 01/01/1996 - "This study was performed to test whether monocrotaline (MCT)-induced early airway dysfunction and gas exchange abnormalities result in arterial hypoxemia. "
3.	Right Ventricular Hypertrophy 01/10/2015 - "Intravenous administration of BPS-NP (once per week, 20μg/kg) protected against monocrotaline-induced pulmonary arterial remodeling and right ventricular hypertrophy. " 03/01/2013 - "The mean pulmonary arterial pressure, right ventricular hypertrophy, pulmonary vascular remodeling index, content of apelin protein in lung tissue of monocrotaline group were higher than those in control group. " 02/01/2013 - "In vivo, RAGE inhibition in monocrotaline- and Sugen-induced PAH demonstrates therapeutic effects characterized by PA pressure and right ventricular hypertrophy decrease (control rats have an mPAP around 15 mm Hg, PAH rats have an mPAP >40 mm Hg, and with RAGE inhibition, mPAP decreases to 20 and 28 mm Hg, respectively, in MCT and Sugen models). " 04/15/2012 - "Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline." 04/01/2012 - "The pulmonary arterial pressure (PAP) started to increase at least 7 days after monocrotaline injection, and the rats developed severe PAH in 21 days with high PAP, right ventricular hypertrophy and neointimal formation. "
4.	Hypertrophy 02/01/2010 - "The aim of the present study was to investigate the protective effects of RSV against monocrotaline (MCT)-induced right ventricular (RV) hypertrophy in rats. " 01/01/2015 - "In rats with monocrotaline-induced PAH, PTU therapy improved pulmonary arterial hypertrophy and hemodynamics. " 01/01/2016 - "This study aimed to evaluate the effects of rhNRG-1 in RV function and pulmonary vasculature in monocrotaline (MCT)-induced PAH and RV hypertrophy (RVH). " 07/01/1992 - "In the present study, we measured and characterized pulmonary artery (PA) elastolytic activity at time points before as well as coincident with the progression of medial hypertrophy in monocrotaline-injected adult male Sprague-Dawley rats. " 09/15/2015 - "Finally, we demonstrated that restoring the expression of miR-223 in lungs of rats with monocrotaline-induced PAH reversed established PAH and provided beneficial effects on vascular remodeling, pulmonary resistance, right ventricle hypertrophy, and survival. "
5.	Cardiomegaly (Heart Hypertrophy) 03/22/2011 - "Chronic nebulization of PDE3/4 inhibitor significantly attenuated monocrotaline-induced hemodynamic, gas exchange abnormalities, vascular remodeling, and right heart hypertrophy. " 09/02/2005 - "Since mechanical stress plays an important role in transcriptional regulation of a gene involved in cardiac hypertrophy and remodeling, we generated left-sided or right-sided pressure-overload models by transverse aortic constriction (TAC) in ddY mice or by monocrotaline administration in Wistar rats, respectively. " 01/01/2005 - "Monocrotaline injection provoked severe PAH (right ventricular systolic pressure increased from 25.9 +/- 4.0 to 68.9 +/- 3.2 after 4 weeks and 74.9 +/- 5.1 mmHg after 6 weeks), cardiac output depression and right heart hypertrophy. " 04/30/2004 - "When chronically infused from days 14 to 28, both agents significantly attenuated all monocrotaline-induced hemodynamic and gas exchange abnormalities as well as right heart hypertrophy. " 12/01/1999 - "We also examined the modulation of these NPRs during cardiac hypertrophy induced by monocrotaline (MCT). "

Related Drugs and Biologics

1.	rho-Associated Kinases
2.	sildenafil (Viagra)
3.	Idiopathic pulmonary hypertension
4.	Epoprostenol (Prostacyclin)
5.	fasudil (AT 877)
6.	Pravastatin (Pravachol)
7.	Estradiol (Estrace)
8.	prostacyclin synthetase (prostacyclin synthase)
9.	Heme Oxygenase-1
10.	GTP Phosphohydrolases (GTPases)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Oral Administration
3.	Ligation
4.	Intraperitoneal Injections
5.	Pneumonectomy (Lung Volume Reduction)