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NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)

Subscribe to New Research on NAD(P)H Dehydrogenase (Quinone)

A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.

Also Known As:

Quinone Reductase; Diaphorase, DT; Reductase, Menadione; Reductase, Phylloquinone; Reductase, Quinone; Reductase, Vitamin K; DT Diaphorase; Menadione Reductase; Phylloquinone Reductase; Vitamin K Reductase; NAD(P)H:(quinone-acceptor) oxidoreductase

Networked: 338 relevant articles (5 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - NADPH Oxidoreductases NADH
      - Quinone Reductases: 6
        NAD(P)H Dehydrogenase (Quinone): 338
        zeta-Crystallins: 12
        human CBR4 protein
        human NQO1 protein
        mouse Nqo1 protein
        rat NQO1 protein

Experts

1.	Pezzuto, John M: 26 articles (07/2015 - 05/2002)
2.	Kinghorn, A Douglas: 18 articles (08/2013 - 05/2002)
3.	Fong, Harry H S: 16 articles (02/2011 - 09/2002)
4.	Su, Bao-Ning: 10 articles (12/2006 - 09/2002)
5.	Park, Eun Jung: 10 articles (08/2004 - 09/2002)
6.	Mesecar, Andrew D: 9 articles (02/2011 - 09/2002)
7.	Jang, Dae Sik: 8 articles (08/2006 - 10/2002)
8.	Kang, Young-Hwa: 8 articles (08/2006 - 05/2003)
9.	Graham, James G: 8 articles (02/2004 - 10/2002)
10.	Vigo, Jose Schunke: 8 articles (02/2004 - 10/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1997 - "Thus, we suggested that the antitumor efficacy of bioreductive agents can be enhanced by selective induction of DT-diaphorase in tumor cells compared with normal cells. " 09/15/2015 - "In this study, we designed and synthesized substituted hexa-2,4-diyne-1,6-diols, more structurally simplified, tunable, and easily preparable than natural gymnasterkoreaynes, and evaluated their cancer chemopreventive activities by measuring concentration of doubling quinone reductase activity (CD), cell viability, and chemopreventive index (CI). " 03/14/2002 - "As a result of this study, it will be possible to design poor to excellent substrates of DT-diaphorase and take advantage of varying levels of this enzyme in histologically different cancers." 10/12/1995 - "In this study, we investigated whether DOX could selectively induce DT-diaphorase in tumor cells and whether combining this agent with MMC in an appropriate schedule could produce synergistic antitumor activity. " 09/01/1995 - "The present study examined nine cultured human non-cancerous fibroblast cell strains, five of which were from members of a single cancer-prone family, which demonstrated widely varying activity levels of DT-diaphorase (41 - 3462 nmol min-1 mg-1 protein), to determine if genetic alteration of the NQO1 or NOQ2 gene was involved in determining enzyme activity. "
2.	Colonic Neoplasms (Colon Cancer) 12/06/1995 - "Re: Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer." 07/05/1995 - "Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer." 06/01/1993 - "The cell lines used were the HCT 116 human colon cancer cell line and a MMC-resistant subline (HCT 116-R30A) that has 5% of the quinone reductase activity present in the parent cell line. " 08/10/2000 - "The naphthoquinones were toxic to both HT-29 and BE human colon cancer cell lines in a clonogenic assay; however, cytotoxicity did not correlate with DT-diaphorase activity in these cell lines. " 12/01/1998 - "The importance of DT-diaphorase in mitomycin C resistance in human colon cancer cell lines."
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/25/2001 - "A saturating relationship exists between the substrate specificity for human recombinant DT-diaphorase and the cytotoxicity in the human H460 non-small-cell lung cancer cell line. " 11/15/1993 - "Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma." 01/01/2004 - "The importance of DT-diaphorase and hypoxia in the cytotoxicity of RH1 in human breast and non-small cell lung cancer cell lines." 10/15/1994 - "DT-diaphorase as a determinant of sensitivity to adriamycin in non-small-cell lung-cancer cell lines." 09/01/2003 - "The antitumour efficacy of RH1 and MeDZQ has been studied in 4 human xenografts (3 non-small cell lung cancer and 1 colon cancer), and compared to the level of constitutive DT-Diaphorase activity measured by the DCPIP assay. "
4.	Inflammation 03/01/2010 - "DT-diaphorase activity in group II was significantly higher than that in group III. The histopathological results showed multiple numbers of newly formed bile ductules with inflammatory cells infiltration in group II. These pathological changes were improved in group III. Our data indicate that RO ameliorates hepatic injury, inflammation, lipid peroxidation and increases antioxidant enzymes activity in rats subjected to BDL. " 08/01/2006 - "Newly described antioxidant proteins include a soluble NADPH quinone reductase (MdaB) and an iron sequestering protein (NapA) that has dual roles - host inflammation stimulation and minimizing reactive oxygen species production within H. "
5.	Hepatocellular Carcinoma (Hepatoma) 11/01/2000 - "In this study, we show that watercress extracts are potent inducers of quinone reductase (QR) in murine hepatoma Hepa 1c1c7 cells, a widely adopted assay for measuring phase II enzyme induction. " 08/23/2013 - "Also, the quinone reductase induction activities of the isolates were determined using the Hepa 1c1c7 murine hepatoma cell line. " 03/23/2011 - "A murine hepatoma (Hepa 1c1c7) cellular bioassay was used to guide the isolation of phase II enzyme inducers from fermented soy sauce, using quinone reductase (QR) as a biomarker. " 08/01/2005 - "However, the extract had both DT-diaphorase inducing activity in the murine hepatoma (Hepa1c1c7) cell line and antimutagenic properties towards chemical-induced mutation in Salmonella typhimurium strains TA98 and TA100. " 09/01/2003 - "The potential of the isolates and chemical transformation products to induce quinone reductase was evaluated in mouse Hepa lclc7 hepatoma cells."

Related Drugs and Biologics

1.	Enzymes
2.	Glutathione Transferase (Glutathione S-Transferase)
3.	Mitomycin (Mitomycin-C)
4.	Cytochromes
5.	Porfiromycin
6.	Mixed Function Oxygenases (Monooxygenases)
7.	2,5- dimethyl- 3,6- diaziridinyl- 1,4- benzoquinone
8.	NAD (NADH)
9.	Aromatase (CYP19)
10.	apaziquone (E 09)

Related Therapies and Procedures

1.	Chemoprevention
2.	Heterologous Transplantation (Xenotransplantation)
3.	Drug Therapy (Chemotherapy)
4.	Radiotherapy
5.	Lasers (Laser)