HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Trimetrexate (JB11)

A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Also Known As:
JB11; CI-898; JB-11; NSC-249008; NSC-328564; Trimetrexate Hydrate; Trimetrexate Monohydrate, Monoacetate; CI 898; CI898; Hydrate, Trimetrexate; JB 11; Monohydrate, Monoacetate Trimetrexate; NSC 249008; NSC 328564; NSC249008; NSC328564; 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-
Networked: 180 relevant articles (14 outcomes, 67 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Hammershaimb, L: 3 articles (01/2002 - 01/2002)
2. Blessing, John A: 2 articles (05/2002 - 01/2002)
3. Blanke, C D: 2 articles (01/2002 - 01/2002)
4. Lochs, H: 2 articles (01/2002 - 05/2000)
5. Punt, C J A: 2 articles (01/2002 - 01/2002)
6. Zhang, J: 2 articles (01/2002 - 01/2002)
7. Arevalo Bazalar, Maria: 1 article (12/2020)
8. Coiera, Enrico: 1 article (12/2020)
9. Laranjo, Liliana: 1 article (12/2020)
10. Quiroz, Juan C: 1 article (12/2020)

Related Diseases

1. Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia)
2. Acquired Immunodeficiency Syndrome (AIDS)
3. Neoplasms (Cancer)
4. Colorectal Neoplasms (Colorectal Cancer)
5. Leukemia

Related Drugs and Biologics

1. Leucovorin (Folinic Acid)
2. Folic Acid Antagonists
3. Trimetrexate (JB11)
4. didemnins
5. flavone acetic acid
6. brequinar
7. Quinazolines
8. Methotrexate (Mexate)
9. Dapsone
10. Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Transplantation
4. Injections