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Apolipoprotein A-I (Apolipoprotein A1)

The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
Also Known As:
Apolipoprotein A1; Apo A-I; Apolipoprotein AI; Apo A-1; ApoA-I; Apo A-I Isoproteins; Apo A1; Apo AI; ApoA-1; Apolipoprotein A-1; Apolipoprotein A-I Isoprotein-2; Apolipoprotein A-I Isoprotein-4; Apolipoprotein A-I Isoproteins; Apolipoprotein AI Propeptide; Pro-Apo A-I; Pro-Apolipoprotein A-I; Proapolipoprotein AI; Apo A I Isoproteins; Apolipoprotein A 1; Apolipoprotein A I; Apolipoprotein A I Isoprotein 2; Apolipoprotein A I Isoprotein 4; Apolipoprotein A I Isoproteins; Pro Apo A I; Pro Apolipoprotein A I
Networked: 3926 relevant articles (164 outcomes, 573 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Fogelman, Alan M: 42 articles (01/2022 - 01/2002)
2. Navab, Mohamad: 38 articles (01/2022 - 01/2002)
3. Rye, Kerry-Anne: 38 articles (01/2022 - 06/2004)
4. Vuilleumier, Nicolas: 36 articles (10/2022 - 12/2004)
5. Anantharamaiah, G M: 35 articles (05/2020 - 03/2001)
6. Reddy, Srinivasa T: 34 articles (01/2022 - 09/2003)
7. Pagano, Sabrina: 30 articles (10/2022 - 04/2010)
8. Remaley, Alan T: 30 articles (01/2021 - 04/2003)
9. Rader, Daniel J: 28 articles (10/2019 - 05/2002)
10. Kastelein, John J P: 24 articles (01/2021 - 10/2004)

Related Diseases

1. Atherosclerosis
2. Inflammation (Inflammations)
3. Cardiovascular Diseases (Cardiovascular Disease)
4. Type 2 Diabetes Mellitus (MODY)
5. Dyslipidemias (Dyslipidemia)

Related Drugs and Biologics

1. Apolipoprotein A-I (Apolipoprotein A1)
2. Cholesterol
3. HDL Lipoproteins
4. Apolipoproteins
5. HDL Cholesterol
6. Apolipoproteins B (ApoB)
7. Peptides (Polypeptides)
8. Proteins (Proteins, Gene)
9. Lipids
10. Triglycerides (Triacylglycerol)

Related Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Ligation
4. Punctures
5. Dietary Approaches To Stop Hypertension