Second Primary Neoplasms (Neoplasms, Second)

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Also Known As:
Neoplasms, Second; Second Primary Cancer; Neoplasms, Second Primary; Cancer, Second Primary; Metachronous Neoplasms; Metachronous Second Primary Neoplasms; Neoplasms, Therapy-Associated; Neoplasms, Treatment-Associated; Second Cancer; Second Primary Neoplasms, Metachronous; Therapy-Associated Cancer; Therapy-Related Neoplasms; Treatment-Associated Cancer; Treatment-Related Neoplasms; Cancer, Second; Cancer, Therapy-Associated; Cancer, Therapy-Related; Cancer, Treatment-Associated; Cancer, Treatment-Related; Cancers, Second; Cancers, Second Primary; Cancers, Therapy-Associated; Cancers, Therapy-Related; Cancers, Treatment-Associated; Cancers, Treatment-Related; Malignancies, Second; Malignancy, Second; Metachronous Neoplasm; Neoplasm, Metachronous; Neoplasm, Second; Neoplasm, Second Primary; Neoplasm, Therapy-Associated; Neoplasm, Therapy-Related; Neoplasm, Treatment-Associated; Neoplasm, Treatment-Related; Neoplasms, Therapy Associated; Neoplasms, Therapy Related; Neoplasms, Treatment Associated; Neoplasms, Treatment Related; Second Cancers; Second Malignancies; Second Neoplasms; Second Primary Cancers; Second Primary Neoplasm; Therapy Associated Cancer; Therapy Associated Neoplasms; Therapy Related Cancer; Therapy Related Neoplasms; Therapy-Associated Cancers; Therapy-Associated Neoplasm; Therapy-Related Cancers; Therapy-Related Neoplasm; Treatment Associated Cancer; Treatment Associated Neoplasms; Treatment Related Cancer; Treatment Related Neoplasms; Treatment-Associated Cancers; Treatment-Associated Neoplasm; Treatment-Related Cancers; Treatment-Related Neoplasm; Neoplasms, Metachronous; Neoplasms, Metachronous Second Primary; Neoplasms, Therapy-Related; Neoplasms, Treatment-Related; Second Malignancy; Second Neoplasm; Therapy-Associated Neoplasms; Therapy-Related Cancer; Treatment-Associated Neoplasms; Treatment-Related Cancer
Networked: 1067 relevant articles (47 outcomes, 102 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Hodgkin Disease (Hodgkin's Disease)
3. Head and Neck Neoplasms (Head and Neck Cancer)
4. Seminoma
5. Esophageal Neoplasms (Esophageal Cancer)


1. Schneider, Uwe: 12 articles (08/2015 - 11/2002)
2. Newhauser, Wayne D: 10 articles (05/2015 - 04/2009)
3. Paganetti, Harald: 8 articles (01/2016 - 07/2008)
4. Zhang, Rui: 7 articles (05/2015 - 12/2010)
5. Curtis, Rochelle E: 7 articles (01/2014 - 06/2005)
6. Robison, Leslie L: 6 articles (11/2015 - 06/2002)
7. Howell, Rebecca M: 5 articles (05/2015 - 11/2012)
8. Taddei, Phillip J: 5 articles (10/2014 - 04/2009)
9. Yock, Torunn I: 5 articles (06/2014 - 10/2012)
10. Tarbell, Nancy J: 5 articles (01/2014 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Second Primary Neoplasms:
1. RetinoidsIBA
2. lenalidomide (CC 5013)FDA Link
3. Protons (Proton)IBA
4. Etoposide (VP 16)FDA LinkGeneric
5. TamoxifenFDA LinkGeneric
6. Cyclophosphamide (Cytoxan)FDA LinkGeneric
7. Alkylating AgentsIBA
8. Doxorubicin (Adriamycin)FDA LinkGeneric
9. Melphalan (Alkeran)FDA LinkGeneric
10. Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Adjuvant Chemotherapy
4. Orchiectomy (Orchidectomy)
5. Chemoprevention