Aflatoxin M1 (Aflatoxin M)

A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).

Also Known As:

Networked: 29 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Aregu, Mekonen Birhane: 1 article (02/2022)
2.	Belachew, Tefera: 1 article (02/2022)
3.	Gebremeskel Kanno, Girum: 1 article (02/2022)
4.	Hussen Kabthymer, Robel: 1 article (02/2022)
5.	Paixão, Susana: 1 article (02/2022)
6.	Adesogan, Adegbola: 1 article (01/2022)
7.	Havelaar, Arie: 1 article (01/2022)
8.	Saha Turna, Nikita: 1 article (01/2022)
9.	Wu, Felicia: 1 article (01/2022)
10.	Akash, Muhammad Sajid Hamid: 1 article (11/2021)

Related Diseases

1.	Liver Neoplasms (Liver Cancer) 01/01/2022 - "Aflatoxin M1 in milk does not contribute substantially to global liver cancer incidence." 05/01/2009 - "Prevalence of aflatoxin M1 in milk and its potential liver cancer risk in Taiwan." 07/01/1993 - "617 children in high and low liver cancer incidence areas of Guangxi were observed for a study on the relationship between the dietary Aflatoxin B1 (AFB1) levels and Aflatoxin M1 (AFM1) excretion amounts in urine. " 07/01/2013 - "pylori prevalence with HBsAg positivity and urinary aflatoxin M1 in men in relation to liver cancer mortality. "
2.	Hepatocellular Carcinoma (Hepatoma) 03/01/1990 - "A new method for the quantitation of aflatoxin M1 in urine by high performance liquid chromatography and its application to the etiologic study of hepatoma." 02/01/2021 - "Aflatoxin M1 in raw cow milk and associated hepatocellular carcinoma risk among dairy farming households in Malawi."
3.	Hepatoblastoma 10/28/2018 - "Evaluation of Aflatoxin M1 Effects on the Metabolomic and Cytokinomic Profiling of a Hepatoblastoma Cell Line." 10/28/2018 - "Considering that hepatoblastoma develops in infants and children and aflatoxin M1 (AFM1), the aflatoxin B1 (AFB1) hydroxylated metabolite, can be present in mothers' milk and in marketed milk products, in this study we decided to test the effects of AFM1 on a hepatoblastoma cell line (HepG2). "
4.	Body Weight (Weight, Body) 01/01/2021 - "The in vivo kinetics of aflatoxin B1 (AFB1) and its carry-over as aflatoxin M1 (AFM1) in milk as well as the toxin loads in the tissue of dairy cows were assessed through a repetitive feeding trial of an AFB1-contaminated diet of 4 μg kg-1 body weight (b.w.) for 13 days. "
5.	Neoplasms (Cancer) 05/01/2023 - "Prevalence and concentration of Aflatoxin M1 in human breast milk in sub-Saharan Africa: a systematic review and meta-analysis, and cancer risk assessment." 01/01/2022 - "Aflatoxin M1 exposure in a fermented millet-based milk beverage 'brukina' and its cancer risk characterization in Greater Accra, Ghana." 01/01/2022 - "Exposure assessment and cancer risk characterization of aflatoxin M1 (AFM1) through ingestion of raw cow milk in southern Ghana." 01/01/1985 - "Cancer risks posed by aflatoxin M1." 01/01/2020 - "Aflatoxin M1 (AFM1), the 4-hydroxylated metabolite of AFB1, is the main AFB1-related compound present in milk, and it is categorized by the International Agency for Research on Cancer (IARC) as a "group 1 human carcinogen". "

Related Drugs and Biologics

1.	Aflatoxin B1 (Aflatoxin B)
2.	Aflatoxins
3.	Fatty Acids (Saturated Fatty Acids)
4.	Carcinogens
5.	hydrated sodium calcium aluminosilicate
6.	beta-Naphthoflavone
7.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
8.	Zearalenone
9.	Serum Albumin
10.	Mycotoxins