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NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)

A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
Also Known As:
Quinone Reductase; Diaphorase, DT; Reductase, Menadione; Reductase, Phylloquinone; Reductase, Quinone; Reductase, Vitamin K; DT Diaphorase; Menadione Reductase; Phylloquinone Reductase; Vitamin K Reductase; NAD(P)H:(quinone-acceptor) oxidoreductase
Networked: 444 relevant articles (15 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Pezzuto, John M: 29 articles (10/2018 - 05/2002)
2. Kinghorn, A Douglas: 18 articles (08/2013 - 05/2002)
3. Fong, Harry H S: 16 articles (02/2011 - 09/2002)
4. Su, Bao-Ning: 10 articles (12/2006 - 09/2002)
5. Park, Eun Jung: 10 articles (08/2004 - 09/2002)
6. Kondratyuk, Tamara P: 9 articles (10/2018 - 04/2010)
7. Mesecar, Andrew D: 9 articles (02/2011 - 09/2002)
8. Jang, Dae Sik: 8 articles (08/2006 - 10/2002)
9. Kang, Young-Hwa: 8 articles (08/2006 - 05/2003)
10. Graham, James G: 8 articles (02/2004 - 10/2002)

Related Diseases

1. Carcinogenesis
2. Neoplasms (Cancer)
3. Inflammation (Inflammations)
03/01/2010 - "DT-diaphorase activity in group II was significantly higher than that in group III. The histopathological results showed multiple numbers of newly formed bile ductules with inflammatory cells infiltration in group II. These pathological changes were improved in group III. Our data indicate that RO ameliorates hepatic injury, inflammation, lipid peroxidation and increases antioxidant enzymes activity in rats subjected to BDL. "
01/01/2018 - "garrettii led to the isolation of twenty-one chemical ingredients, which were further evaluated for their inhibitions on oxidative stress and inflammation using NAD(P)H:quinone reductase (QR) assay and nitric oxide (NO) production assay. "
04/01/2018 - "Since QU has been shown to be effective in reducing inflammation and oxidative stress in various disease models, we hypothesized that the postnatal QU treatment of newborn mice will protect against hyperoxic lung injury by the upregulation of the phase I (CYP1A/B) and/or phase II, NADPH quinone reductase enzymes. "
10/01/2018 - "Nuclear factor-erythroid-2-related factor 2 (Nrf2) signaling is known to effectively inhibit inflammation, the present study found that resveratrol reduced the lipopolysaccharide-induced inflammatory response in kidney cells in vitro and induced the activation of Nrf2 signaling, including accumulation of nuclear Nrf2 and increase of the expression of Nrf2 target genes heme oxygenase (HO)-1 and NAD(P)H dehydrogenase (quinone) 1 (NQO1); this was confirmed by the induction of the expression of HO-1 and NQO1 by treatment of resveratrol in vitro and in vivo. "
01/01/2022 - "They were evaluated in several assays related to oxidative stress and inflammation (monoamine oxidases, nuclear erythroid 2-related factor, quinone reductase-2, and oxygen radical trapping) and then in experiments of increasing complexity (neurogenic properties and neuroprotection vs okadaic acid). "
4. Colonic Neoplasms (Colon Cancer)
5. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)

Related Drugs and Biologics

1. Enzymes
2. Transferases
3. NAD (NADH)
4. Glutathione Transferase (Glutathione S-Transferase)
5. Antioxidants
6. Uridine Diphosphate (UDP)
7. NADP (NADPH)
8. Glutathione (Reduced Glutathione)
9. Mitomycin (Mitomycin-C)
10. Estrogen Receptors

Related Therapies and Procedures

1. Chemoprevention
2. Oral Administration
3. Drug Therapy (Chemotherapy)
4. Precision Medicine
5. Therapeutics