Talin

A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.

Also Known As:

Networked: 95 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Petrich, Brian G: 6 articles (07/2015 - 08/2007)
2.	Ginsberg, Mark H: 6 articles (07/2015 - 08/2007)
3.	Shattil, Sanford J: 3 articles (01/2012 - 08/2007)
4.	Lowy, Douglas R: 2 articles (12/2014 - 10/2011)
5.	Papageorge, Alex G: 2 articles (12/2014 - 10/2011)
6.	Qian, Xiaolan: 2 articles (12/2014 - 10/2011)
7.	Ye, Feng: 2 articles (04/2014 - 12/2007)
8.	Ross, Robert S: 2 articles (03/2014 - 12/2009)
9.	Desiniotis, Andreas: 2 articles (01/2014 - 01/2011)
10.	Kyprianou, Natasha: 2 articles (01/2014 - 01/2011)

Related Diseases

1.	Diabetic Neuropathies (Diabetic Neuropathy) 02/27/1997 - "We postulate that decreased perineurium talin in diabetic polyneuropathy may be related to the known alterations of the tight junctions of the perineurial cells, which have been proposed to be a contributory factor to impaired permeability barrier properties." 02/27/1997 - "On immunoblot, two bands at 235 and 190 kDa were found in the sural nerves with the antibody anti-talin, and both were reduced only in the patients with diabetic neuropathy. " 02/27/1997 - "Perineurium talin immunoreactivity decreases in diabetic neuropathy." 01/01/2006 - "Recent studies have shown significant reduction in the activity of nerve growth factor (NGF) and in the amount of talin cytoskeleton protein immunoreactivity in the perineurium in patients with diabetic neuropathy. "
2.	Ischemia 09/01/1998 - "After 60 minutes of intermittent ischemia followed by 2 hours of reperfusion, cell membrane bleb formation, calpain mu activation, and talin degradation were detected in groups 2 and 3 but not in group 1. The safest method of hepatic vascular clamping that produces a minimum or no ischemia-reperfusion injury is 60 minutes of 6 cycles of 10-minute vascular clamping interrupted by 5 minutes of reperfusion." 02/01/2001 - "At 10 mg/kg, prednisolone markedly suppressed IL-beta and TNF-alpha transcription and calpain mu activation and talin degradation, consistent with the improved 7-day survival after total hepatic ischemia (75% vs. 25% in control group, P = 0.039). "
3.	Reperfusion Injury 07/27/2015 - "These studies reveal the importance of talin-mediated activation of integrins for renal ischemia-reperfusion injury. " 09/01/1998 - "After 60 minutes of intermittent ischemia followed by 2 hours of reperfusion, cell membrane bleb formation, calpain mu activation, and talin degradation were detected in groups 2 and 3 but not in group 1. The safest method of hepatic vascular clamping that produces a minimum or no ischemia-reperfusion injury is 60 minutes of 6 cycles of 10-minute vascular clamping interrupted by 5 minutes of reperfusion." 07/21/2008 - "To investigate the effects of prednisolone on cell membrane bleb formation, calpain mu activation and talin degradation during hepatic ischemia-reperfusion injury in rats. "
4.	Epilepsy (Aura) 09/01/2010 - "To explore the possible role of talin 2 in epilepsy, we designed current study to quantitatively evaluate the changes in talin 2 levels in different epilepsy patients. " 02/01/2011 - "Talin 2 in the cerebrospinal fluid of patients with epilepsy." 09/01/2010 - "Talin 2 concentrations in cerebrospinal fluid in patients with epilepsy." 09/01/2010 - "We measured talin 2 levels in CSF and the serum of postencephalitic epilepsy (PEE) patients (subdivided into drug-refractory PEE-RPEE, and drug-effective PEE-EPEE groups) and acute encephalitis patients (subdivided into acute encephalitis with secondary seizures-AESS, and acute encephalitis without seizures-AE) by enzyme-linked immunosorbent assay. "
5.	Colonic Neoplasms (Colon Cancer) 01/01/2011 - "Proteomic analysis enabled us to establish PPP and the talin-pFAK as targets of RSV which suppress cancer cell proliferation and induce apoptosis in the colon cancer cell line HT-29. " 01/01/2011 - "Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach." 12/01/2007 - "In the present study, the synthetic ether lipid analog ET-18-OMe was shown to promote invasion of HCT-8/S11 colon cancer cells into collagen type I through the concomitant activation of src by phosphorylation at Tyr416 (5-30 min) in alpha1-integrin immunoprecipitates containing the integrin binding proteins talin and paxillin, as well as the phoshorylated and activated forms of focal adhesion kinase (FAK) at Tyr397 (a FAK kinase activation signal), Tyr576 and Tyr861. "

Related Drugs and Biologics

1.	Calpain
2.	Nerve Growth Factor (NGF)
3.	Prednisolone (Predate)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Dihydrotachysterol (AT 10)
6.	Vinculin
7.	Proteins (Proteins, Gene)
8.	Actinin
9.	Paxillin
10.	Integrins

Related Therapies and Procedures

1.	Traction
2.	Ovariectomy (Oophorectomy)
3.	Lasers (Laser)