Talin

A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.

Also Known As:

Networked: 156 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Petrich, Brian G: 7 articles (01/2019 - 08/2007)
2.	Ginsberg, Mark H: 6 articles (07/2015 - 08/2007)
3.	Hytönen, Vesa P: 5 articles (11/2021 - 10/2016)
4.	Huang, Cai: 4 articles (01/2020 - 05/2009)
5.	Goult, Benjamin T: 3 articles (11/2021 - 01/2016)
6.	Li, Xiang: 3 articles (01/2020 - 01/2011)
7.	Maes, Michael: 3 articles (01/2020 - 08/2019)
8.	Critchley, David R: 3 articles (01/2016 - 12/2007)
9.	Shattil, Sanford J: 3 articles (01/2012 - 08/2007)
10.	Strömblad, Staffan: 2 articles (01/2022 - 11/2012)

Related Diseases

1.	Diabetic Neuropathies (Diabetic Neuropathy) 02/27/1997 - "We postulate that decreased perineurium talin in diabetic polyneuropathy may be related to the known alterations of the tight junctions of the perineurial cells, which have been proposed to be a contributory factor to impaired permeability barrier properties." 02/27/1997 - "On immunoblot, two bands at 235 and 190 kDa were found in the sural nerves with the antibody anti-talin, and both were reduced only in the patients with diabetic neuropathy. " 02/27/1997 - "Perineurium talin immunoreactivity decreases in diabetic neuropathy." 01/01/2006 - "Recent studies have shown significant reduction in the activity of nerve growth factor (NGF) and in the amount of talin cytoskeleton protein immunoreactivity in the perineurium in patients with diabetic neuropathy. "
2.	Ischemia 09/01/1998 - "After 60 minutes of intermittent ischemia followed by 2 hours of reperfusion, cell membrane bleb formation, calpain mu activation, and talin degradation were detected in groups 2 and 3 but not in group 1. The safest method of hepatic vascular clamping that produces a minimum or no ischemia-reperfusion injury is 60 minutes of 6 cycles of 10-minute vascular clamping interrupted by 5 minutes of reperfusion." 02/01/2001 - "At 10 mg/kg, prednisolone markedly suppressed IL-beta and TNF-alpha transcription and calpain mu activation and talin degradation, consistent with the improved 7-day survival after total hepatic ischemia (75% vs. 25% in control group, P = 0.039). "
3.	Neoplasms (Cancer) 11/01/2021 - "Cancer associated talin point mutations disorganise cell adhesion and migration." 01/01/2018 - "Talin is a substrate for SUMOylation in migrating cancer cells." 10/11/2011 - "We conclude that the LD-like motif, which binds talin and FAK, is required for the full tumor suppressor activity of DLC1 and contributes to the association of DLC1 with focal adhesions." 01/01/2011 - "At the molecular level, talin is functionally associated with enhanced survival and proliferation pathways and confers anoikis resistance and metastatic spread of primary tumor cells via activation of the Akt survival pathway. " 01/01/2020 - "Talin: A Potential Drug Target for Cancer Therapy."
4.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "To better understand the mechanism underlying the function of talin in NSCLC invasion and metastasis, a few newly designed tension probe based on Förster resonance energy transfer was used for real-time observation of tension changes in A549 cells. " 01/01/2019 - "microRNA-96-5p induces the epithelial-mesenchymal transition to promote the metastasis of hepatocellular carcinoma by post-transcriptionally downregulating Talin 1." 06/09/2014 - "Thus, our findings provide a novel understanding of how intracellular pH is regulated and a molecular mechanism by which talin enhances tumor cell invasion and metastasis." 06/09/2014 - "Furthermore, talin is required for mammary tumor cell motility, intravasation, and spontaneous lung metastasis in vivo. " 06/09/2014 - "Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis."
5.	Breast Neoplasms (Breast Cancer) 06/09/2014 - "Here, we demonstrate that talin is required for invadopodial matrix degradation and three-dimensional extracellular matrix invasion in metastatic breast cancer cells. " 01/01/2018 - "In this study, we demonstrate that talin, a key component of FAs, can be post-translationally modified by SUMOylation in MDA-MB-231 breast cancer cells and U2OS osteosarcoma cells. " 01/01/2023 - "Our results suggest CdGAP as a candidate therapeutic target for HER2+ metastatic breast cancer by inhibiting TGF-β and integrin/talin signaling pathways." 01/01/2023 - "CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis." 04/15/2013 - "From ranking chemosensitivity of 328 short hairpin RNA (shRNA) MDA-MB-231 cell lines (targeting 133 genes with known somatic mutations in breast cancer), we focused on the top two genes, kinesin family member 14 (KIF14) and talin 1 (TLN1). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Calpain
3.	Nerve Growth Factor (NGF)
4.	Prednisolone (Predate)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Dihydrotachysterol (AT 10)
7.	Vinculin
8.	Integrins
9.	Paxillin
10.	Focal Adhesion Protein-Tyrosine Kinases

Related Therapies and Procedures

1.	Therapeutics
2.	Traction
3.	Ovariectomy (Oophorectomy)
4.	Lasers (Laser)